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Query: UMLS:C0007097 (carcinoma)
 152,788 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From 1960 through 1973, 415 patients with carcinoma of the esophagus were treated with radiation therapy. Three hundred and thirty-two patients had planned preoperative irradiation to a dose of 4500 rads in 18 fractions, and 101 of these had subsequent resections with either colon or stomach replacement. The operative mortality in this group was 18% and the 2- and 5-year survivals were 22.8 and 13.6%, respectively. The dose of 4500 rads in 18 fractions produced tumor sterilization in 3% and reduction to in situ carcinoma in 10% of these 101 patients. The survival was considerably improved in this small group of patients. Those patients not amenable to exploration had a 3% 5-year and a 5.6% 2-year survival was 12.1%. The overall survival was 9% at 2 years and 6% at 5 years. The results in this series are compared with the most recent reports in the literature.
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PMID:Preoperative radiation therapy for carcinoma of the esophagus. 82 Apr 26

Two cases of varicoid carcinoma of the esophagus are presented and differentiation from the similar findings in esophageal varices is emphasized. Radiographically, distinction must be made on the basis of changeability of the configuration of the wall with positional change and alterations in the respiratory pattern, a characteristic feature of varices. Endoscopically, no change is seen in varicoid carcinoma with the respiratory cycle. The latter may have a pallid white appearance in contrast to the bluish color of varices. An area of ulceration would strongly suggest carcinoma, indicating biopsy.
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PMID:Varicoid carcinoma of the esophagus. 84 Oct 34

Unusual metastases occur in a significant percentage of patients with malignant disease. In large measure, they represent a preterminal event. This is not always the case, however. In patients who have metastases to the skin, the event is generally preterminal particularly when the primary is the lung. In that instance the time between appearance of the metastasis and death is between 1.5 and 2.6 mo. Metastases to the skin occurring in patients with carcinoma of the cervix also represents a preterminal event with a time from diagnosis to death of 3 mo. In patients with carcinoma of the esophagus, the time from diagnosis to death is 4.3 mo, on the average. On the other hand, metastases to the skin from primary malignant tumors involving the colon, bladder, kidney, and ovary do not represent preterminal events. The time form diagnosis to death varies from 7.3 mo in carcinoma of the ovary to 12.7 mo in carcinomas of the kidney. Therefore, it is important when a patient presents with metastases to the skin to establish the primary source, the extent of the metastatic lesions and devise treatment programs that are appropriate to the pattern of the metastasis and the primary diagnosis...
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PMID:Unusual sites of metastases. 84 51

A prospective study of carcinoma of the stomach and oesophagus has been carried out for 2 1/2 years. Seventy-three cases of carcinoma of the stomach, and 16 cases of carcinoma of the oesophagus have been documented. For carcinoma of the stomach, operability rate was 72-6% and resectability rate was 41-9%; overall survival was poor, 20-9% at 12 months. For those who underwent resection, survival at 12 months was 45-5%. No cases of early gastric cancer are among those studied. For carcinoma of the oesophagus, four patients had a resection, and only one has survived for more than 12 months. In the clinical sphere there is a need for early endoscopic as well as radiological investigation of dyspeptic symptoms. In the research field there is a need for studies of chemotherapy in combination with surgery in the initial treatment of gastric carcinoma.
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PMID:A prospective study of gastric and oesophageal carcinoma. 89 4

This report concerns our experience in the treatment of 125 patients with carcinoma of the esophagus during 17 years (excluding the cardiac region of the stomach). In our material predisponsing factors had no effect upon the age of the patients. The symptomatology is described, the causes of postoperative complications and mortality are discussed. The principal indications are mentioned and technical considerations are summariced. Radical tumor resection resulted in a 2 year survival rate of 23 percent. Palliativ resections in cases of advanced carcinoma are refused because of the high mortality rate and the small expectation of life.
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PMID:[Report of 125 esophageal carcinomas (author's transl)]. 108 51

A case of adenoid cystic carcinoma of the oesophagus occurring in a patient who had previously been treated for craniopharyngioma is presented. This is the thirteenth reported case of adenoid cystic carcinoma of the oesophagus and the first in association with craniopharyngioma. The previously described cases of oesophageal adenoid cystic carcinoma are critically reviewed, and it is suggested that this tumour is in general highly malignant and may not be so rare as is generally thought.
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PMID:Adenoid cystic carcinoma of the oesophagus. 117 34

154 patients in 16,523 consecutive autopsies had carcinoma of the oesophagus or gastric cardia. Thirty-three of these patients had had an oesophagogastric resection, 33 radiation therapy and 88 no effective therapy. In 47% of the cases given effective treatment (66 cases) no tumour tissue was detected at the autopsy. 20% of patients with no effective therapy had a localised tumour. Most of the localised tumours were in the lower third of the thoracic oesophagus. When an oesophageal or cardiac carcinoma without effective therapy was no longer localised, it was more than twice as likely that the tumour had already spread in combined ways. The localised stage and the local invasion of the tumour were to some extent dependent on the length of the tumour, but distant metastasizing was not dependent on it. 84% of the cases had direct or indirect complications caused by the tumour. The patients with oesophageal carcinoma had died twice as often of tumour complications than of metastases, whereas cardiac carcinomas led to death from metastases considerably more often than from tumour complications. The series included three cases of aorto-oesophageal fistula.
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PMID:Carcinoma of the oesophagus and gastric cardia at autopsy in Finland. 121 49

Between January 1975 and December 1989, the Cardiothoracic Unit of the University College Hospital, Ibadan (U.C.H.) carried out 47 oesophageal replacement procedures using the stomach. The ages of the patients ranged from 3 to 75 years (mean = 53.2 +/- 19.3 years). There were 24 males and 23 females. The indications for oesophageal replacement were as follows: Carcinoma of the oesophagus--34 patients (73.9%), Corrosive stricture--9 patients (17.4%), peptic stricture--1 patient (2.2%), granulomatous oesophageal lesion--1 patient (2.2%), submucous cysts--1 patient (2.2%), oesophageal perforation--1 (2.2%). Twenty patients (58.8%) with oesophageal carcinoma died between 9 and 33 days after operation. The patients with oesophageal perforation, granulomatous lesion and submucous cysts died from sepsis 8, 13 and 6 days respectively after operation due to anastomotic leak. Three patients with corrosive stricture (24%) died 10, 13 and 15 days respectively after operation. All the other 21 (54.7%) patients survived with good results as judged by the absence of dysphagia. Eight of the fourteen surviving patients with carcinoma are lost to follow-up and are presumed dead. There were two intra-operative deaths (4.3%). The operative approaches used were: Transthoracic (21 patients; 9 deaths), Transhiatal oesophagectomy (14 patients; 9 deaths) and retrosternal route (12 patients; 8 deaths). In terms of morbidity, more complications were observed with the transhiatal oesophagectomy (Orringer's technique). It is concluded that whereas oesophagoplasty with the stomach offers good results in patients with benign strictures, the results with carcinoma of the oesophagus in our environment is poor.
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PMID:Oesophageal reconstruction using the stomach. 130 85

Thoracic CT scans were performed preoperatively in 19 patients with carcinoma of the esophagus and one patient with esophageal leiomyoma. CT findings were compared with surgical and pathological findings before and after operation. CT was shown to be inaccurate in the preoperative assessment of the involvement of esophageal carcinoma and of little value in judging potential resectability (69%). Its accuracy was low in staging the tumor, usually understaging (37.5% staging II) or overstaging tumor (45.4% staging III), without information about suitable treatment of esophageal cancer. With low accuracy in visualizing lymph nodes of the mediastinum and periesophagus (30%), it is not helpful in distinguishing benign from malignant tumor of the esophagus.
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PMID:[Preoperative CT scan for esophageal tumor]. 130 34

This paper reports a case with an undifferentiated carcinoma of the esophagus which primarily developed symptoms due to metastatic lesions. The case was a 59-year-old woman with a primary manifestation of an abdominal mass and with subsequent dysphagia. A protruding lesion with ulceration was found at the lower third of the thoracic esophagus by endoscopic examination and was histologically proved to be an undifferentiated carcinoma by biopsy. The abdominal mass was initially thought to be due to metastasis to an abdominal lymph node based on the diagnosis image finding at admission, but it was consequently found by autopsy to be a metastatic tumor in the liver. Therefore, undifferentiated carcinoma of the esophagus should be take into account for differential diagnosis of an abdominal mass.
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PMID:A case of an undifferentiated small cell carcinoma of the esophagus with a primary abdominal mass. 131 99


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