Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum levels of circulating immune complexes (CIC) in 13 patients with breast cancer, 12 patients with uterine cervix cancer, 4 patients with uterine corpus cancer, 11 patients with lung cancer and 15 healthy persons were estimated by means of the PEGIKEM test during one day at 6 a. m., 11 a. m. and 5 p. m. Maximal deviations from the highest daily levels were expressed in percentage of them. These deviations range on average between 18-26 percent and are not significantly different from those of healthy persons (29 percent). Fluctuation of CIC levels in various patients differs in an individual manner. There is not the same tendency of changes of CIC level within two consecutive days, either. To interpret right a single value of CIC level one must be aware of its possible fluctuation.
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PMID:The fluctuation of circulating immune complexes level in patients with malignancy. 647 21

Relative incidences of esophagus, lung and breast cancers differ in the various populations in Kyrgyzstan. Esophagus cancer is the most commonly observed among the Turkic groups, especially in Kazakhs, while lung and breast cancer are frequently encountered among the European representatives of the population - Russians in particular. Fluctuation in rates for these cancer forms in the Kyrgyzstan mountain regions is highly dependable on the height above sea level. One potential major factor, which may account for the low cancer frequency in general and influence esophagus, lung and breast cancer forms in particular - is mountain hypoxia. Since, among the native citizens (Kyrgyzes), which are adapted to mountain hypoxia conditions (population adaptation), the indicated cancer forms are not so often than the same forms appearance among the other ethnical groups (long adaptation), especially newcoming ones. Thus, the incidence rates of esophageal cancer in the Kazakh population is about 32,3 (per 100,000), the same sickness in Kyrgyz is about 11,3, the figure for lung cancer among the Russian population is 34,8, while among Kyrgyzes it is 11,2, breast cancer incidence in Russian citizens is 34,8 but only15,1 among Kyrgyz residents. It could be established that the studied forms of cancer are less common in high mountain regions than in the regions with low mountains. To a certain extent, mountain hypoxia may function like a brake for the development of cancer tumors. HGowever, the situation is complex, because of, the presence of the other factors entailed by the demographic, social-economic and other variation.
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PMID:Epidemiology of Esophagus, Lung and Breast Cancer in Mountainous Regions of Kyrgyz Republic. 1271 12

The immunohistochemical (IHC) biomarkers of breast cancer, especially hormone receptors and HER2, are very important because the pharmacological therapeutic strategy is generally decided by biomarker expression patterns. Biomarkers are examined on pre-chemotherapeutic biopsy materials from patients in whom neoadjuvant chemotherapy is planned. Statistically significant changes between pre- and post-chemotherapeutic markers have been reported; however, the alterations in biomarkers are poorly understood. Fluctuation of the Ki-67 labeling index (LI) between pre- and post-neoadjuvant therapy is associated with chemotherapeutic effects and with the prognosis of patients. It has been shown that IHC evaluation of Ki-67 LI is useful as a predictive and a prognostic factor. There are issues to be considered surrounding the use of the IHC Ki-67 LI in routine practice, including the standardization of staining procedures and a cutoff point for Ki-67 LI detection. The current understanding of IHC evaluation of biomarkers for breast cancer under neoadjuvant chemotherapy is reviewed based on the literature.
Breast Cancer 2011 Apr
PMID:Alteration of immunohistochemical biomarkers between pre- and post-chemotherapy: hormone receptors, HER2 and Ki-67. 2129 Feb 65

The aim of our present study was to elucidate the effects of up-regulation and down-regulation of intracellular reactive oxygen species (ROS) level on proliferation, migration, and related molecular mechanism. Breast cancer cells were treated by catalase or H2O2. MTT, colony formation assay, and Hoechst/PI staining were used to evaluate proliferation and apoptosis. The level of intracellular ROS was measured by dichlorodihydrofluorescein diacetate probes. The ability of migration was detected by wound healing. Western blotting and coimmunoprecipitation (co-IP) were used to determine the expression of DLC1 and CAV-1 and their interaction. Our data indicated that up-regulation of intracellular ROS induced by H2O2 significantly inhibited proliferation and induced apoptosis accompanying G1 cell cycle arrest and elevated expression of p53. For cell migration, either up-regulation or down-regulation of ROS induced migration inhibition with reduction of interaction between DLC1 and CAV-1. Our results suggested that up-regulation of intracellular ROS inhibited proliferation by promoting expression of p53 and induced G1 cycle arrest and apoptosis. Fluctuation of ROS inhibited migration through reducing the interaction between DLC1 and CAV-1.
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PMID:Fluctuation of ROS regulates proliferation and mediates inhibition of migration by reducing the interaction between DLC1 and CAV-1 in breast cancer cells. 2813 Jul 53