Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007095 (carcinoid)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 71 patients has been reported in the English literature to have developed carcinoid tumors in the fundus of the stomach in association with chronic atrophic gastritis secondary to pernicious anemia. The tumors appear to develop from argyrophilic cells in response to hypergastrinemia produced by hyperplastic G cells in the antrum of the stomach. We report a similar patient who, in addition, had a neuroendocrine tumor develop in the neck of the pancreas, which obstructed the pancreatic duct and resulted in severe chronic pancreatitis in the body and tail of the gland. There was an associated splenic vein thrombosis with left-sided portal hypertension. The pancreatic neoplasm was treated by excision, including the caudal 85 per cent of the pancreas and spleen. The gastric carcinoids appeared to diminish in size in response to a octreotide acetate (Sandostatin, Sandoz Pharmaceuticals; Hanover, NJ) administered to promote closure of a low-volume postoperative pancreatic fistula. The gastric lesions may require surgical treatment in the future. We were unable to find other examples of pancreatic neuroendocrine tumor occurring in association with pernicious anemia in a search of the English literature.
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PMID:Neuroendocrine tumor of the pancreas in a patient with pernicious anemia. 235 Jan 7

A 61-year-old white man was found to have granulomatous myocarditis associated with a carcinoid tumor in the ileum with local lymphatic metastasis, a mixed papillary and follicular carcinoma of the thyroid with regional lymph node metastasis, benign tubular cell adenomas of the kidneys, and chronic pancreatitis.
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PMID:Granulomatous myocarditis with unusual histologic features. 277 89

The incidence of chronic pancreatitis has been increasing in the western world. Although chronic alcohol abuse accounts for 90% of adult cases, the physician must be aware of the multiplicity of causes for chronic pancreatitis. We present a case of obstruction of the pancreatic duct and chronic pancreatitis caused by a primary carcinoid tumor.
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PMID:Chronic pancreatitis and pseudocyst formation secondary to carcinoid tumor of the pancreas. 335 Feb 92

Primary carcinoid tumors of the pancreas are exceedingly rare, only few cases have been reported in the literature. We present a case of primary carcinoid tumor of the pancreas occurring on chronic pancreatitis. The CT, as well as endosonographic features are described. Those two techniques might contribute to an early preoperative diagnosis which is important since carcinoid tumors have a better prognosis than the common pancreatic adenocarcinoma.
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PMID:[Primary carcinoid tumor of the pancreas. X-ray computed tomographic and echo-endoscopic aspects]. 836 Aug 64

A 60-year-old female with a history of chronic pancreatitis and previous pancreaticojejunostomy has been submitted to distal gastric resection for recurrent perforating ulcers. A carcinoid tumour was identified in the surgical specimen. Hypergastrinaemia was subsequently diagnosed and tumour localization was carried out by a new scintigraphic technique with 111In-Pentetreotide. The tumour was found to be a metastasis confined to a peripancreatic lymph node. Surgery was successful, and 6 months later the patient is still eugastrinaemic. The different imaging methods for the identification of gastrinomas are discussed together with the current therapeutic options.
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PMID:Changing approach to gastroenteropancreatic tumours. Case report of a gastrinoma metastasis localized by somatostatin-receptor scintigraphy. 884 38

This is a case report of a patient with an initial diagnosis of chronic pancreatitis who actually had metastatic carcinoid tumor. His symptoms of abdominal pain, weight loss, and diarrhea were manifestations of the large tumor bulk within the liver as well as carcinoid syndrome. Although abdominal CT scans showed multiple liver lesions, the primary lesion was not identified by conventional imaging studies. However, the mid-gut primary lesion was visualized on in-111 labeled octreotide scintigraphy; where the liver lesions were better delineated and seen to be separate from the normal pancreas when the Tc-99m sulfur colloid images were compared to the octreotide images.
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PMID:In-111 labeled octreotide imaging of a primary carcinoid lesion undetected by conventional imaging studies in a patient with "chronic pancreatitis". 885 17

Carcinoid tumors are common in the duodenum except for in the Vater's papilla [1-9]. We report here a case of carcinoid tumor arising in the Vater's papilla with repeated episods of pancreatitis. The patient is a 28 year-old-woman who had repeated abdominal pain with elevated serum amylase and had been treated as chronic pancreatitis. Computed tomography (CT) revealed a slight dilatation of the main pancreatic duct from the pancreatic head to the tail, and mild swelling of the pancreas. A submucosal tumor measuring 1.3 cm in diameter was detected in the ampulla of Vater by esophagogastroduodenscopy (EGD), and total papillectomy was performed under the suspicious of carcinoid tumor. The tumor was not encapsulated, 1.0 cm in diameter, undefined, and whitish in color. Histologically monomorphic tumor cells with lightly eosinophlic cytoplasm and round nuclei proliferate in trabecular and solid patterns. Immunohistochemically tumor cells were positive for neuron-specific enolase, chromogranin A and synaptophysin, and the tumor was diagnosed as carcinoid tumor. It should be noted that carcinoid tumor in the ampulla may occur with initial signs of acute or chronic pancreatitis.
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PMID:Carcinoid tumor of the Vater's papilla presenting with chronic pancreatitis--a case report--. 1642 77

Short-term results of 124 pancreatoduodenal resections (PDR) are analyzed. 65,3% of patients had pancreatic cancer, 12,1% - cancer of the papilla Vateri, 3,2% - cancer of the terminal part of the common bile duct, 2,4% - cancer of the duodenum, 2,4% carcinoid of the pancreas, 14,5% - chronic pancreatitis with the affection og the head. Standard Whipple procedure performed in 91 patients, pyloro-saving PDR - in 32 cases and total pancreatoduodenectomy in one patient. 3 types of pancreatic stump preparation were used. Pancreatojejunal anastomosis (PEA) (n=63) considered to be the first, pancreatogastroanastomosis (PGA) (n=46 ) - the second and external pancreaticostomy (n=15) - the third. Overall anastomosis failure rate was 12,1% (n=15). By PEA, failure rate was 27,5% and was noticed predominately in cases of connecting all area of pancreatic slice with the gut (43,5%). PGA failure rate was 2,1% (n=1). Therefore, PDA should be considered to be a reliable pancreatodigestive anastomosis, allowing a decrease of postoperative complication rate to 26,1% and lethality rate to 2,1%.
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PMID:[Pancreatic stump preparation by pancreatoduodenal resection]. 1977 Aug 22