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Query: UMLS:C0006826 (cancer)
 1,092,456 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electromyographic studies were performed on 16 patients with intractable low back pain and no antecedent history of malignancy or metastatic disease. In each case, electromyographic evidence of severe segmental denervation limited to the paraspinal muscles innervated by the posterior primary rami was found. Subsequent diagnostic studies in each patient revealed a primary neoplasm or tumor metastasis as the source of pain. Applying current knowledge of neuromuscular physiology, the electromyograph may prove to be a valuable aid to the early detection of remote metastasis to the spine and paraspinal muscle structures.
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PMID:Electromyographic findings in patients with low back pain due to unsuspected primary and metastatic spinal or paraspinal muscle disease. 645 39

Fifty-two patients, admitted to a pain relief unit, had a cannula placed in the radial artery to measure the paO2, paCO2 and pH of arterial blood every 2 h, for periods ranging from 12 to 24 h. The patients were divided into 3 groups: 14 had low back pain, 21 patients had pain from cancer, and 17 had pain from other causes. Twenty were male and 32 were female with a mean age of 53 years (range 16-82 years). The mean paO2 of these groups was within normal limits. The mean paCO2 and pH for the 3 groups were, low back pain paCO2 4.1 kpa, pH 7.42, others, paCO2 4.2 kpa, pH 7.42. The finding of a normal pH associated with a low paCO2 suggests that patients were "reset" to a low paCO2. Treatment, which was most commonly nerve blocks, resulted in marked pain relief in 30 patients. Ten of these patients were available for follow-up at least 1 week later (4 from the low back pain group, 6 from the cancer group), and in every patient, after pain relief, there was a rise in paCO2 which was statistically significant (P less than 0.001) and was not accompanied by a fall in pH. This suggests that intractable pain is accompanied by chronic hyperventilation and that the relief of pain is accompanied by a decrease in ventilation.
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PMID:Ventilatory response to intractable pain. 645 56

Years ago a 20-year-old patient presented with low back pain. Radiologically a cystic lesion of the sacrum was found and interpreted as malignant tumor. Without biopsy and histological diagnosis the patient was given radiation therapy with 21 000 rad. One year later a similar lesion was radiated in the left femoral neck. A pathological fracture ensued recessitating several operations. Twenty years after initial radiation therapy the patient developed a rapidly growing tumor of the sacrum, metastasizing to the lungs. One year later he died.
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PMID:Radiation induced osteosarcoma of the sacrum following radiation of an undiagnosed bone lesion. 658 57

A 53-year-old woman was admitted to our hospital because of genital bleeding. The clinical diagnosis was cancer of the corpus uteri with much ascites. During the course of 10 months of illness, she complained of low back pain, so we diagnosed the sacral metastasis by scintigram. Autopsy examination revealed simultaneous triple malignancies of the right ovarian cancer, the sacrococcygeal chordoma, and the thyroid cancer. Histologically, the ovarian cancer was papillary cystadenocarcinoma with widespread metastases. The chordoma invaded the bone marrow of the sacrum. The thyroid cancer was follicular carcinoma without metastasis. This combination is very rare.
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PMID:[Autopsy case of simultaneous triple malignancies--ovarian, chordoma and thyroid cancers]. 663 20

Metastases of malignant tumor to the kidney are observed rather frequently at autopsy, but rarely found in living patients. Two cases of metastatic renal tumor were found at our clinic. One was a 35-year-old male with esophageal tumor. Five months after on operation for the esophageal tumor, he had asymptomatic macroscopic hematuria and had urological examinations at our clinic. X-ray and ultrasonographic examinations suggested a metastatic tumor in the left kidney. Left nephrectomy was performed. Pathohistological examination revealed a metastatic esophageal tumor in the kidney. Five months after the nephrectomy, right lumbago and macroscopic hematuria appeared. Metastatic right renal tumor was diagnosed with X-ray and ultrasonographic examination. Chemotherapy was conducted, but he died three months later. The other case was a 69-year-old male with left lung cancer (squamous cell carcinoma) who had left partial pneumonectomy . In the second year after the operation, he developed asymptomatic hematuria. After X-ray examinations and 67G -citrate scanning, a metastasis to the right kidney was diagnosed. No special treatment for the metastasis was given to the patient because of his failing condition. He died four months later. Metastatic renal tumors present a worse prognosis than primary renal cancer. This seems to be because the former progresses rapidly after its discovery. When a patient with a previous history of malignant tumors in any organ develops hematuria or lumbago, detailed examinations of the kidney should be performed.
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PMID:[Metastatic renal tumor]. 667 3

A 57-year-old white female, operated on for a prolapsed disc six years ago, presented with low back pain. Initially, she was thought to be suffering from the same disc problem, and was treated accordingly. However, her condition worsened. A myelogram disclosed a complete block of the subarachnoid space from levels T11 to L2. Laminectomy and decompression were performed, revealing tumor in the extradural space. Histological examination disclosed a primary, poorly differentiated lymphocytic lymphoma of the spinal cord. Both primary and metastatic non-Hodgkin's lymphoma of the spinal cord are extremely rare. Mullins et al described only five instances of cord compression in a study of 529 cases of non-Hodgkin's lymphoma. The diagnosis is generally not suspected until laminectomy.
CA Cancer J Clin
PMID:Non-Hodgkin's lymphoma of the spinal cord. 676 33

A case of a cauda equina paraganglioma in a 13-year-old boy is described. A review of literature revealed six similar reported cases. All were intradural extramedullarly tumors located in the cauda equina-filum terminale region. In all, the presenting and dominant symptom was low back pain, while neurologic deficit was mild or absent. Excessive CSF protein levels appeared to be a characteristic feature of the disease. Histologically, the tumor displayed the typical "Zellballen" pattern, however mild nuclear pleomorphism and some mitotic figures were noted. As it is impossible to predict the biological behaviour of paragangliomas from the histologic appearance, complete surgical resection with close follow-up is indicated in such cases.
Cancer 1983 May 15
PMID:Paraganglioma of cauda equina. A report of a case and review of the literature. 683 56

A 52-year-old man, who had been treated for left mega-hydronephrosis (5.6L) 25 years ago in our hospital, recently complained of left lumbago and fever. An abdominal CT scan revealed a cystic mass partially surrounded by calcification in the retroperitoneal space, which appeared to be a hydronephrosis. Percutaneous puncture of the cystic mass was performed and 670 ml, brownish-yellow purulent fluid containing a high level of CA19-9 (over 10,000 U/ml) was obtained. Cytologic diagnosis of the fluid revealed class II cells. Within 7 months after the puncture, recurrence developed twice. Percutaneous instillation of 95% ethanol or Minocycline hydrochloride was instilled, but neither of them prevented recurrence. Ultimately, excision of the cystic mass was performed. Histopathological findings of the cystic mass showed no evidence of malignancy. The patient is follow-up with periodic CT scan showed no evidence of recurrence for more than 3 years.
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PMID:[A retroperitoneal cyst with elevated level of CA19-9 in its content]. 747 12

Malignant diseases and the resulting disorders may lead to the prescription of physical therapy. In addition, cancer patients may suffer from orthopaedic diseases which are treated by physical therapy, e.g. low back pain. In this review, cancer epidemiology, the prevailing forms of physical therapies, their applications in cancer patients, and possible cautions are being discussed.
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PMID:[Physical therapy in cancer patients]. 751 59

Stiff-man syndrome is a rare neurologic disorder characterized by progressive, fluctuating muscle rigidity with painful muscle contractions affecting predominantly the back and proximal extremities. In the ED, the diagnosis can be easily overlooked and misdiagnosed as acute or chronic low back pain and muscle spasm. This syndrome is often associated with diabetes, autoimmune diseases, and cancer. This report describes an illustrative case of a 39-year-old woman who presented to the ED with a two-year history of right leg spasms and low back pain that had become so severe in the preceding two days that she was unable to ambulate. Clues to the patient's proper diagnosis coincide with the diagnostic criteria for stiff-man syndrome: the presence of a slowly progressive stiffness of the axial muscles and proximal limb muscles, making ambulation difficult; hyperlordosis of the lumbar spine; episodic spasms precipitated by jarring or sudden movement; a normal intellectual, sensory, and motor examination when not in spasm; and a marked amelioration of symptoms with the IV administration of diazepam. High-dose oral diazepam is the maintenance drug of choice.
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PMID:Stiff-man syndrome: case report. 758 54


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