Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.08 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
estrogen receptor 11340
Sep 9613
Mol 8817
HER2 7340
p53 5022
BRCA1 4465
progesterone receptor 4298
epidermal growth factor receptor 4171
aromatase 3301
hormone receptor 2709
BRCA2 2591
nodal 2280
AKT 1715
Bcl-2 1639
PI3K 1579
neu 1547
erbB-2 1507
caspase-3 1495
E-cadherin 1479
oestrogen receptor 1389
mTOR 1380
EGFR 1353
cyclin D1 1353
cytokine 1338
insulin 1324
tyrosine kinase 1315
p21 1277
Ki-67 1265
MRI 1199
MAPK 1182
epidermal growth factor 1138
vascular endothelial growth factor 1123
She 1097
ERK 1038
PARP 1035
CD44 1028
collagen 1019
histone 984
NMR 982
catenin 905
estrogen receptor alpha 840
ERK1 834
cage 805
PTEN 793
ATP 756
prolactin 740
VEGF 725
androgen receptor 710
p38 700
EGF 690
matrix metalloproteinase 672
P-glycoprotein 671
TNM 665
Aromatase 661
Estrogen receptor 643
vimentin 637
STAT3 627
CD24 625
ERBB2 609
proteasome 597
glycoprotein 595
insulin-like growth factor 585
pS2 585
IL-6 582
ACS 581
CD8 580
receptor tyrosine kinase 575
p27 574
MMP-9 570
TNF 557
CDK4 546
PIK3CA 545
fibronectin 516
ubiquitin 514
UTR 504
endoplasmic reticulum 501
ESR1 493
tumor necrosis factor 484
urokinase-type plasminogen activator 479
caspase-9 478
tumour suppressor 476
ROS 470
PEG 465
annexin V 454
cyclin 451
EGF receptor 450
c-myc 449
ATM 446
c-Myc 444
cathepsin D 441
chemokine 441
MEK 440
proto-oncogene 436
JNK 436
histone deacetylase 435
CD4 432
MMP-2 419
cyclin E 414
phosphatidylinositol 3-kinase 412
cytokeratin 411
proliferating cell nuclear antigen 405
CEA 404
nuclear receptor 400
EMT 398
survivin 395
phosphatase 395
leptin 393
interferon 391
FDG 387
CXCR4 386
cytochrome c 384
caspase-8 381
IGF-I 379
IFN 377
carcinoembryonic antigen 374
MUC1 373
albumin 368
mucin 368
polypeptide 366
cytochrome P450 361
fused 359
osteosarcoma 358
MYC 357
IL-8 355
Rho 351
p65 350
alkaline phosphatase 341
ADR 340
neuregulin 338
bcl-2 330
kit 329
Pol 322
cancer susceptibility 322
lymphoid 320
extracellular signal-regulated kinase 318
Cyclin D1 318
mutant p53 314
cyclooxygenase-2 310
c-Jun 304
GSH 303
N-cadherin 302
CXCL12 301
serum albumin 300
non-Hodgkin's lymphoma 299
PD-L1 297
COX-2 293
cyclin-dependent kinase 293
TGF-beta 292
AP-1 290
Sp1 288
MMP9 287
San 280
PC-3 277
poly(ADP-ribose) polymerase 275
granulocyte colony-stimulating factor 273
beta-catenin 267
CDH1 265
histone H3 262
interleukin-6 262
phosphoinositide 3-kinase 261
more...
Disease
breast cancer 160383
cancer 73177
tumor 44093
MCF 15455
metastases 10569
carcinoma 9634
tumor growth 5661
tumorigenesis 4758
metastatic breast cancer 4590
tumor progression 4330
carcinogenesis 4139
lung cancer 3608
ovarian cancer 3583
prostate cancer 3352
melanoma 2756
primary tumor 2504
colorectal cancer 2105
ductal carcinoma in situ 1948
adenocarcinoma 1850
ductal carcinoma 1777
colon cancer 1773
mammary tumor 1767
obesity 1765
leukemia 1726
bone metastases 1475
endometrial cancer 1421
cervical cancer 1372
gastric cancer 1363
osteoporosis 1276
aggressiveness 1170
hepatocellular carcinoma 1152
diabetes 1082
lymphoma 1017
depression 1014
carcinoma of the breast 941
pancreatic cancer 855
lymphedema 850
non-small cell lung cancer 821
neutropenia 818
cardiovascular disease 783
uterus 769
brain metastases 702
multiple myeloma 694
Hodgkin's disease 656
liver cancer 634
invasive cancer 621
ATM 581
squamous cell carcinoma 571
hypertension 562
lung metastases 532
renal cell carcinoma 520
tumor angiogenesis 505
liver cancer 501
anemia 496
glioblastoma 492
sarcoma 483
carcinoma of the breast 473
recurrent breast cancer 464
bladder cancer 458
solid tumor 444
retinoblastoma 443
glioma 437
inflammatory breast cancer 435
residual disease 428
Luminal 424
stroke 420
liver metastases 414
epithelial ovarian cancer 406
infiltrating ductal carcinoma 405
lung carcinoma 399
EMT 398
osteosarcoma 388
myelosuppression 386
thrombocytopenia 379
tumor initiation 369
acute myeloid leukemia 367
thyroid cancer 358
SCID 358
renal cancer 352
neuroblastoma 348
non-Hodgkin's lymphoma 342
hypercalcemia 342
carcinoma in situ 328
leukopenia 328
skin cancer 324
aggression 319
cancer recurrence 309
GSH 303
type 2 diabetes 302
bilateral breast cancer 295
coronary heart disease 293
B-cell lymphoma 286
West 285
HIV 284
heart disease 280
head and neck cancer 278
infertility 272
bone disease 265
Steroids 263
Alzheimer's disease 262
Fanconi 259
esophageal cancer 258
psychological distress 257
abortion 250
heart failure 248
lobular carcinoma in situ 237
esophageal cancer 236
BLM 235
systemic disease 234
cognitive impairment 231
small cell lung cancer 230
neoplastic transformation 229
pneumonia 224
coronary artery disease 223
congestive heart failure 222
amenorrhea 209
cystic fibrosis 208
cold 205
myocardial infarction 203
TAM 202
DM1 202
endometriosis 200
SDS 198
Blocking 198
uterine cancer 193
peripheral neuropathy 191
SEM 183
metabolic syndrome 183
neuropathy 181
rectal cancer 180
stomatitis 178
lymphadenopathy 175
NOD 175
testicular cancer 175
atherosclerosis 173
emotional distress 171
carcinomatosis 170
chronic myeloid leukemia 169
Poland 168
adenoma 168
rheumatoid arthritis 168
Li-Fraumeni syndrome 165
APC 165
fibrocystic disease 164
mastopathy 163
infectious diseases 163
rash 163
hematologic malignancies 162
brain tumor 161
rare disease 161
AIDS 160
PDB 158
hepatoblastoma 158
Breast carcinoma 158
tumor vasculature 155
TEM 153
chronic disease 152
DDP 152
lymphatic vessels 151
dysplasia 151
more...
Symptom
pain 1757
fatigue 837
nausea 644
overweight 482
vomiting 479
menopausal symptoms 409
diarrhea 400
nausea and vomiting 324
anesthesia 324
bone pain 278
hot flashes 277
hot flushes 277
discomfort 235
headache 200
nipple discharge 199
dyspnea 199
nipple discharge 188
starvation 187
discomfort 180
weakness 167
erythema 153
anorexia 151
arthralgia 141
insomnia 113
collapse 97
constipation 93
myalgia 92
abdominal pain 91
cough 85
analgesia 83
numbness 82
cachexia 81
asthenia 76
back pain 71
mastalgia 65
paresthesia 65
ataxia 56
cancer pain 53
stigma 53
seizures 52
sleepiness 51
exhaustion 51
night sweats 49
chills 48
dizziness 48
Ill 47
chest pain 46
HSA 42
shortness of breath 36
acidity 34
hopelessness 33
angina 31
flushing 30
peri-menopausal 28
thinning 27
lethargy 27
low back pain 27
vertigo 23
myoclonus 22
masculinization 20
memory loss 20
breast hyperplasia 20
irregular bleeding 19
shoulder pain 19
respiratory distress 18
cerebellar ataxia 18
tremor 17
acute pain 17
splenomegaly 17
Depressive symptoms 17
agitation 16
peau d'orange 16
epigastric pain 16
neck pain 16
Scratch 16
Breast pain 15
syncope 15
distraction 15
decreased appetite 14
arm pain 14
hepatomegaly 14
dysarthria 14
muscle stiffness 13
hemoptysis 12
ENT 12
bloating 11
abdominal discomfort 11
pelvic pain 11
hypothermia 11
leg cramps 11
forgetfulness 11
physical symptom 10
tinnitus 10
blurred vision 10
exertional dyspnea 10
dry skin 10
muscle cramps 9
apathy 9
physical appearance 9
neuralgia 9
paresis 9
polyuria 9
hoarseness 9
dysesthesia 9
dysuria 9
functional recovery 8
acute stress 8
tingling 8
mental fatigue 8
alexithymia 8
leg edema 8
paraparesis 8
skin irritation 8
Musculoskeletal symptoms 7
ophthalmoplegia 7
Vaginal dryness 7
Postoperative pain 7
Cancer Fatigue 7
muscle rigidity 6
abdominal fullness 6
hip pain 6
tachypnea 6
hunger 6
spasm 6
persistent cough 6
Neuropathic pain 5
CSR 5
axillary pain 5
dry eye 5
chorea 5
polydipsia 5
fever of unknown origin 5
flank pain 5
Mills 5
heartburn 5
tenesmus 5
hyperesthesia 5
Decreased activity 5
general problem 5
Signs and Symptoms 5
leg pain 5
sore throat 5
skin damage 5
acute abdomen 4
urinary frequency 4
Welt 4
oliguria 4
lightheadedness 4
limb pain 4
No adverse effect 4
chronic back pain 4
tense 4
eye pain 4
cyanosis 4
hepatosplenomegaly 4
stomach pain 4
Fluctuation 4
tonic-clonic seizure 4
bitter taste 4
dystonia 4
more...
Drug
Herceptin 1323
ICI 608
MAP 540
lysine 532
ROS 470
Adriamycin 401
Taxol 393
EE2 369
Estrogens 353
ADR 340
Docetaxel 335
CSF 304
CTX 285
ROC 263
Raloxifene 248
G-CSF 244
vitamin E 238
Fulvestrant 234
DM1 199
IL-2 197
Dermatol 193
uPA 171
IFN-gamma 165
Monit 160
ascorbate 140
CTX 133
Paraffin 130
ADM 128
Taxotere 127
Zoledronic acid 126
Cardiovasc 126
Mutagen 119
GEO 119
ABC 118
Bevacizumab 118
Arimidex 116
Gel 116
Zoledronic acid 101
NADH 100
caffeine 95
Vinorelbine 94
Gefitinib 91
Pertuzumab 76
Everolimus 72
Retinoic acid 71
CTX 67
ETS 66
Leaf 61
Zoladex 60
TAT 60
CAM 59
Asn 57
Denosumab 56
TAC 56
MRC 54
Norplant 53
CTC 52
CTC 51
Zoladex 50
Femara 50
NVP 49
Vitamin E 49
Ixabepilone 49
Glutathione 48
ZnO 47
Albumin 47
Tibolone 44
Spectrum 43
Cetuximab 43
ENT 43
Fluorescein 43
Depo-Provera 40
Cremophor EL 38
Bortezomib 38
citric acid 37
PTH 36
DNase I 36
Alliance 34
Imatinib 34
Etoposide 33
Navelbine 33
Erlotinib 33
BLM 33
CPT-11 32
EPI 32
Indomethacin 32
Dasatinib 32
Xeloda 31
Sorafenib 31
Gelatin 31
HCG 31
MDS 31
G418 31
Norplant 30
EPA 30
Simvastatin 30
CCL 30
DHT 29
Arsenic trioxide 29
p75 29
DHT 29
Gleevec 29
Pemetrexed 29
lactose 28
Filgrastim 28
Glycyrrhiza 28
THF 28
PCB 28
Vitamin A 27
Novantrone 27
Rituximab 27
IL-11 27
RAL 26
TTC 26
Ethanol 26
Evista 25
Filgrastim 25
Tykerb 25
niacin 24
Gemzar 24
Fraction 24
APD 24
4-Hydroxytamoxifen 23
ALA 23
Luteinizing 23
Indocyanine green 22
Doxycycline 22
Fluorescein 22
Ibandronate 21
Idarubicin 21
RFP 20
Activin 20
Vorinostat 20
Growth hormone 19
VCR 19
Epidoxorubicin 19
HCH 19
Leucovorin 19
Award 18
-deoxyadenosine 18
DMAP 18
Angiotensin II 18
Itraconazole 18
Irinotecan 18
Portal 18
Levonorgestrel 18
FAD 18
Clodronate 17
2-Methoxyestradiol 17
Fragment 17
Aromasin 17
Lovastatin 17
Emodin 17
Biopolymers 17
Bexarotene 17
Emodin 17
ACT 17
Flavopiridol 16
MOF 16
Premarin 16
more...
Enzyme
ERK 10031
mitogen-activated protein kinase 3003
luciferase 1470
focal adhesion kinase 1457
protein kinase 1289
caspase-3 1126
PARP 1122
P-glycoprotein 677
proteasome 606
MEK 600
ACS 581
urokinase-type plasminogen activator 562
protein kinase C 484
cdc2 424
reverse transcriptase 418
phosphatidylinositol 3-kinase 412
caspase-9 387
cathepsin D 385
topoisomerase 374
topoisomerase 355
glutathione S-transferase 354
alkaline phosphatase 341
catalase 304
peroxidase 302
caspase-8 298
ATPase 292
AMP-activated protein kinase 283
phosphoinositide 3-kinase 261
RNA polymerase 259
superoxide dismutase 232
lactate dehydrogenase 208
AMPK 202
trypsin 193
collagenase 187
APC 179
DNA methyltransferase 174
AMPK 173
GSK 170
sulfatase 161
MMP 156
aldehyde dehydrogenase 152
aldehyde dehydrogenase 151
aldehyde dehydrogenase 148
aldehyde dehydrogenase 148
aldehyde dehydrogenase 148
RNase 143
calcineurin 140
glutathione peroxidase 137
RNase 137
thymidylate synthase 128
NQO1 126
MDR 125
thymidine kinase 123
alanine aminotransferase 120
IKK 120
prostate-specific antigen 119
thrombin 115
cathepsin B 110
CYP3A4 108
aspartate aminotransferase 108
caspase-7 105
MAP 105
caspase-7 105
demethylase 98
DNA polymerase 97
ALDH 93
matrix metalloproteinase 9 92
glyceraldehyde-3-phosphate dehydrogenase 91
phospholipase C 89
ornithine decarboxylase 86
NOS 85
plasmin 84
dihydrofolate reductase 82
thymidine phosphorylase 76
PDK1 75
transcriptase 75
beta-galactosidase 74
matrix metalloproteinase 2 72
tissue plasminogen activator 71
hyaluronidase 68
firefly luciferase 66
hyaluronidase 64
lysyl oxidase 63
chloramphenicol acetyltransferase 62
TAT 61
histone demethylase 60
endonuclease 60
HSD 60
methylenetetrahydrofolate reductase 59
methylenetetrahydrofolate reductase 58
protein phosphatase 2A 58
STK11 57
CD10 56
MMP-3 56
kinesin 56
histone acetyltransferase 53
carbonic anhydrase 52
phosphodiesterase 52
neuraminidase 51
dihydropyrimidine dehydrogenase 51
adenylate cyclase 51
hexokinase 51
polo-like kinase 1 50
ribonuclease 50
complex I 50
thioredoxin reductase 50
ribonuclease 50
estrogen sulfotransferase 49
PRA 49
alcohol dehydrogenase 49
DNase 49
renin 49
arylsulfatase 48
kallikrein 47
granzyme B 46
gamma-glutamyl transpeptidase 46
glutathione reductase 45
dihydropyrimidine dehydrogenase 45
AST 45
glutaminase 44
glucose-6-phosphate dehydrogenase 43
sialyltransferase 43
sialyltransferase 42
caspase-1 42
sialyltransferase 42
acid phosphatase 41
pyruvate kinase 41
NADPH oxidase 41
NADPH oxidase 40
glyceraldehyde-3-phosphate dehydrogenase 40
MDP 40
estrogen sulfotransferase 40
ribonucleotide reductase 40
CAD 40
lipoxygenase 40
creatine kinase 40
CAD 40
CAD 40
cathepsin K 39
phospholipase A2 39
CPT 39
lipase 39
phospholipase D 38
ACE 37
CPT 36
acetylcholinesterase 36
CPT 36
ribonucleotide reductase 35
ADH 35
glyceraldehyde-3-phosphate dehydrogenase 35
chymotrypsin 35
cytosine deaminase 35
cathepsin L 34
TOR 34
glyceraldehyde-3-phosphate dehydrogenase 34
glyceraldehyde-3-phosphate dehydrogenase 34
MEKK1 33
UDP-glucuronosyltransferase 33
MIP 32
ATP synthase 32
more...
Compound
DNA 12556
MDA 11788
Dec 10690
Clin 9775
oxygen 2227
Tamoxifen 2083
MTT 2039
Tamoxifen 2027
tyrosine 1528
water 1424
calcium 1390
Estrogen 1363
Estrogen 1360
acetate 1189
glucose 1188
Pac 895
PEG 871
Adriamycin 820
ADR 791
ATP 759
serine 743
lysine 697
phosphate 692
sulfate 683
sodium 664
TNM 663
iron 615
PEG 611
ICI 610
vitamin D 605
ACS 583
ACS 581
arginine 574
retinoic acid 573
bromide 571
TNF 557
cysteine 555
hydrogen 535
methionine 534
ethanol 525
zinc 496
anthracene 483
iodine 461
threonine 448
Estradiol 441
5-FU 440
Paclitaxel 439
Luminal 428
MEK 425
Progesterone 413
copper 399
galactose 368
GSH 341
GSH 341
nitric oxide 336
cAMP 333
nitrogen 314
DBA 305
silver 296
alanine 290
MAP 288
CTX 285
Insulin 278
leucine 273
Docetaxel 253
Raloxifene 248
CAM 248
His 242
DFS 237
hyaluronic acid 231
Curcumin 229
ADP 222
salt 220
phenol 219
selenium 218
methanol 217
glutamine 217
Asp 215
ADP-ribose 215
creatinine 213
proline 208
SDS 204
TOF 199
TEM 198
CAP 194
NH2 192
ADP 187
ADP 185
AMP 184
NAD 181
urea 180
pyridine 176
Phe 174
tryptophan 173
ASA 172
pyrene 171
pyrimidine 171
DDP 168
pyrimidine 168
potassium 165
Metformin 162
Metformin 161
Melatonin 159
Vimentin 155
GTP 155
glutamate 151
N-acetylcysteine 150
Anastrozole 149
fluorine 149
Gly 149
formaldehyde 148
NAD 144
Resveratrol 144
ethyl acetate 143
DHA 142
boron 141
Optimal 139
Methotrexate 138
Letrozole 136
Vitamin D 135
NADPH 135
NADPH 135
silicon 133
MTS 133
acridine 133
cadmium 133
Exemestane 131
Genistein 127
tryptophan 126
MDR 126
DMSO 125
H2O2 125
Capecitabine 124
Ile 121
tryptophan 119
tryptophan 119
TPA 116
TPA 114
ammonium 112
THP 111
DPPH 111
retinol 111
aldehyde 111
THP 108
PMA 105
IDC 105
indole-3-carbinol 104
Histone 104
Gemcitabine 102
Gemcitabine 102
Epirubicin 101
CAT 101
MPA 101
MPA 100
NADH 100
MPA 100
PGA 99
CAT 99
CAT 99
DTPA 98
more...