Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0007112 (
prostatic adenocarcinoma
)
2,574
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The proline-specific peptidases, aminopeptidase P (EC 3.4.11.9) and
dipeptidyl peptidase IV
(
EC 3.4.14.5
), were measured in human tissue homogenates and physiological fluids. All tissues examined contained measurable aminopeptidase P and
dipeptidyl peptidase IV
activities. High specific activities for both enzymes under study were found in benign prostatic hypertrophy. Normal prostate and
prostatic adenocarcinoma
had a much lower activity. This difference, however, is not reflected in the serum values of the patients. The most striking finding is the extremely high activity of
dipeptidyl peptidase IV
in prostatosomes, prostate-derived organelles, which occur freely in human seminal plasma, and which are important for enhancement of sperm forward motility.
...
PMID:Distribution of proline-specific aminopeptidases in human tissues and body fluids. 138 Aug 41
