Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0006142 (breast cancer)
160,383 document(s) hit in 31,850,051 MEDLINE articles (0.08 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
estrogen receptor 11340
Sep 9613
Mol 8817
HER2 7340
p53 5022
BRCA1 4465
progesterone receptor 4298
epidermal growth factor receptor 4171
aromatase 3301
hormone receptor 2709
BRCA2 2591
nodal 2280
AKT 1715
Bcl-2 1639
PI3K 1579
neu 1547
erbB-2 1507
caspase-3 1495
E-cadherin 1479
oestrogen receptor 1389
mTOR 1380
cyclin D1 1353
EGFR 1353
cytokine 1338
insulin 1324
tyrosine kinase 1315
p21 1277
Ki-67 1265
MRI 1199
MAPK 1182
epidermal growth factor 1138
vascular endothelial growth factor 1123
She 1097
ERK 1038
PARP 1035
CD44 1028
collagen 1019
histone 984
NMR 982
catenin 905
estrogen receptor alpha 840
ERK1 834
cage 805
PTEN 793
ATP 756
prolactin 740
VEGF 725
androgen receptor 710
p38 700
EGF 690
matrix metalloproteinase 672
P-glycoprotein 671
TNM 665
Aromatase 661
Estrogen receptor 643
vimentin 637
STAT3 627
CD24 625
ERBB2 609
proteasome 597
glycoprotein 595
pS2 585
insulin-like growth factor 585
IL-6 582
ACS 581
CD8 580
receptor tyrosine kinase 575
p27 574
MMP-9 570
TNF 557
CDK4 546
PIK3CA 545
fibronectin 516
ubiquitin 514
UTR 504
endoplasmic reticulum 501
ESR1 493
tumor necrosis factor 484
urokinase-type plasminogen activator 479
caspase-9 478
more...
Disease
breast cancer 160383
cancer 73177
tumor 44093
MCF 15455
metastases 10569
carcinoma 9634
tumor growth 5661
tumorigenesis 4758
metastatic breast cancer 4590
tumor progression 4330
carcinogenesis 4139
lung cancer 3608
ovarian cancer 3583
prostate cancer 3352
melanoma 2756
primary tumor 2504
colorectal cancer 2105
ductal carcinoma in situ 1948
adenocarcinoma 1850
ductal carcinoma 1777
colon cancer 1773
mammary tumor 1767
obesity 1765
leukemia 1726
bone metastases 1475
endometrial cancer 1421
cervical cancer 1372
gastric cancer 1363
osteoporosis 1276
aggressiveness 1170
hepatocellular carcinoma 1152
diabetes 1082
lymphoma 1017
depression 1014
carcinoma of the breast 941
pancreatic cancer 855
lymphedema 850
non-small cell lung cancer 821
neutropenia 818
cardiovascular disease 783
uterus 769
brain metastases 702
multiple myeloma 694
Hodgkin's disease 656
liver cancer 634
invasive cancer 621
ATM 581
squamous cell carcinoma 571
hypertension 562
lung metastases 532
renal cell carcinoma 520
tumor angiogenesis 505
liver cancer 501
anemia 496
glioblastoma 492
sarcoma 483
carcinoma of the breast 473
recurrent breast cancer 464
bladder cancer 458
solid tumor 444
retinoblastoma 443
glioma 437
inflammatory breast cancer 435
residual disease 428
Luminal 424
stroke 420
liver metastases 414
epithelial ovarian cancer 406
infiltrating ductal carcinoma 405
lung carcinoma 399
EMT 398
osteosarcoma 388
myelosuppression 386
thrombocytopenia 379
tumor initiation 369
acute myeloid leukemia 367
SCID 358
thyroid cancer 358
renal cancer 352
neuroblastoma 348
more...
Symptom
pain 1757
fatigue 837
nausea 644
overweight 482
vomiting 479
menopausal symptoms 409
diarrhea 400
anesthesia 324
nausea and vomiting 324
bone pain 278
hot flashes 277
hot flushes 277
discomfort 235
headache 200
dyspnea 199
nipple discharge 199
nipple discharge 188
starvation 187
discomfort 180
weakness 167
erythema 153
anorexia 151
arthralgia 141
insomnia 113
collapse 97
constipation 93
myalgia 92
abdominal pain 91
cough 85
analgesia 83
numbness 82
cachexia 81
asthenia 76
back pain 71
paresthesia 65
mastalgia 65
ataxia 56
stigma 53
cancer pain 53
seizures 52
exhaustion 51
sleepiness 51
night sweats 49
chills 48
dizziness 48
Ill 47
chest pain 46
HSA 42
shortness of breath 36
acidity 34
hopelessness 33
angina 31
flushing 30
peri-menopausal 28
thinning 27
low back pain 27
lethargy 27
vertigo 23
myoclonus 22
memory loss 20
masculinization 20
breast hyperplasia 20
shoulder pain 19
irregular bleeding 19
respiratory distress 18
cerebellar ataxia 18
Depressive symptoms 17
splenomegaly 17
tremor 17
acute pain 17
peau d'orange 16
epigastric pain 16
neck pain 16
Scratch 16
agitation 16
syncope 15
Breast pain 15
distraction 15
arm pain 14
decreased appetite 14
more...
Drug
Herceptin 1323
ICI 608
MAP 540
lysine 532
ROS 470
Adriamycin 401
Taxol 393
EE2 369
Estrogens 353
ADR 340
Docetaxel 335
CSF 304
CTX 285
ROC 263
Raloxifene 248
G-CSF 244
vitamin E 238
Fulvestrant 234
DM1 199
IL-2 197
Dermatol 193
uPA 171
IFN-gamma 165
Monit 160
ascorbate 140
CTX 133
Paraffin 130
ADM 128
Taxotere 127
Cardiovasc 126
Zoledronic acid 126
Mutagen 119
GEO 119
Bevacizumab 118
ABC 118
Arimidex 116
Gel 116
Zoledronic acid 101
NADH 100
caffeine 95
Vinorelbine 94
Gefitinib 91
Pertuzumab 76
Everolimus 72
Retinoic acid 71
CTX 67
ETS 66
Leaf 61
Zoladex 60
TAT 60
CAM 59
Asn 57
TAC 56
Denosumab 56
MRC 54
Norplant 53
CTC 52
CTC 51
Femara 50
Zoladex 50
NVP 49
Ixabepilone 49
Vitamin E 49
Glutathione 48
ZnO 47
Albumin 47
Tibolone 44
ENT 43
Cetuximab 43
Spectrum 43
Fluorescein 43
Depo-Provera 40
Cremophor EL 38
Bortezomib 38
citric acid 37
PTH 36
DNase I 36
Alliance 34
Imatinib 34
BLM 33
more...
Enzyme
ERK 10031
mitogen-activated protein kinase 3003
luciferase 1470
focal adhesion kinase 1457
protein kinase 1289
caspase-3 1126
PARP 1122
P-glycoprotein 677
proteasome 606
MEK 600
ACS 581
urokinase-type plasminogen activator 562
protein kinase C 484
cdc2 424
reverse transcriptase 418
phosphatidylinositol 3-kinase 412
caspase-9 387
cathepsin D 385
topoisomerase 374
topoisomerase 355
glutathione S-transferase 354
alkaline phosphatase 341
catalase 304
peroxidase 302
caspase-8 298
ATPase 292
AMP-activated protein kinase 283
phosphoinositide 3-kinase 261
RNA polymerase 259
superoxide dismutase 232
lactate dehydrogenase 208
AMPK 202
trypsin 193
collagenase 187
APC 179
DNA methyltransferase 174
AMPK 173
GSK 170
sulfatase 161
MMP 156
aldehyde dehydrogenase 152
aldehyde dehydrogenase 151
aldehyde dehydrogenase 148
aldehyde dehydrogenase 148
aldehyde dehydrogenase 148
RNase 143
calcineurin 140
RNase 137
glutathione peroxidase 137
thymidylate synthase 128
NQO1 126
MDR 125
thymidine kinase 123
alanine aminotransferase 120
IKK 120
prostate-specific antigen 119
thrombin 115
cathepsin B 110
CYP3A4 108
aspartate aminotransferase 108
MAP 105
caspase-7 105
caspase-7 105
demethylase 98
DNA polymerase 97
ALDH 93
matrix metalloproteinase 9 92
glyceraldehyde-3-phosphate dehydrogenase 91
phospholipase C 89
ornithine decarboxylase 86
NOS 85
plasmin 84
dihydrofolate reductase 82
thymidine phosphorylase 76
transcriptase 75
PDK1 75
beta-galactosidase 74
matrix metalloproteinase 2 72
tissue plasminogen activator 71
hyaluronidase 68
more...
Compound
DNA 12556
MDA 11788
Dec 10690
Clin 9775
oxygen 2227
Tamoxifen 2083
MTT 2039
Tamoxifen 2027
tyrosine 1528
water 1424
calcium 1390
Estrogen 1363
Estrogen 1360
acetate 1189
glucose 1188
Pac 895
PEG 871
Adriamycin 820
ADR 791
ATP 759
serine 743
lysine 697
phosphate 692
sulfate 683
sodium 664
TNM 663
iron 615
PEG 611
ICI 610
vitamin D 605
ACS 583
ACS 581
arginine 574
retinoic acid 573
bromide 571
TNF 557
cysteine 555
hydrogen 535
methionine 534
ethanol 525
zinc 496
anthracene 483
iodine 461
threonine 448
Estradiol 441
5-FU 440
Paclitaxel 439
Luminal 428
MEK 425
Progesterone 413
copper 399
galactose 368
GSH 341
GSH 341
nitric oxide 336
cAMP 333
nitrogen 314
DBA 305
silver 296
alanine 290
MAP 288
CTX 285
Insulin 278
leucine 273
Docetaxel 253
Raloxifene 248
CAM 248
His 242
DFS 237
hyaluronic acid 231
Curcumin 229
ADP 222
salt 220
phenol 219
selenium 218
methanol 217
glutamine 217
Asp 215
ADP-ribose 215
creatinine 213
more...