Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007097 (carcinoma)
 152,788 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activity of pyridoxal kinase (per 1 g of tissue or per 1 mg of protein) varied in the range from 7 to 39 un or from 0.079 to 0.4 un in human malignant neoplasm tissues (adenocarcinoma of various localization, squamatous cell carcinoma of lungs, skin melanoma). The direction of alterations in the pyridoxal kinase activity differed in various tumors studied as compared with the respective controls (unimpaired tissues used for growing malignant cells).
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PMID:[Pyridoxal kinase activity in human tumor tissues]. 20 94

1. Fifty-five microscopic cancer foci from 11 gastric resection preparations have been examined. Each focus than 5 mm was less in diameter. They occurred mostly in regions showing chronic atrophic gastritis, less frequently in the margin of peptic ulcer or in a polyp located in the antrum along the lesser curve. The lesions were discovered at routine histologic examination of stomachs operated upon for other primary diseases. 2. Histologically differentiated and undifferentiated types could be distinguished. They were: well differentiated adenocarcinoma, tubular adenocarcinoma, "intraluminal papillary proliferation of the glandular neck", "glandular neck displasia" mucocellular and muconodular carcinoma, and carcinoma in situ. In some cases, different histologic types within the same focus, or more foci of diverse structure in the same patient could be observed. 3. A malignant process developing from the glandular neck region or the surface epithelium could be demonstrated in each type of initial cancer.
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PMID:Special forms of initial gastric cancer. 20 71

The mammary gland cancer metastasizes most frequently into lymph nodes, the liver, bones, lungs and adrenal glands. Calculations of the combined coefficient of metastasizing showed the adenocarcinoma more frequently than other forms to metastasize into the lymph nodes of the chest, adrenals, and kidneys and less frequently into the liver; solid carcinoma with pseudoepidermoid metaplasia metastasizes into the brain more frequently than the other forms. The longest average survival after treatment (radical mastectomy, radiation therapy) was established in a more differentiated form of cancer - adenocarcinoma; the survival time after solid carcinoma and fibrous cancer is considerably shorter.
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PMID:[Metastasis of breast cancer (according to findings of the pathologist of the I. M. Sechenov Moscow Medical Institute I during the 25 year period -- 1951-1975)]. 20 51

The pleural tail sign is widely thought to indicate malignancy. However, of 18 patients with the tail sign, 9 had benign disease. Bronchioloalveolar carcinoma was the most common malignant tumor, but adenocarcinoma, squamous-cell carcinoma, and metastatic adenocarcinoma of the colon were also found. The location of nodules and the radiographic characteristics of the pleural tails did not help differentiate benign from malignant lesions. However, nodules 2 cm or larger were malignant while those 1 cm or smaller were benign. Histologically, pleural tails reflected thickened, fibrotic connective tissue septae with indrawing of the visceral pleura. Their occurrence with neoplasm reflects desmoplastic reaction or scar carcinoma.
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PMID:The pleural tail sign. 20 98

Forty-eight patients with advanced bronchogenic carcinoma were treated with a combination of CCNU and Adriamycin. There was an overall objective response rate of 38%. This consisted of 1 of 12 (8%) patients with epidermoid carcinoma, 5 of 15 (33%) with adenocarcinoma, 2 of 5 (40%) with large cell undifferentiated carcinoma and 10 of 16 (63%) with small cell undifferentiated carcinoma. The overall median survival time (MST) from initiation of therapy was 28 weeks. The MST was 18 weeks for patients with epidermoid carcinoma, 30 weeks for those with adenocarcinoma, 39 weeks for those with large cell carcinoma, and 30+ weeks for those with small cell carcinoma. Objective tumor response was associated with prolonged survival. There were no drug related deaths and toxicity was minimal.
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PMID:CCNU-adriamycin therapy in bronchogenic carcinoma. 20 37

Intraductal carcinomas of the prostate comprise about 3 per cent of all prostatic carcinomas and constitute a heterogeneous group of tumors that include 1) transitional or squamous cell carcinoma, 2) intraductal adenocarcinoma, 3) endometrioid carcinoma and 4) mixed ductal carcinoma. Generally, these tumors are poorly responsive to endocrine and radiation therapy, and complete surgical excision offers the best chance for long-term survival. A case of intraductal adenocarcinoma is presented that illustrates many of the features of these tumors.
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PMID:Surgical considerations in treatment of intraductal carcinoma of the prostate. 20 23

A human gastric carcinoma cell line, KATO-II, and its subline, KATO-III, have been established in vitro from a pleural effusion of a 55-year-old male patient. Kato-II cells have been maintained using a culture medium containing human cord serum and KATO-III cells have been cultured with a medium containing fetal bovine serum. Both cell lines are morphologically quite similar; they grow in vitro floating free and have cytological features of signet ring cells. Population doubling times for KATO-II and KATO-III were 74 hours and 36 hours, repsectively. The modal chromosomal numbers of these cell lines fell in a tetraploid range. Heterotransplantation of KATO-II and KATO-III cells was successfully done in the cheek pouches of antithymocyte serum-treated hamsters. Microscopical appearance of the resultant tumors was consistent with poorly-differentiated adenocarcinoma comparable to the original tumor.
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PMID:Establishment of cultured cell lines derived from a human gastric carcinoma. 20 29

Thirty-seven patients with advanced or recurrent lung cancer were randomized to cytoxan (CTX) alone, COMF (CTX, oncovin, methotrecate and 5-FU) or AMCOF (adriamycin, methotrexate, CTX, oncovin and 5-FU) after receiving radiation therapy to primary and bulky tumor sites. Median survival was 3 months for CTX, 6 months for COMF and 14 months for AMCOF. Analysis of those with cell (small cell) carcinoma showed median survival of 8.5 months. Oat cell cases treated with CTX survived 5 months (8 patients) with COMF 7.5 months (15 patients) and with AMCOF 13 months (14 patients). The median survival of those with adenocarcinoma or epidermoid carcinoma treated with CTX survived 3 months, with COMF 6 months and with AMCOF 15.5 months. Toxicity was moderate though no life-theatening toxicity developed in spite of the protocol design of escalation to achieve some degree of hematologic toxicity in all patients.
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PMID:Combination modality therapy in lung cancer: a survival study showing beneficial results of AMCOF (adriamycin, methotrexate, cyclophosphamide, oncovin and 5-fluorouracil). 20 81

After experiencing intermittent episodes of abdominal pain for two years, a 28-year-old woman developed partial small bowel obstruction. Barium enema and colonoscopy revealed the source of obstruction to be an apparent cecal carcinoma. At exploratory laparotomy a primary adenocarcinoma of the appendix with bilateral Krukenberg ovarian metastases was found. This is a rare occurrence and, to our knowledge, the first well-documented case in the English literature. These case also demonstrates difficulties in the preoperative diagnosis of adenocarcinoma of the appendix.
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PMID:Primary mucinous adenocarcinoma of the appendix with bilateral Krukenberg ovarian tumors. 21 Mar 9

One hundred sixty Mongolian gerbils, Meriones unguiculatus, were examined for the presence of naturally occurring lesions. The first recognized cases of cecal adenocarcinoma, testicular teratoma, and sebaceous gland pad carcinoma were found. Neoplasms previously reported from the gerbil and also seen in the present study included ovarian theca lutein and granulosa lutein cell tumors, sebaceous gland pad adenoma, cutaneous squamous cell carcinoma, malignant melanoma, and renal and splenic hemangiomas. Calcinosis cutis was also observed in two male gerbils.
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PMID:Further observations on spontaneous neoplasms in the Mongolian gerbil, Meriones unguiculatus. 21 Mar 28


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