Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0007095 (
carcinoid
)
6,990
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Regenerating islet-derived family, member 4 (
Reg IV
) is a candidate marker for cancer and inflammatory bowel disease. In the present study, immunohistochemical analysis of
Reg IV
was performed in various human neoplastic (n = 289) and non-neoplastic tissues. In the stomach, foveolar epithelium was negative for
Reg IV
, whereas goblet cells of intestinal metaplasia and neuroendocrine cells at the base of intestinal metaplasia expressed
Reg IV
. Neuroendocrine cells of the small intestine and colon showed strong expression of
Reg IV
, whereas goblet cells of the small intestine and colon showed weak or no expression of
Reg IV
. Insulin-producing beta cells of the endocrine pancreas were positive for
Reg IV
. Among 143 gastric adenocarcinomas,
Reg IV
expression was detected in 42 (29.4%) and was associated with both the intestinal mucin phenotype and neuroendocrine differentiation. No association was found between
Reg IV
expression and clinical characteristics such as tumour stage and patient prognosis. Of 36 colorectal adenocarcinomas, 13 (36.1%) were positive for
Reg IV
, which was associated with tumour stage (p = 0.0379, Fisher's exact test). Expression of
Reg IV
was detected in 14 (93.3%) of 15 colorectal
carcinoid
tumours.
Reg IV
expression was also detected in 5 (21.7%) of 23 ductal adenocarcinomas of the pancreas. In contrast, lung cancers (n = 30) and breast cancers (n = 30) did not express
Reg IV
. This is the first immunohistochemical analysis of the expression and distribution of
Reg IV
protein in human tumours. These data suggest that
Reg IV
is expressed by gastrointestinal and pancreatic tumours, including adenocarcinomas and
carcinoid
tumours, and that
Reg IV
is associated with intestinal and neuroendocrine differentiation of the stomach and gastric carcinoma.
...
PMID:Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. 1608 44
