Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1060 Japanese patients, 58 and 36% of breast tumors contained estrogen (ER) and progesterone receptors (PR), respectively. These rates are somewhat lower than those in Western countries. The slightly lower incidence of receptors in Japanese patients is due to significantly lower incidence of receptor positive tumors in postmenopausal Japanese patients than in postmenopausal Western patients. However, in postmenopausal overweight (greater than or equal to 60 kg) Japanese patients the rate of ER + breast cancer was comparable to that in postmenopausal Western patients. The effect of overweight on an increased incidence of Japanese breast cancer was found to be confined to postmenopausal women. In 260 Japanese breast cancer patients, the regression rates to endocrine therapy were 10% for ER-tumors, 48% for ER + tumors, and 66% for ER +, PR + tumors, which are similar to those reported in Western countries.
 ...
PMID:International comparisons concerning breast cancer and steroid receptors. 375 42

Mortality ratios by relative weight categories compared to average weights were computed for 750,000 men and women. Data came from the American Cancer Society's prospective study, conducted in 1960-1972. Males who were 40% or more overweight had a mortality ratio of 1.87 for all causes of death. The ratio in women was 1.89. High mortality ratios were also observed in overweight men and women who died of coronary heart disease, diabetes and digestive diseases. The mortality ratio for cancer in obese men was 1.33; 1.55 for obese women. Sites with high mortality ratios in obese males were colon-rectum and prostate; in women, endometrium (about 5 times as high as for average weights); cervix (2 times as high), gall bladder (3.5 times), ovary (mortality ratio of 1.6) and breast cancer (mortality ratio of 1.5).
 ...
PMID:Overweight and mortality. 375 7

To determine if body weight and serum cholesterol are associated with advanced primary breast cancer, the authors compared levels of both by TNM stage and estrogen receptor protein (ERP) concentration in a population of 148 premenopausal and 167 postmenopausal white women with histologically confirmed Stage I, II, and IIIa breast cancer. The women were admitted to Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City between 1982 and 1984. Overweight, whether measured as body weight in pounds, Quetelet index, or body surface area, was not found to be associated with TNM tumor stage, tumor size, extent of axillary node disease, or ERP concentration at mastectomy. Elevated serum cholesterol, either alone or in combination with overweight, also showed no association. When assessed in light of earlier studies, the study findings suggest that if overweight, as defined in this study, and/or elevated serum cholesterol do influence early breast cancer recurrence, they do so other than through an association with advanced primary disease. Suggestions for future research are proposed.
 ...
PMID:Body weight, serum cholesterol, and stage of primary breast cancer. 376 33

This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast cancer patients and control patients. Normal-weight controls had significantly lower %NPBE compared with overweight controls and normal-weight and overweight breast cancer patients. There was a significant shift in the percent distribution of estradiol from SHBG to albumin in breast cancer patients, independent of body weight. Elevated %NPBE and abnormal percent estradiol distribution on albumin persisted after mastectomy and were unrelated to menopausal status, presence and stage of disease, and tumor estrogen receptor levels. These results show that breast cancer patients have increased exposure to unbound circulating estradiol and an increased percentage of estradiol bound to albumin, which may influence the availability of estradiol, considering its low binding affinity to albumin. Because these abnormalities persist after mastectomy, the current results may be important in developing dietary intervention protocols that correct %NPBE and abnormal estradiol distribution on binding proteins.
 ...
PMID:Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients. 394 90

Numerous epidemiologic studies have found body size to be a significant risk factor in the etiology of breast cancer. In an Israeli study population of 1,065 breast cancer patients, 964 surgical controls, and 981 neighborhood controls, height and weight at three periods (age 18, "most of adult life," and recent) were ascertained. The authors analyzed these parameters and body mass index (weight/height) for each period, as well as body mass index changes throughout life, controlling for age, menstrual status, and ethnic origin. Odds ratios were determined for three body mass index categories: 19.1-23, 23.1-27, and 27.1+, with a relative risk of 1 for body mass index less than or equal to 19. Their results show an increase in risk for breast cancer with greater recent body mass index among postmenopausal women aged 60+ (n = 461 for breast cancer, n = 414 for surgical controls, n = 401 for neighborhood controls). Crude odds ratios for the breast cancer/surgical control comparison are 1.23, 1.58, and 2.20, respectively, for each body mass index category; for the breast cancer/neighborhood control comparison 2.16, 2.44, and 2.99, respectively. Odds ratios adjusted for confounding factors (ages at menarche, first birth, and menopause; number of births; years of education; previous benign breast disease; and family history of breast cancer) are 1.17, 1.44, and 2.38, respectively (breast cancer/surgical control); and 1.78, 1.92, and 2.53, respectively (breast cancer/neighborhood control). Overweight does not emerge as a risk factor for breast cancer among premenopausal or younger postmenopausal women. Weight loss from most of adult life to recent weight appears to be protective, since mean loss in the 60+ age category is greater in both control groups than in breast cancer patients. In addition, breast cancer patients aged 60+ gained more weight during adult life than controls, and premenopausal breast cancer patients gained less weight than controls (for both comparisons, p less than or equal to 0.05, breast cancer vs. all controls combined.
 ...
PMID:Overweight and changes in weight throughout adult life in breast cancer etiology. A case-control study. 402 1

In a prospective study, mortality ratios were computed in relation to overweight, cancer, and other diseases. The study included 750 000 men and women followed for 12 years. Each person was given a weight index. Death rates for overweight and underweight persons were compared with rates for persons of average weight. Men who were 40% or more overweight had a mortality ratio for cancer of 1.33; women, 1.55. This ratio was much lower than that for coronary heart disease (men, 1.95; and women, 2.07); diabetes (5.19 and 7.90), and digestive diseases (3.99 and 2.29). Overweight men had significantly higher mortality ratios for colorectal and prostate cancer; overweight women had much higher rates for cancer of the endometrium, gall bladder, and cervix; and also significantly higher rates for ovary and breast cancer.
 ...
PMID:Overweight and cancer. 406 20

Subcutaneous adipose tissue was examined in 77 patients with breast cancer, 61 patients with lung cancer and in a control group of 23 male and 27 female with non-tumor pathology; the weight and age of controls matched those of cancer patients. The obesity in breast cancer patients was of the hypertrophic type, and of combined type (hypertrophic-hyperplastic) in patients who were more than 50% overweight. The increased level of adipose tissue in lung cancer patients was mostly due to the larger size of adipocytes. The concentration of unsaturated fatty acids in adipose tissue in breast cancer patients was in direct correlation with the level of this tissue and adipocyte size, while, in lung cancer group, this correlation was reversed. There was no inverse correlation between the size and c-AMP level of adipocytes in both cancer groups. Resistance to the inhibitory effect of glucose on lipolysis occurring in adipose tissue was more frequent in cancer patients than in controls. Antilipolytic effect of insulin in subcutaneous adipose tissue of breast cancer patients was less pronounced than in lung cancer group. Liposynthetic activity in adipose tissue was identical in all study groups. Lipolytic activity in adipose tissue was enhanced in both cancer groups, but in the breast cancer group it was in direct correlation with overweight, while in lung cancer patients--with the degree of tumor progression.
 ...
PMID:[Morphometric and biochemical peculiarities of fatty tissue in patients with cancer of the breast and lung]. 630 31

Breast cancer among Japanese females was characterized by a relatively low incidence and good prognosis. But recently its morbidity is increasing and its biological behavior is changing. The chronological changes and prospective features of breast cancer among Japanese females are follows: 1. Increase of morbidity and mortality 2. Increase of the ratio of poorly differentiated carcinoma and decrease of well differentiated carcinoma 3. Increase of the incidence of lobular carcinoma 4. Increase of the case of the aged females Above items show that breast cancer among Japanese females is becoming westernizing. The case-control study on "breast cancer occurrence and obesity" shows that an obesity of the aged is a significant high risk factor for breast cancer occurrence. There fore, it would be effective that the prevention of overweight at the postmenopausal women to reduce the breast cancer occurrence. The chronological rise of overall 10-year survival rate of operated breast cancer is caused by increasing the ratio of early stage cases. Suggesting an importance of regular self-examination of the breast. Furthermore, it is important to establish an adjuvant therapy without causing side effect for curatively operated cases. Concerning the cancer of the uterus among Japanese females, the chronological occurrence rate of endometrial cancer is increasing, while the death rate of cervical cancer is decreasing.
 ...
PMID:[Breast cancer in Japan--past trend and future prospect]. 671 67

In Japan, the incidence of breast cancer is remarkably lower than in Western countries. We examined tumor estrogen (ER) and progesterone receptors (PgR) in 1060 Japanese breast cancer patients. In Japan, 58% and 36% of breast cancers revealed measurable amounts of cytosol ER and PgR, respectively. These rates are slightly lower than those reported in Western countries, which were found to be 60-80% and 40-60%, respectively, though the difference is mainly confined to postmenopausal non-overweight (less than 60 kg) patients. The objective remission rates to endocrine therapy were 48% for ER+ tumors, 10% for ER-tumors, 66% for ER+, PgR+ tumors, 30% for ER+, PgR- tumors and 10% for ER-, PgR- tumors. These response rates are similar to those in Western breast cancer patients. ER and/or PgR in the breast cancer cytosol are useful markers for predicting response to endocrine therapy. The present findings also indicate that ER- tumors are estrogen independent but ER+ tumors include both estrogen-dependent and -independent tumors and that some of ER+ but endocrine-resistant tumors have postreceptor defect. The presence of ER+ but endocrine-resistant tumors may be due in part to the loss of hormone-dependency of estrogen-dependent breast cancer during endocrine therapy. The transformation of hormone-dependent mouse tumor cells into independent tumor cells was demonstrated as one of the mechanisms involved in the loss of hormone-dependency.
 ...
PMID:Hormone receptors and Japanese breast cancer. 676 94

In recent years, the concept of nutritional support as a part of a comprehensive cancer management program has gained increasing acceptability. However, little data is available in regard to the effect of nutritional support programs on the chronic disease state represented by recurrent or persistent cancer that characterizes patients undergoing systemic chemotherapy. In 1977 we undertook to study this problem in a randomized prospective study designed to evaluate the effects of long-term (12 months) enteral nutritional support in a group of ambulatory breast cancer patients undergoing a standard cytotoxic chemotherapy treatment program, in an adjuvant or therapeutic setting. The results of this study suggest that patients with breast cancer are overweight as compared to the general population and that any significant change in initial body weight, either a gain or a loss, is associated with an increased risk of recurrent disease. Data are presented which show little or no correlation between standard parameters of nutritional assessment and risk of disease recurrence and/or response to chemotherapy. These data also suggest that until we better understand the relationship between tumor and host in breast cancer patients, we offer nutritional support programs only in situations where there are specific clinical indications for such interventions.
 ...
PMID:Long-term nutritional support as an adjunct to chemotherapy for breast cancer. 679 11


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>