Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0006142 (
breast cancer
)
160,383
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Genome-wide sequencing studies in
breast cancer
have recently identified frequent mutations in the
zinc finger protein 668
(
ZNF668
), the function of which is undefined. Here, we report that
ZNF668
is a nucleolar protein that physically interacts with and regulates p53 and its negative regulator MDM2. Through MDM2 binding,
ZNF668
regulated autoubiquitination of MDM2 and its ability to mediate p53 ubiquitination and degradation.
ZNF668
deficiency also impaired DNA damage-induced stabilization of p53. RNA interference-mediated knockdown of
ZNF668
was sufficient to transform normal mammary epithelial cells.
ZNF668
effectively suppressed
breast cancer
cell proliferation in vitro and tumorigenicity in vivo. Taken together, our studies identify
ZNF668
as a novel breast tumor suppressor gene that functions in regulating p53 stability.
...
PMID:ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. 2185 83
