Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007112 (prostatic adenocarcinoma)
 2,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ductal adenocarcinoma of the prostate is a variant of prostatic carcinoma that appears to originate in the ducts of the prostate. Carcinosarcoma of the prostate is an uncommon and aggressive tumour composed of an intimate admixture of adenocarcinoma and sarcoma. In this report we describe the clinicopathological and immunohistochemical characteristics of a case of prostatic carcinosarcoma that appeared in a 66-year-old man who had had a ductal adenocarcinoma of the prostate diagnosed 3 years previously. The patient died of the disease 3 months after the carcinosarcoma was diagnosed. This case may represent further evidence of the dedifferentiation theory in the origin of carcinosarcoma. The case also illustrates that this dedifferentiation may occur from any type of prostatic carcinoma.
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PMID:Prostatic carcinosarcoma: a case originating in a previous ductal adenocarcinoma of the prostate. 1098 20

Carcinosarcoma of the bladder is a rare neoplasm composed of a mixture of malignant epithelial and mesenchymal components. The presentation and clinical course of an infiltrating carcinosarcoma located in a bladder diverticulum coexisting with prostatic adenocarcinoma in a 69-year-old man are described. We believe this to be the fifth report of true carcinosarcoma appearing in a bladder diverticulum.
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PMID:Carcinosarcoma in a bladder diverticulum. A case report and literature review. 1105 38

Carcinosarcoma of the prostate is an extremely rare tumor. In the case of rapid tumor progression, especially after radiation therapy to the pelvis or after hormone deprivation therapy because of prostate cancer, this tumor entity should be considered, and immediate histological confirmation is required. The only curative therapy is immediate radical surgical excision. We report about the first case of a carcinosarcoma after salvage radiation therapy for local recurrence of adenocarcinoma of the prostate years after radical prostatectomy.
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PMID:[Appearance of carcinosarcoma after radiotherapy for local recurrence after radical prostatectomy. Case report and review of the literature]. 2023 7

Carcinosarcoma of the prostate is an uncommon malignancy with poor long-term prognosis. The cancer is typically discovered at an advanced stage, and with less than 100 reported cases, there is limited literature concerning treatment options. Our patient presented with a history of benign prostatic hypertrophy, erectile dysfunction, and nocturia. Biopsy of his prostate indicated that the patient had prostatic adenocarcinoma, but histopathology after prostatectomy revealed carcinosarcoma. It has been over six years since this patient's diagnosis of carcinosarcoma. Over this span of time, he has received a radical prostatectomy, radiotherapy, and androgen ablative therapy. The patient also developed multiple lung metastases that have been treated with video-assisted thoracic surgery and stereotactic body radiosurgery. Overall, he has remained unimpaired and in good condition despite his aggressive form of cancer.
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PMID:Prostatic carcinosarcoma with lung metastases. 2429 28