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Query: UMLS:C0006826 (cancer)
 1,092,456 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Depressive symptoms assessed by the Beck Depression Inventory were compared in 97 cancer patients, 66 next-of-kin of cancer patients, and 99 physically healthy persons who attempted suicide. Less than a fourth of the cancer patients and a fifth of their next-of-kin but over half of the psychiatric patients were moderately or severely depressed. The two patient groups were indistinguishable in somatic depressive symptoms, both scoring higher then the next-of-kin. The cancer patients and the next-of-kin were indistinguishable in nonsomatic (psychological) depressive symptoms, both scoring lower than the suicide attempters. Younger patients reported more nonsomatic symptoms than older ones. Beck scores and nearness to death were not associated in 57 cancer patients who expired. Vegetative depressive symptoms in cancer patients may reflect advanced disease, but nonsomatic symptoms should be reason for psychiatric consultation.
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PMID:Comparative studies of psychological function in patients with advanced cancer--I. Self-reported depressive symptoms. 89 49

Increased survival rates resulting from advances in the treatment of cancer have led to an increased interest in patients' emotional reactions and adaptations to the illness. Depressive symptoms associated with cancer range from normal sadness through acute stress response to major depression. Chemotherapeutic agents can produce depressive and other neurotoxic side effects. Diagnosis of common emotional reactions to cancer illness and appropriate management are described. Such treatment can enhance the patient's ability to adapt to the disease and tolerate its treatments.
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PMID:Diagnosis and treatment of depression in the cancer patient. 669 49

A physician describes and comments on the case of a middle-aged couple in which the husband requests that his wife not be told she has an incurable malignancy. When the wife finally confronts the doctor and demands the truth, her emotional depression is lifted and she dies soon afterward.
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PMID:Truth at the last--a case of obstructed death? 706 36

Thirty-eight patients with nonseminomatous testicular cancer were treated with cis-platinum, bleomycin, and vinblastine in combination without a prolonged maintenance phase. Twenty-Six patients with Stage III disease were treated. Seventy-six percent of those patients treated achieved complete remission. At a median survival time of 30 months, no patient who achieved a complete remission has relapsed. Twelve Stage II patients given adjuvant therapy remain free of disease at a median time of 23 months. Markedly elevated serum lactate dehydrogenase levels and massive disease were common findings in the patients who did not achieve complete remission. One drug death occurred secondary to sepsis. Symptoms of depression and anxiety were significant dose-limiting factors in this group of patients.
Cancer 1981 Sep 01
PMID:Treatment experience with nonseminomatous testicular cancer in patients with stage II and stage III disease. 719 96

This research was done to describe the nature and degree of psychological distress persons experience after receiving a diagnosis of colorectal cancer and to describe the effect on functional dependency of that distress during the first 3 months of treatment. The sample consisted of 66 persons who completed interviews before surgery and 1 and 3 months after surgery. Depressive symptoms changed substantially over time in relation to the events of diagnosis and treatment. Having an ostomy, additional treatment, and depressive symptoms were predictors of functional dependency after surgery. The findings suggest that depressive symptoms, even at low levels, are important to address because they may reduce patients' ability to function in their usual roles and activities for considerable periods after colorectal cancer surgery.
Cancer Pract
PMID:Psychological distress and functional dependency in colorectal cancer patients. 770 67

Symptoms of depression and anxiety were measured in a prospective follow-up study of 36 cancer patients before and during chemotherapy by means of the Hamilton rating scales and the Melancholia Scale. These scales proved useful in the examined population. Moderate or severe depression was seen in almost half of the patients before chemotherapy, but this figure decreased during follow-up. The symptomatology resembled that of primary depression, and the brief rating scales for depression seemed suitable for screening purpose. Problems in identifying morbid states of anxiety and depression are discussed.
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PMID:[Symptoms of depression in cancer patients undergoing chemotherapy]. 772 62

The constructs of repressive adaptive style and avoidant coping (blunting) were assessed as possible explanatory factors for previously reported findings of lower self-reported depression in children with cancer. Pediatric oncology patients 7-16 years old (n = 107) and healthy control participants (n = 442) completed measures of depressive symptoms, trait anxiety, defensiveness, and approach and avoidant coping. Oncology patients scored significantly lower on measures of depression and trait anxiety, and higher on defensiveness. Applying the adaptive style paradigm, the oncology group showed a significant excess of repressors. Depressive symptoms differed as a function of adaptive style, with repressors demonstrating the lowest levels of self-reported depression. Children with cancer also reported greater use of blunting, but this difference was small and appeared unrelated to depression scores. Within the cancer group, repressive adaptation was unrelated to time elapsed since diagnosis. These findings are discussed with reference to the ongoing controversy regarding cancer-personality style associations.
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PMID:Repressive adaptation in children with cancer. 938 97

Depressive symptoms, social competence, and behavior problems of prepubescent children bereaved within 18 months of parental death from cancer (57 families, 64 children) or suicide (11 families, 16 children) were compared. Most children reported normative levels of depressive symptoms. Children whose parents died from suicide, compared with those whose parents died from cancer, reported significantly more depressive symptoms, involving negative mood, interpersonal problems, ineffectiveness, and anhedonia. Parental reports of children's competence and behavior were similar to a normative sample of children and did not differ between the children bereaved by parental cancer or suicide. Additional research should focus on other factors, such as family psychopathology, stresses, and impact of stigma, which may influence the course of bereaved children.
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PMID:Child survivors of parental death from cancer or suicide: depressive and behavioral outcomes. 1066 54

Some patients with advanced cancer express the wish for an early death. This may be associated with depression. We examined the relations between depressive symptoms and desire for early death (natural or by euthanasia or physician-assisted suicide) in 142 terminally ill patients with cancer being cared for by a specialist palliative care team. They completed the Hospital Anxiety and Depression Scale questionnaire and answered four supplementary questions on desire for early death. Only 2 patients expressed a strong wish for death by some form of suicide or euthanasia. 120 denied that they ever wished for early release. The desire for early death correlated with depression scores. Depressive symptoms were common in the whole group but few were on antidepressant therapy. Better recognition and treatment of depression might improve the lives of people with terminal illness and so lessen desire for early death, whether natural or by suicide.
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PMID:Relations between desire for early death, depressive symptoms and antidepressant prescribing in terminally ill patients with cancer. 1235 85

Sadness is a normal reaction to the fears, anxieties, and uncertainties during any stage of cancer but is especially problematic during the advanced stage. Depressive symptoms and syndromes frequently coexist during this time and affect quality of life. Depression is an overlooked and undertreated symptom during late-stage cancer. This article provides an overview of the epidemiology, neurophysiology, diagnostic and screening approaches, risk factors, and treatment modalities for depression in patients with advanced cancer.
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PMID:Depression in patients with advanced cancer. 1279 34


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