Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007112 (prostatic adenocarcinoma)
 2,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients are presented with malignant tumors involving both bone and adjacent soft tissue. In each of these neoplasms (two representing adenocarcinoma of the prostate, and one each of squamous cell carcinoma of lung and chondrosarcoma), the lesions were detected by accumulation of Tc-99m MDP. Involvement of both bone and soft tissue was confirmed by CT examination or surgery. It is probable that the lesions originated in bone and then extended to soft tissue.
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PMID:Technetium-99m MDP demonstration of neoplastic lesions involving bone and adjacent soft tissue. 376 51

A patient with adenocarcinoma of the prostate presented with right upper quadrant abdominal pain and weight loss. Liver biopsy revealed hepatic metastases from prostate carcinoma. A bone scan demonstrated marked uptake of Tc-99m MDP within the hepatic metastases.
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PMID:Accumulation of a bone imaging agent in liver metastases from prostate carcinoma. 622 62

Brain metastasis in prostate cancer is rare and not expected at initial presentation especially when the patient is asymptomatic for the same. A 45-year-old male patient undergoing initial evaluation for newly diagnosed prostatic adenocarcinoma was referred to our department for 99mTc-MDP bone scintigraphy. As part of the study protocol, he also underwent Glu-NH-CO-NH-Lys-(Ahx)-[Ga-68(HBED-CC)] (68Ga-PSMA) PET/CT, which revealed tracer accumulation in brain lesions, apart from localization in the primary, lymph node, and bone metastases. A subsequent MR evaluation confirmed brain metastases.
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PMID:Detection of brain metastasis with 68Ga-labeled PSMA ligand PET/CT: a novel radiotracer for imaging of prostate carcinoma. 2567 61

A 76-year-old man with previously treated prostatic adenocarcinoma (Gleason 8) was referred for a Ga-prostate-specific membrane antigen PET/CT scan due to a rising serum PSA level. An intensely PSMA-avid focus was demonstrated in the left proximal tibia with no evidence of local recurrence or metastatic disease elsewhere. This was diagnosed and managed as enthesopathy. A Tc-MDP bone scan with SPECT/CT performed 9 months later confirmed an intensely osteoblastic mixed lytic/sclerotic metastasis at the left proximal tibia.
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PMID:Solitary 68Ga-PSMA-Avid Proximal Tibial Prostatic Adenocarcinoma Metastasis Mimicking Enthesopathy. 3315 56