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Query: UMLS:C0007097 (carcinoma)
 152,788 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationships between cancer histotype and characters of the mammary glandular tree have been studied in 100 human breasts removed for clinical cancer by radical mastectomy. The group of invasive ductal carcinomas, including 78 cases, was subclassified in not otherwise specified (53 cases), with intraductal (19 cases), and with tubular component (6 cases). The other cancer histotypes were invasive lobular carcinoma (9 cases), medullary carcinoma (7 cases), mucinous carcinoma (4 cases), and papillary carcinoma (2 cases). The pattern of the mammary glandular tree was atrophic (67 cases) or adenosic, i.e., rich in mammary lobules (33 cases), but mammary lobules (normal, paranormal, atypical, or persistent in otherwise atrophic breasts) were present in 83% of the cases. A significant prevalence of not otherwise specified cancer (X2 = 10.20; p less than 0.01) was found in atrophic breasts (64%) and, even more, in breasts without lobules (76%). By contrast, intraductal component, tubular component, invasive lobular, and medullary cancers were, with two single exceptions, only in breasts with lobules, and this concentration was also significant (X2 = 7.26; p less than 0.01). It is concluded that breast cancer histotype is influenced by, or related to, the surrounding microenvironment, i.e., the pattern of the mammary glandular tree.
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PMID:Correlations between histologic type of clinical breast cancer and physiopathologic profile of the mammary glandular tree. 667 90

The authors reviewed the clinical and pathologic features of 35 cases of secondary ovarian neoplasms in which the clinical presentation was that of a primary ovarian tumor. The most common secondary neoplasms to mimic an ovarian tumor were colonic adenocarcinoma, breast carcinoma, lymphoma, carcinoid, and gastric adenocarcinoma. It was found that a classification based on gross appearance was useful in evaluating these neoplasms. Solid neoplasms with either a diffuse or nodular gross appearance had distinct histologies so that accurate diagnosis was possible. Cystic neoplasms, especially colon adenocarcinomas, were deceptive and frequently misclassified as primary ovarian adenocarcinoma. Since all of the metastatic colonic carcinomas had mucus-containing cells, the main differential diagnosis was between metastatic colonic carcinoma and primary mucinous carcinoma of the ovary. The absence of a mucus-cell predominant pattern and the lack of transition from benign-appearing epithelium to malignant epithelium are two useful criteria in making this important distinction. Other features may also prove helpful.
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PMID:Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. 669 4

The histological patterns of 120 adenomas and 365 carcinomas of the rectum were established cytologically in accordance with the WHO Histological Classification of Tumours on the basis of morphological, cellular and functional characteristics of neoplasm differentiation. It was found that cytological methods cannot be fully relied upon in the identification of the histological pattern of adenoma. Three degrees of adenoma cell atypia are distinguished: mild, moderate and severe. The latter is more characteristic of villous tumor. The following cytological classification of rectal cancer is suggested: 1. Adenocarcinoma: (a) well-differentiated, (b) moderately-differentiated. 2. Mucinous adenocarcinoma. 3. Signet-ring cell carcinoma. 4. Squamous cell carcinoma: (a) keratinizing, (b) non-keratinizing. 5. Undifferentiated cell carcinoma. 6. Carcinoma (histologically unidentifiable).
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PMID:[Standardization of the cytological conclusions in adenomas and cancer of the rectum]. 683 76

A clinico-pathological study of 48 malignant Brenner tumors (MBT) includes three new cases and 45 cases from the literature since 1945. Construction of a profile of this neoplasm was undertaken. The mean age of patients was 60 years, and most were postmenopausal with abdominal symptoms and a unilateral abdominopelvic mass. Only one case had bilateral tumors. The pattern of spread of this tumor is usually regional with only occasional distant metastases. Diffuse peritoneal seeding is not a characteristic feature of MBT. 56% of the patients with MBT died of their tumor, usually within 3 years of initial diagnosis. Mean survival in fatal cases was 1 year. Microscopically, foci of characteristic benign Brenner tumor may or may not be seen in individual examples of MBT. Admixture of adenocarcinoma (often mucinous carcinoma) and squamous carcinoma may also be seen. diagnostic problems can arise when a mixture of histologic patterns is present. In order to establish the diagnosis of malignant Brenner tumor a prominent histologic pattern of malignant urothelium is usually necessary.
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PMID:Malignant Brenner tumor of the ovary. Report of three cases. 721 26

Histological examinations were performed on the removed mammary glands of 79 patients with locally disseminated mammary gland carcinoma operated on after a course of polychemotherapy with 5-fluorouracyl, methatrexate, vincristin, cyclophosphane and hormonal treatment including ovariectomy in women of the reproductive age and in menopause up to 5 years followed by corticosteroid therapy. Signs of medicinal pathomorphosis were revealed in 70 patients. The patients were classified into 4 groups depending on the degree of pathomorphosis intensity. In most cases the latter corresponded to the intensity of the clinical effect. No association could be established between the degree of pathomorphosis and that of the tumour dissemination. Specific histological forms of cancer (mucinous carcinoma, lobular carcinoma) and highly differentiated forms (glandular carcinoma, scirr) are more resistant to the effect of antitumour drugs.
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PMID:[Drug pathomorphosis of breast cancer (proceedings)]. 740 28

From 1988 to 1993 we treated 1,310 cases of fine needle aspiration cytology of breast lesions. The results were positive for malignancy in 218, suspicious in 134, negative in 857, and inadequate specimen in 101. Histological examinations were performed in 461 cases; 243 malignancies and 218 benign lesions. The cytological diagnosis of these cases was positive in 211, suspicious in 91, negative in 142 and inadequate specimen in 17. The cytologic diagnosis of the cases of histological malignancy was positive in 198, suspicious in 24, negative in 17 and inadequate specimen in 4. Therefore we have 17 false negative cases. The histological diagnoses in these cases were scirrhous carcinoma (7), papillotubular carcinoma (6), invasive lobular carcinoma (2), mucinous carcinoma (1) and angiosarcoma (1). There were 13 cases of cytologically false positive cases; the histological diagnoses were fibroadenoma (4), mastopathy (4), papilloma (3), adenosis (1) and xanthogranuloma (1). For over six years, we have used a computer system incorporating both cytologic and histologic records. This system is very useful in quickly review the correlations of cytologic-histologic diagnoses. In addition to this system, a close relationship between clinical to pathological department is necessary in the quality control of diagnostic cytology.
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PMID:[Quality control of fine needle aspiration cytology of breast lesions]. 747 40

Pseudomyxoma peritonei (PMP) is a poorly understood condition characterized by mucinous ascites and mucinous implants diffusely involving the peritoneal surfaces. There is considerable debate regarding the definition, pathology, site of origin, and prognosis of PMP. We analyzed the clinicopathologic features of 109 cases of multifocal peritoneal mucinous tumors to develop a pathologic definition of cases characterized by the clinical condition PMP. Cases were separated into two diagnostic categories: disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis (PMCA). Cases classified as DPAM were characterized by peritoneal lesions composed of abundant extracellular mucin containing scant simple to focally proliferative mucinous epithelium with little cytologic atypia or mitotic activity, with or without an associated appendiceal mucinous adenoma. Cases classified as PMCA were characterized by peritoneal lesions composed of more abundant mucinous epithelium with the architectural and cytologic features of carcinoma, with or without an associated primary mucinous adenocarcinoma. Sixty-five of the 109 cases (59.6%) were classified as DPAM consistent with origin from an appendiceal mucinous adenoma. Thirty-seven of the 65 cases (56.9%) had a documented appendiceal mucinous adenoma. Thirty cases (27.5%) were classified as PMCA consistent with origin from an appendiceal or intestinal mucinous adenocarcinoma. Fourteen cases (12.8%) were classified as PMCA with features intermediate between DPAM and PMCA or with discordant features based on the finding of at least focal areas of carcinoma in the peritoneal lesions, whether or not the primary site demonstrated carcinoma. The cases with intermediate features were derived from well-differentiated appendiceal or intestinal mucinous adenocarcinomas and had peritoneal lesions displaying features of DPAM as well as focal areas of mucinous carcinoma. The cases with discordant features were derived from atypical appendiceal adenomas with little or no histologic evidence of a transition from adenoma to carcinoma and had peritoneal lesions uniformly composed of mucinous carcinoma. There was a statistically significant difference in survival between cases classified as DPAM, those classified as PMCA with intermediate or discordant features, and those classified as PMCA (p < 0.0001). The age-adjusted 5-year survival rates were 84% for patients with DPAM, 37.6% for patients with PMCA with intermediate or discordant features, and 6.7% for patients with PMCA. The term DPAM should be used to diagnose the histologically benign peritoneal lesions associated with ruptured appendiceal mucinous adenomas and those that are pathologically identical but lack a demonstrable appendiceal adenoma. Cases with the pathologic features of adenocarcinoma should be designated PMCA because they have recognizably different pathologic features and a significantly worse prognosis.
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PMID:Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei". 750 61

An 80-year-old nullipara had a 2.0-cm cystic tumor of the right labium majus. Histologic diagnosis was mucinous eccrine carcinoma. Seventy-five percent of these rare skin adnexal tumors arise on the face, eyelid, or scalp; but none has been reported on the vulva. Indolent localized growth is usual with regional nodal spread in 11% and distant metastases in 3%. A 67-year-old multipara had a 1.2-cm polypoidal nodule of the posterior fourchette. Histologically, a colonic type mucinous carcinoma was arising within a villous adenoma. Mucicarmine and CEA stains were positive. Extensive workup failed to reveal other primary cancers in either patient. Both patients are well 19 and 17 months after radical vulvectomies and node-negative groin dissections. These cases illustrate further the diversity in cell type and biologic behavior of vulvar adenocarcinomas.
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PMID:Mucinous adenocarcinomas of the vulva. 753 21

Endocrine cells (EC) were found in 19 out of 42 cases of the pancreas carcinoma (42.5%). Among them, 4 cases had a positive rate of EC more than 50%. The positive rate of EC in the well differentiated carcinomas (5/20) was lower than that of the poorly-differentiated ones (12/19) or mucinous carcinoma (2/2), and the positive rate in histologic grade I cases (5/18) was significantly lower than that of the grade III cases (7/8). The number of mast cells infiltrating in the matrix in EC positive cases was significantly higher than that of the negative ones. The positive rate of EC in the cases with metastasis (8/14) was higher than that of the non-metastasis cases (7/21). Immunocytochemical staining showed that GN (8), SS(4), HCG(5), CK(12), EMA(13) and CEA(9) were positive in 19 EC positive cases.
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PMID:[The biological significance of endocrine cells in pancreatic carcinoma]. 753 37

Immunolocalization of a variety of integrins using monoclonal antibodies against beta 3, beta 5, alpha 3 beta 1 and alpha 6, and polyclonal antibodies against vitronectin receptor (alpha v beta 3) and beta 1 were investigated on PLP-fixed paraffin sections of 19 cases of advanced gastric carcinomas. The beta 5 integrin, which pairs only with the alpha v subunit, was positive in seven cases (37%), and was associated closely with scirrhous invasion (P < 0.05). beta 5 was positive chiefly in the cytoplasm of carcinoma cells and infrequently in cell membranes. beta 3, which is another subunit pairing with alpha v, was positive in six cases (32%), and tended to be associated with scirrhous invasion (P < 0.01). beta 3 was also located chiefly in the cytoplasm. Five of the seven beta 5-positive cases showed coexpression of beta 3. Polyclonal antibodies to alpha v beta 3 also showed a significant difference among the amounts of stroma (P < 0.05). Anti-beta 1 antibodies showed clear positivity in many cases (89%). Of the beta 1 integrins, alpha 3 beta 1 was positive in a few cases (26%) without any preferential pattern, and laminin receptor subunit alpha 6 stained on cell membranes of neoplastic epithelia in many cases of carcinoma (89%) except for mucinous carcinoma These distinctive patterns of integrin positivity indicate a close association of beta 5 and beta 3 expression with scirrhous invasion in gastric carcinoma.
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PMID:Integrin distribution in gastric carcinoma: association of beta 3 and beta 5 integrins with tumor invasiveness. 755 Oct 9


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