Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007095 (carcinoid)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-five neuroendocrine tumours and 6 adrenocortical tumours were examined immunohistochemically for the expression of neuron-specific enolase (NSE), chromogranin and synaptophysin. The results were compared with the staining patterns obtained with peanut lectin (PNA) using a streptavidin-biotin staining technique. In separate experiments, sections were preincubated with neuraminidase for the demonstration of masked PNA binding sites. Two of the 24 phaeochromocytomas, 1 of the 6 medullary carcinomas of the thyroid gland, 5 out of the 7 islet cell tumours of the pancreas and all 4 extra-adrenal paragangliomas were negative with PNA. When the sections were first incubated with neuraminidase all these tumours were positive with PNA. Six adrenocortical tumours and 7 neuroblastomas were examined and found to be negative with PNA with or without neuraminidase pre-treatment. Seven carcinoid tumours were examined and found to be positive with PNA only in tubular areas and negative in solid areas; pre-treatment with neuraminidase did not alter the staining pattern. Immunoreactivity for NSE was absent in only 1 of the neuroendocrine tumours. A higher proportion of neuroendocrine tumours was positive with anti-chromogranin than with anti-synaptophysin.
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PMID:Peanut lectin: a histochemical marker for phaeochromocytomas. 171 80

The binding of peroxidase-conjugated Dolichos biflorus (DBA), Triticum vulgaris (WGA), Canavalia ensiformis (Con A), Arachis hypogaea (PNA), Lotus tetragonolobus, and Bandeiraea simplicifolia I (BSAI) to gastrointestinal carcinoid tumours was studied. The results indicate that carcinoid tumour cells express certain carbohydrates similar to those present in the adjacent surface epithelium. The differences in the lectin-binding properties of carcinoid tumours of different sites of the gastrointestinal tract are closely related to the regional differences in the lectin binding of adjacent surface epithelium. These observations therefore form a useful basis for further studies in the application of lectin histochemistry to elucidate the histogenesis of carcinoid tumours.
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PMID:Lectin expression in carcinoid tumours of the gastrointestinal tract. 335 72

Pathology, particularly histology and histogenesis, of thymic neoplasms is reviewed. In this report, thymic neoplasms include thymoma, lymphoma, carcinoid and germ cell tumors (teratoma group) originating from the thymus. Ultrastructures, enzymohistochemistry and immunohistochemistry have increased the knowledge on the relation between the histogenesis, morphology and function of each neoplasm. Recently, various kinds of monoclonal antibodies have easily been available, and the use of them in immunohistochemistry is useful for differentiating the subpopulation of lymphocytes in thymomas. Some interpretations referring to the microenvironment by thymoma cells and developing T lymphocytes are described. We stressed that peanut lectin was useful for identifying cortical thymocytes in paraffin sections, and functions of S-100 protein positive cells in thymomas should be investigated for elucidating one of the questions concerning the microenvironment by thymoma cells.
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PMID:[A pathologic review of thymic neoplasms]. 391 23

Nine patients with mid-gut carcinoid tumours received leucocyte interferon (IFN) i.m. daily for 90 days. Six patients clearly ameliorated in symptoms typical of the carcinoid syndrome (flushing, diarrhoea, asthma) which correlated with reduced serum levels of tumour related polypeptides and urinary output of 5-hydroxyindole acetic acid (5-HIAA). Before IFN treatment, peripheral blood mononuclear leucocytes (PBLs) from carcinoid patients showed markedly deficient production of pH 2 labile IFN-alpha in response to Staphylococcus aureus Cowan I (SACoI) in vitro. In contrast, IFN-alpha responses to the inducers Sendai virus and beta-haemolytic streptococcus group G and IFN-gamma responses to Lens culinaris lectin and concanavalin A were normal. Also, basal and in vitro IFN enhanced natural killer (NK) cell activity and T cell mitogen-induced cell proliferation were similar in patients and controls. During 90 days of IFN therapy, SACoI-induced IFN responses became entirely undetectable. There were transient declines at 1 and 30 days in IFN responses to the other IFN inducers, of mitogen-induced lymphocyte proliferation and of basal NK activities. The increments of NK cell activities after in vitro IFN exposure were clearly decreased in IFN treated patients, suggesting in vivo activation of these cells. Thus, the results demonstrate one remarkable abnormality in carcinoid patients: a deficient IFN response to SACoI and a clear influence of IFN therapy on several parameters of the IFN-NK system.
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PMID:Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon. 661 63