Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007095 (carcinoid)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report a case of carcinoid heart disease secondary to a tumour of the small bowel with liver metastases. There were severe lesions of the endocardium on the right side of the heart, with gross pulmonary and tricuspid incompetence. The left side of the heart did not escape but the fibrous plaques were limited to the papillary muscle of the mitral valve, and had no effect upon the haemodynamics. The pathogenesis of the strange cardiac lesion may be partly explained in terms of the toxicity to the endothelium of bradykinin. In spite of the serious nature of the valvular damage is it right to consider surgical correction, bearing in mind the fact that the prognosis of carcinoid syndrome is still very poor despite treatment?
Arch Mal Coeur Vaiss 1977 Nov
PMID:[Carcinoid heart disease secondary to a tumor of the small intestine. Apropos of a case with associated tricuspid and pulmonary insufficiency]. 14 56

The case is reported of carcinoid heart disease in a lady of 70 with intractable congestive cardiac failure 5 years after the removal of a primary carcinoid tumour of the ovary. The special features of primary carcinoid tumours of the ovary are recalled, with emphasis on their rarity and of the absence of liver metastases. The various features of carcinoid syndrome are recalled in the light of current knowledge of the pathogenesis. A review of the literature on cardiac involvement in primary carcinoid tumours of the ovary, amounting to 10 cases, is included. The possibility of surgical cure of the heart lesions in carcinoid tumour by a prosthetic tricuspid valve are discussed, in the light of the 6 reported cases and the present one. Our report is the first one of replacement of the valve after removal of a primary ovarien carcinoid tumour, and the excellent result has been maintained after three years.
Arch Mal Coeur Vaiss 1978 Jan
PMID:[Severe tricuspid insufficiency and primary carcinoid tumor of the ovary. Long term success after valve replacement. Apropos of a case]. 41 76

The authors report a case of carcinoid of the small intestine with liver metastases in whom the entire right side of the heart was affected, with severe tricuspid incompetence and pulmonary stenosis. The extent of the fibrosis, which affected all three layers of the heart on the right side has lead the authors to reconsider the various factors which cause the heart failure in carcinoid syndrome. This must now be included in the wider category of APUD. The severity of the tricuspid lesions compared with the derangement of the valvular and subvalvular structures makes an argument in favour of surgical correction.
Arch Mal Coeur Vaiss 1976 Jul
PMID:[Carcinoid of the small intestines with right cardiac involvement. Clinical, phonomechanographical hemodynamic and anatomical study]. 82 47

The joint manifestations of carcinoid tumours become integrated into the carcinoid syndrome, the totality of the symptoms occurring at a distance from the tumour and linked to the metabolites secreted by the tumour. These arthropathies have been the subject of only a very limited number of publications. They consist of arthralgia, sometimes with swelling, predominantly in the extremities of the upper limbs, and linked to activity. The radiological picture includes a "band" of demineralization, and less frequently destructive joint lesions. The sedimentation rate is always increased. These arthropathies can be related to their origin only by knowledge of, and demonstration of, the other elements of the carcinoid syndrome and of the tumoro-metastic syndrome. Laboratory diagnosis rests on determination of the 5-hydroxyl derivatives of tryptophane.
Rev Rhum Mal Osteoartic 1976 Oct
PMID:[Joint manifestations of carcinoid tumors of the digestive system]. 98 23

The authors report the case of a 35-year-old woman undergoing surgery in 1976 for a bronchial carcinoid tumour, considered to be benign. Twelve years later, diagnostic evaluation of liver metastases led to the discovery of an asymptomatic lesion of D10, the CT scan and NMR appearances of which were suggestive of osteonecrosis, a diagnosis confirmed histologically. Investigations were repeated 2 years later because of spinal pain. While NMR and CT scan remained compatible with bone necrosis, biopsy on this occasion confirmed the presence of carcinoid tumour. These rare tumours metastasise little. Secondary bone deposits, essentially axial, are of an osteoblastic nature. The lesion seen in our patient was closer to idiopathic bone infarcts or those associated with Gaucher's or sickle cell diseases than to classical vertebral osteonecrosis. The relationship between vertebral necrosis and metastasis remains obscure.
Rev Rhum Mal Osteoartic 1992 Feb
PMID:[Osteonecrosis, metastases and bronchial carcinoid]. 160 26

The authors report four cases of hypercalcemia occurring during the course of carcinoma of the prostate. This association is rare (less than twenty published cases) though not exceptional, carcinoma of the prostate accounting for almost 4 per cent of causes of malignant hypercalcemia. This generally involves advanced and metastatic forms, at the terminal phase, but cases of regression after hormone therapy have been reported. The histological type of the tumour is unusual in one case in two (anaplastic or carcinoid). The mechanism of this hypercalcemia is humoral, probably by secretion of a parathormone-like peptide, but which has not yet been fully elucidated.
Rev Rhum Mal Osteoartic 1991 Mar
PMID:[Hypercalcemia in cancers of the prostate. Apropos of 4 cases]. 205 91

We report a case of a 62 year old man who presented with effort dyspnoea accompanied by a cough and haemoptysis. The chest radiograph of the thorax showed atelectasis of the right upper lobe. Bronchoscopy showed evidence of a tumour like mass obstructing the right bronchus and this revealed itself to be a mass of organised fibrinous deposit in granulation tissue containing numerous colonies of Aspergillus. In fact it appeared to be an obstructive Aspergillus bronchitis, with a pseudo-tumour appearance attached to a carcinoid tumour which was obstructing the apical segment of the right upper lobe. Obstructive Aspergillus bronchitis makes up only a small percentage of overall respiratory disease caused by Aspergillus. They pose a problem of differential diagnosis with bronchopulmonary aspergillosis which is much more frequent.
Rev Mal Respir 1990
PMID:[Endobronchial aspergillosis associated with a carcinoid tumor]. 227 Mar 53

We report a case of carcinoid heart disease which was remarkable on three scores: --the value of echocardiography which enabled us to diagnose the disease; --the usefulness of cardiac doppler examination which provided non-invasive haemodynamic evaluation of lesions of the four valves; --the presence of moderate involvement of the right heart, which is classical from the point of view of anatomopathology but is often missed clinically and was ascertained in that case by doppler-echocardiography.
Arch Mal Coeur Vaiss 1989 Jan
PMID:[Demonstration by Doppler echocardiography of multiple valvular involvement in carcinoid cardiopathy]. 249 62

In a retrospective series of 960 cases of tricuspid regurgitation studied by two-dimensional echocardiography 6 patients presented a systolic defect of valvular coaptation. The origin of this defect varied: one case was due to carcinoid, two to rheumatic cardiopathy, two to papyraceous right ventricle and one to sclerodermia associated with pulmonary arterial hypertension. The mechanism of the lacking coaptation varies according to the etiology: valvular retraction in carcinoid cardiopathy, right-ventricle dilatation, dilatation of the tricuspid ring and altered kinetics of the right ventricle in the other cases. Changed contractility of the right ventricle is the only element allowing to distinguish tricuspid regurgitation with and without a coaptation defect. Clinically this abnormality always points to an advanced stage of severe tricuspid regurgitation.
Arch Mal Coeur Vaiss 1986 Sep
PMID:[Major tricuspid insufficiency and absence of systolic valvular coaptation. Echocardiographic study. Apropos of 6 cases]. 309 83

The carcinoid tumour of the thymus was first detailed by Rosai in 1972. The authors describe three cases of this tumour with particular reference to their histogenesis. It appears to be a tumour predominantly affecting males with an often unfavourable, though slow, progression. Some pathological associations are frequent and characteristic. In one third of cases there is an associated endocrine neoplasia. As a rule the tumour is sited in the anterior mediastinum. The precise diagnosis rests on histochemical criteria (specific granulations). These carcinoids are tumours of the APUD system of endodermal origin. The treatment is surgical.
Rev Mal Respir 1984
PMID:[Thymic carcinoid tumors. A clinico-anatomic study of 3 cases]. 615 52


1 2 3 Next >>