Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007097 (carcinoma)
 152,788 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Oxidized spermine, an iminoaldehyde, inhibited the energy metabolism of human sperm cells with striking specifity compared with other mammalian cell types. Low concentrations of oxidized spermine virtually abolished the conversion of glucose to CO2 and lactate in human sperm, whereas in Ehrlich ascites-carcinoma cells, in human peripheral lymphocytes, and in human vaginal minces, the iminoaldehyde caused little, if any, inhibition of glucose degradation. Other aliphatic aldehydes with long carbon chain, also inhibitory to human sperm cells, did not show cell specifity, depressing equally in all cell types. Heparin prevented but did not reverse the metabolic inhibition caused by oxidized spermine, but did not even prevent inhibitory action of other aliphatic aldehydes. Though largely unclear, the mechanism of action of this inhibitory phenomenon may involve a compound-cell interaction, since cell-free extracts did not produce the inhibition. That the inhibition caused by oxidized spermine differs from an unspecified detergent-like effect was supported by the ability of Triton-X to depress glucose degradation in all cell types, not just in human sperm cells. Oxidized spermine also inhibited conversion of radioactive pyruvate to CO2 in human sperm cells.
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PMID:Specific inhibition of spermatozoal energy metabolism by oxidized spermine. 56 86

N'-Methyl-N'-beta-chloroethylhydrazones are potent inducers of aerobic glycolysis of Ehrlich ascites carcinoma (E.A.) cells without influencing directly the respiration which is reduced only after glycolysis is at its maximum. This induction of glycolysis is not influenced by simultaneous blocking of respiration by potassium cyanide. A primary attack on the cell membrane leading to an increased glucose influx is discussed because of the in vitro inhibition of these beta-chloroethylhydrazones of glyceraldehyde-3-phosphate oxidoreductase.
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PMID:[Effect of N'-methyl-N'-beta-chlorethylbenzaldehyde hydrazone on aerobic glycolysis in Ehrlich ascites cells]. 58 Jan 90

We studied the ability of dietary glucose to cause an abrupt inhibition of free fatty acid (FFA) mobilization in mice bearing advanced Ehrlich ascites carcinoma. FFA irreversible disposal rates were estimated after i.v. injection of tracer [1-14C]palmitate complexed to mouse serum albumin. Four groups of mice were studied: 16-hr-fasted mice versus 16-hr-fasted mice refed a 58% glucose, fat-free test meal for 10 min; and control versus tumorous mice. Plasma FFA fell significantly [from 0.97 +/- 0.06 (S.E.) to 0.37 +/- 0.02 muEq/ml (n = 30 and 134, respectively)] following the ingestion of the small test meal. The lowered plasma FFA pool size remained approximately constant between t = 15 and 45 min after the mice began to eat. Tracer studies in the fasted-refed mice, carried out during that interval, showed that the plasma FFA irreversible disposal rate was reduced by 50% in both control and tumor-bearing mice. Although cancerous mice tended to have elevated plasma FFA levels in the early morning, these animals appear to have normal control mechanisms for inhibiting FFA mobilization following ingestion of carbohydrate.
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PMID:Regulation of plasma-free fatty acid mobilization by dietary glucose in Ehrlich ascites tumor-bearing mice. 66 34

The stationary phase of cell growth in suspension culture was analyzed with regard to nutritional depletion using FM3A cells originally derived from a spontaneous mammary carcinoma in a C3H mouse. When cells reached the stationary phase at the cell density of 5 X 10(5) cells/ml, cells began to lose the ability to form colonies and viability as determined by the dye exclusion test. When the amount of amino acids and vitamins in the medium decreased, cells reached the stationary phase at a low terminal density. Cells in the spent medium supplemented with amino acids, vitamins, glucose, and serum grew with the same growth rate as in the fresh medium. It is concluded that depletion of nutrients, especially amino acids and glucose, is the reason for the establishment of the stationary phase.
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PMID:Nutritional depletion of the established stationary phase during growth of mouse mammary carcinoma cells in suspension culture. 66 39

Oxidation of N-1 and N-2 alkylbenzotriazoles with m-chloroperbenzoic acid afforded 1-alkylbenzotriazole 3-oxides and 2-alkylbenzotriazole-4,4-diones, respectively. The quinonic compounds inhibited the "in vitro" growth of both HeLa and KB cells, the synthesis of macromolecules (DNA, RNA, and proteins), and the uptake of glucose by Ehrlich carcinoma ascites cells. A possible mode of action is suggested.
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PMID:Cytostatic quinones. 3. Synthesis of benzotriazolequinones by a new oxidation with m-chloroperbenzoic acid. Biochemical studies. 67 55

A case of lactic acidosis associated with the administration of hypertonic glucose to a patient with a bulky undifferentiated carcinoma is presented. Characteristic alterations in amino acid concentrations were observed during the period of lactic acidosis. Resolution of the metabolic abnormalities were seen with discontinuation of glucose infusion. Short-term glucose infusion in a 90 minute iv glucose tolerance test resulted in an increase in serum lactate and appropriate changes in serine, ornithine, taurine, alanine, and arginine despite normal hormonal responsiveness.
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PMID:Iatrogenic lactic acidosis: association with hypertonic glucose administration in a patient with cancer. 67 65

1,4-Dithiaanthraquinone-2,3-dicarbonitrile (DTA) has been found to exert a considerable cytostatic effect especially on some of the investigated types of eukaryotic cells, concretely on the HeLa cells, moulds, yeasts, protozoa and algae. In cells of the Ehrlich ascites carcinoma (EAC) DTA after a short exposition causes a parallel inhibition of incorporation of 14C-adenine and 14C-valine, in proportion to its rising concentration. The inhibition of biosynthetic processes thus made manifest, is probably a consequence of the primary DTA intervention into the energy metabolism of EAC cells, particularly in glycolysis. The effect of DTA in concentrations capable of bringing about full inhibition of glucose consumption or lactate formation in EAC cells also results in a loss of their transplantability. On the other hand, DTA also exerts a cancerostatic effect on the Ehrlich ascites carcinoma in mice.
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PMID:Cytotoxic and cancerostatic effect of 1,4-dithiaanthraquinone-2,3-dicarbonitrile. 74 57

The serum concentrations of alphaaminonitrogen (AAN), lysine, valine and leucines were determined before and within the period of 24 hr after the administration of Trophysan (10% solution of glucose containing a mixture of aminoacids) in 100 patients with cancer (17 with gastrointestinal carcinoma, 34 with uterus carcinoma, stages I to III; 8 with breast carcinoma, stages II and III; 15 with bronchogenic carcinoma, 10 with various localizations and 15 with metastatic cancer) and in 22 patients with benign tumors. A significant decrease in the serum content of AAN, valine and lysine was noted in patients with cancer (stages I to III) at 24 hours after the administration of Trophysan. This effect was absent for the patients with benign tumors. The enhanced uptake of aminoacids found in patients with cancer is probable the result of the negative nitrogen balance associated with the malignant state.
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PMID:Differences in uptake of aminoacids by patients with various forms of cancer. 74 62

Growth of Ehrlich ascites carcinoma induces hyperlipemia in mice. In the present study using male Swiss-Webster mice, we examined whether the usual elevations of plasma triglyceride levels in cancerous mice would occur in the absence of dietary fat. Hypertiglyceridemia developed at a similar rate and to a comparable degree in tumerous mice eating a fat-free (58% glucose) diet and in those fed Purina chow. Maximal hyperlipidemia was observed on day 6 or day 8 in tumorous mice fed either diet. To determine whether the endogenous cancer-induced hyperlipidemia was due to hypersecretion of triglycerides by the liver, triglyceride secretion rates were studied 0, 2, 4, 6, 8, 10, and 12 days after tumor inoculation using Triton WR-1339. The secretory rates did not increase prior to or during the development of hypertriglyceridemia in tumorous mice and were not significantly different from those of control mice. On days 10 and 12, triglyceride secretion actually decreased in tumorous mice. Other possible causes for hypertriglyceridemia are discussed in light of the present findings of undetectable differences in triglyceride secretion rates accompanying growth of Ehrlich ascites carcinoma in mice.
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PMID:The role of dietary fat and hepatic triglyceride secretion in cancer-induced hypertriglyceridemia. 75 Aug 29

Catalytic properties and isoenzyme composition of hexokinase were studied in extracts of normal thyroid, thyroid benign adenoma and thyroid carcinoma tissues from 23 patients. It was shown that the "cancer" hexokinase was several times more active and had lower Km (glucose) as compared with the enzyme from normal thyroid and benign tumor. Gel electrophoretic study revealed five hexokinase isoenzymes in both normal thyroid and its benign tumor. The hexokinase isoenzyme pattern in thyroid carcinoma was characterized by the "deletion" or distinctly decreased ratio of the "slowest" component. Studies on catalytic properties and isoenzyme composition of hexokinase are important as an additional test for the differentiation between benign and malignant tumors.
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PMID:[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]. 75 96


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