Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007097 (carcinoma)
 152,788 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Study of 52 patients with ovarian endometriosis supports the point of view about the relative autonomy of ovarian endometriosis from the cyclic hormonal alterations in female organism. In the foci of endometriosis the signs of differentiation of the epithelium by both tubal and endocervical types are revealed. This enables one to admit the possibility of ovarian serous and mucinous carcinoma development from the foci of endometriosis. Marked dysplastic changes, up to the focal carcinoma, are revealed but there were no signs of invasion. In the genesis of endometrioid carcinoma the great importance is attributed to the step-like process: endometriosis----borderline endometrioid tumour----endometrioid cancer.
 ...
PMID:[Ovarian endometriosis]. 227 Sep 76

Carcinomas of the colon were induced in F344 rats with dimethylhydrazine (20 mg/kg for 12 weeks). The invasive edges of the lesions were examined with the electron microscope. As in human colorectal cancer, the invasive edges show neoplastic cells with abnormal differentiation of apical cytoplasmic rootlets and processes at the basal or invasive edge of the cell, 'apical reversal'. Mucous carcinoma cells release material into the interstitial connective tissue matrix. The features may contribute to the complex phenomenon of neoplastic invasion.
 ...
PMID:Neoplastic invasion in experimental carcinoma of the colon: abnormal differentiation and release of mucus. 235 Sep 17

Mucinous adenocarcinoma of the prostate gland is one of the least common morphologic variants of prostatic carcinoma. A lack of precision in the definition of these mucinous neoplasms has resulted in reports which have overstated the incidence of this lesion. Of approximately 1,600 carcinomas of the prostate gland seen at Memorial Hospital from 1963 to 1983, excluding cases with only needle biopsy material, six mucinous prostatic adenocarcinomas were identified. Mucinous prostatic carcinomas were diagnosed when at least 25% of the resected tumor contained lakes of extracellular mucin, and an extraprostatic tumor site was ruled out. In five of the six cases, a cribriform pattern predominated in the mucinous areas. All of the mucinous prostatic tumors had prostate-specific acid phosphatase (PSAP) and prostate-specific antigen (PSA) immunoreactivity. Our experience and our review of the literature indicate that these tumors do not respond well to hormonal therapy. Contrary to prevalent opinion, they have an aggressive biologic behavior and, like nonmucinous prostate carcinomas, have a propensity to develop bone metastases and increased serum acid phosphatase levels with advanced disease.
 ...
PMID:Mucinous adenocarcinoma of the prostate gland. 240 26

Serum CA125, CEA, AFP, LDH levels and LDH isoenzymes were analyzed in ovarian tumor patients, who were treated at Kyoto University Hospital. CA125 was positive in 10/16 (62.5%) cases of common epithelial carcinoma, especially 100% positive in serous carcinoma, but was negative in mucinous tumors. CA125 was also negative in patients with germ cell and sex cord stromal tumors. CEA was positive in 13/32 (40.6%) cases of epithelial carcinoma, most frequently elevated in patients with mucinous carcinoma, pseudomyxoma peritonei, and Krukenberg tumor. AFP was positive only in those with endodermal sinus tumors. LDH was elevated in 16/39 (41%) cases of epithelial carcinoma, but was not specific for histological types. In contrast, all 8 cases of dysgerminoma, 1 of immature teratoma and 2 of endodermal sinus tumor showed extremely elevated LDH levels. Moreover, the normal pattern or deviation to H subunit of LDH isoenzymes was seen in such cases of germ cell tumor, while deviation to M subunit was noted in epithelial and metastatic tumor patients. These data indicate that each parameter is useful as a tumor marker for the specific histological type of ovarian tumor; CA125 for non-mucinous epithelial carcinoma, CEA for mucinous tumor and Krukenberg tumor, AFP for yolk sac tumor, LDH and LDH isoenzymes for dysgerminoma and other solid germ cell tumors. In addition, preoperative diagnosis of histological types of ovarian tumors may be possible by combining these tumor markers.
 ...
PMID:[Analysis of serum CA125, CEA, AFP, LDH levels and LDH isoenzymes in patients with ovarian tumors--correlation between tumor markers and histological types of ovarian tumors]. 242 74

High-quality, high-resolution, proton-decoupled natural-abundance 13C NMR spectra have been obtained in vitro at 100.6 MHz from unprocessed human pathology specimens of tumors and adjacent nonneoplastic control tissues from lung, colon, and prostate. In these preliminary studies, specific molecular parameters were identified from the spectra that distinguished neoplastic from nonneoplastic tissue of a given organ in all sites studied. The NMR results were congruent with data derived from histochemical and biochemical examinations of the tissues and with previous studies using non-NMR methods. In particular, a comparison of the spectra of prostatic adenocarcinoma with that of adjacent hyperplastic tissue revealed the following differences: The tumors contained (1) larger amounts of triacylglycerols, (2) smaller amounts of citrate, and (3) acidic mucins. These transformation-associated deviations from the normally high amounts of citrate and low amounts of lipids in the prostate are consistent with an alteration in either the concentration or the activity of ATP-citrate lyase in the tumors. The 13C NMR spectra of colonic adenocarcinoma tissue showed that this tumor type contained (1) smaller signals from triacylglycerols, (2) larger signals from phospholipids and lactate, and (3) decreased lipid fatty acyl chain saturation, when compared to spectra from adjacent normal colon. Colloid carcinoma, another variant of colonic carcinoma, showed prominent 13C resonances from glycoproteins, which were absent from the spectra of normal colon, and from spectra from the more common pattern of colonic adenocarcinoma. Smaller 13C NMR signals from mucins and other proteins, and the presence of triacylglycerol signals distinguished poorly differentiated lung carcinoma and from nonmalignant lung tissue. These results indicate that natural-abundance 13C NMR spectroscopy may constitute a unique, nondestructive method, for the simultaneous measurement of a large number of tissue metabolites and structural components of significance to the study and diagnosis of a wide range of human tumors.
 ...
PMID:Differentiation of human tumors from nonmalignant tissue by natural-abundance 13C NMR spectroscopy. 245 80

Thickened gastric walls of diffusely low attenuation were observed on CT of three of eight patients with mucinous adenocarcinoma in a retrospective review of 141 cases of gastric carcinoma. On pathologic examination the low attenuation correlated with large amounts of mucin in the pathologic specimens. Mucinous adenocarcinoma with abundant mucin should be included in the differential diagnosis of thickened gastric walls of diffusely low attenuation.
 ...
PMID:Thickened gastric walls showing diffuse low attenuation on CT. 253 92

In its pure form, mucinous breast carcinoma (MC) has a much better prognosis than infiltrating ductal carcinoma (IDC). Mixed MC-IDC has the prognosis of IDC. We compared the fine-needle aspiration (FNA) cytology and histology of nine cases of pure MC with 13 cases of mixed MC-IDC. While typical of pure MC, abundant mucin (3+/3+) was noted in smears from three cases of mixed tumor and is thus necessary but not sufficient for a diagnosis of pure MC. Cellular pleomorphism has been said not to be a feature of MC; however, we found occasional large cells markedly different from the typical small uniform cells of MC in four pure and seven mixed tumors. Cytologic features indicative of a mixed tumor include one or more smears totally without mucin, scantly amounts of mucin, or necrosis. A combination of features indicative of pure mucinous carcinoma in FNA included abundant mucin on all smears, no pleomorphism, and no necrosis. Many cases will have smear patterns that are not typical of either profile and should probably be designated as carcinoma with a mucinous component.
 ...
PMID:Mucinous breast carcinoma and mixed mucinous-infiltrating ductal carcinoma: a comparative cytologic study. 255 Jan 88

Eleven new cases of colorectal carcinoma in children (0-15 years of age) are added to the 212 cases already described in the literature. Mucinous adenocarcinoma was the most frequent histological type. Acute abdominal obstruction was the most frequent presentation. A radiologic diagnosis of malignancy was made in only six of eleven cases. The interval between onset of clinical symptoms and diagnosis ranged from two days to one year. Duration of symptoms, pathologic findings, stage, and prognosis differed markedly as compared with adult colorectal carcinomas. In spite of its rarity, colorectal malignancies may occur in children.
 ...
PMID:Colorectal adenocarcinoma in childhood and adolescent. Report of 11 cases and review of the literature. 255 86

The main criteria for the morphological diagnosis of the "pure" and mixed mucinous carcinoma are established on the basis of studying 83 mucinous carcinomas of the mammary gland. The necessity to differentiate is pointed out between the "pure" from of this carcinoma and the mixed one as the former has a much more favourable prognosis as compared to the latter which, in its turn, has a more favourable prognosis than an infiltrative ductal carcinoma. Total 10-year-survival of patients with "pure" and mixed variants of the mucinous carcinoma is 90.46 +/- 7.27 and 58.29 +/- 11.1, respectively. The radical mammary gland resection is recommended in patients with a "pure" variant of mucinous carcinoma at 1 and 11 A stages of the disease.
 ...
PMID:[Mucinous carcinoma of the breast (clinico-morphological characteristics)]. 255 66

Secretory carcinoma and mucinous carcinoma were found to coexist in the breast of a 67-year-old post-menopausal woman, although the tumors were separated by a thin fibrous septum. Histochemically, intra- and extracellular secretory materials in both carcinomas were strongly positive for alcian blue, PAS and mucicarmine staining, but immunohistochemically negative for alpha-lactalbumin and CEA. Membrane-bound intracytoplasmic vacuoles showing emiocytosis were observed in both the secretory and mucinous carcinomas by electron microscopy. No differences were observed between the tumor cells of secretory carcinoma and those of mucinous carcinoma by histochemistry, immunohistochemistry and electron microscopy. However, there were definite statistically significant differences in the results of morphometry of tumor cell nuclei. Secretory carcinoma is considered to be an anaplastic variant type of mucinous carcinoma.
 ...
PMID:Secretory carcinoma coexistent with mucinous carcinoma in the breast. Report of a case. 255 85


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>