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Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the interests of uniformly high radiological physics standards at ACS-NCI Breast Cancer Detection Demonstration Projects, measurements were made at 29 breast cancer screening clinics. These measurements were made throughout the country with equipment calibrated with standards traceable to National Bureau of Standards. Histograms which indicate the frequency distribution of exposures to the surface of a 6 cm breast for various machine/receptor combinations were prepared.
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PMID:Interim report: mammographic exposures at the breast cancer detection demonstration project screening centers. 18 50

Radical mastectomy as originally conceived at the turn of the century consisted of complete removal of the breast tissue, the overlying skin, the pectoral muscles, the intervening lymphatics and the axillary lymph nodes. The aim was logical but initially the results were poor. Only 41% of the 76 patients in Halsted's original series were without disease at the end of 3 years. The principal reason for this was the advanced stage of disease in the patients selected for treatment. By contrast, Gilbertsen, using clinical examination alone, surveyed women 45 years of age or older and found that of 32 patients with breast cancers detected by the screening procedure, 24 had no axillary lymph node involvement. The absolute 5-year survival rate of this group was 96%, which approaches the anticipated survival of comparable women free of breast cancer. Those with positive lymph nodes had an absolute survival rate of 75% at 5 years. Further, of 13 patients observed for 10 years, the survival rate for those without node involvement was 90% and for patients with node involvement was 33%. Patients treated at the Barnes Hospital in St. Louis between 1912 and 1933 were contrasted with similarly treated patients at the Barnes Hospital and the Ellis Fischel Cancer Hospital from 1940 to 1955. A poorer survival rate in the earlier series was related primarily to the greater frequency of advanced and larger tumors. That a significant reduction in breast cancer mortality can be achieved is becoming increasingly apparent. Among survey-detected breast cancers in the study conducted by the Health Insurance Plan of Greater New York, the 6-year mortality was half of that of controls. This reduction is even more impressive when one considers that among these patients were many with full invasive, mass-forming carcinomas at the time of initial screening. A recent report by Wanebo, Huvos and Urban discusses the treatment of prognostically favorable forms of breast cancer by modified radical mastectomy. It is possible to select from among their patients those who fit the definition of minimal breast cancer. In this group the 5-year survival rate was 97% and the 10-year survival rate was 95%. Only 1 patient died of breast cancer in 10 years. In another reported group of 65 patients with intraductal carcinoma only, there were no deaths due to breast cancer in 10 years. Should the NCI-ACS demonstration projects show, as now seems probable, that community screening programs can be effective in early breast cnacer detection, it is to be anticipated that widespread public demand for screening facilities will follow. This may present insurmountable logistic and economic problems. The total number of radiologists in the United States is not sufficient to screen annually the total population of women over age 40, or even over age 50. There is great need for the development of criteria for the ready identification of that segment of the population in which most of the cancers would be found...
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PMID:The detection and diagnosis of early, occult and minimal breast cancer. 18 91

Of 1,810 breast cancers detected in the NCI/ACS Breast Cancer Detection Demonstration Projects, 592 were less than 1 cm in diameter and considered minimal; and tissue slides from 506 of them were available for retrospective review by a panel of pathologists. The initial report of this review indicated that in 66 cases the pathologic features of the presented slides were not sufficient for diagnosis of cancer. Subsequent investigation revealed that, through computer error, the slides submitted in 2 of these 66 cases were not from the lesions in question but from blind biopsy of the contralateral breast. Further review by the pathology panel of tissue from 38 of the 64 remaining cases determined that 16 of the remaining lesions were indeed cancers or borderline malignant lesions. This then left 48 cases in doubt. Only biopsy had been performed in 11 of them, and some form of mastectomy in the other 37. The original pathologic opinion had been divided in 30 of these, and the mastectomy had been delayed for 1 day to 7 months after the biopsy. In only 7 of the 48 questionable cases was definitive treatment carried out at the time of biopsy. All in all, these findings reflect sound, responsible surgical judgment.
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PMID:Diagnosis of minimal breast cancers in the BCDDP: the 66 questionable cases. 42 26

The use of screening mammography among women 40 years of age and older in Los Angeles County was assessed through a random digit dial telephone interview. The sample of 802 women represents a large urban population with substantial proportions of blacks, Hispanics, and Asians. The survey obtained information regarding adherence to the ACS/NCI screening mammography guidelines, perceived benefits of early detection and mammography, perceived threat of developing breast cancer, and barriers to utilization. The results showed that 71% of the women had had at least one mammogram, with 49% having received a screening mammogram according to the guidelines for their age. Less than half the respondents knew the screening guidelines for their age, with women ages 40-49 years being less knowledgeable than women greater than or equal to 50 years old (29 vs 58% answering correctly). A logistic regression analysis predicting the likelihood of having obtained a screening mammogram according to the guidelines found the following to be predictive: concern over radiation (negative association), age (negative association), family history, knowledge of guidelines, and cost of a mammogram (negative association). Other demographic factors and beliefs were not significantly related to this dependent variable.
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PMID:Screening mammography rates and barriers to use: a Los Angeles County survey. 186 57

The American Cancer Society--Duval Unit, in June, 1987, helped organize a community demonstration screening project involving all hospitals and institutions with mammography units in the area. A Northeast Florida Cooperative Breast Cancer Screening Group was formed comprised of physicians and administrators from each institution. A total of 1,200 women agreed to participate in the project and each underwent complete screening including education, instruction in self-examination, physical examination by a physician and mammography as indicated according to ACS guidelines. Of the study group, 1,032 women were eligible for mammography at a participating center, and 628 (61%) underwent a mammogram at no cost to them as instructed. Twenty four (4%) had definite abnormalities which led to biopsy and seven (1%) of them had malignant lesions. The medical community organized to provide breast cancer screening and follow-up with low-cost mammography.
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PMID:Breast Cancer Screening Project in Northeast Florida. 229 24

The paper discusses the results of a study of the case histories of 90 cancer patients. 48 of these patients received a course of treatment including physical rehabilitative therapy, dietotherapy, mesenchemotherapy (fractionated doses of ACS Bogomoletz, zymosan, splenin), oxygen and iodine-bromine baths, mineralized water and non-specific medication (vitamins, ext. eleutherococci, methonine, cholenzyme) and psychotherapy. It is suggested that non-specific therapy generally provided at health resort establishments is indicated in radically-operated stomach and breast cancer patients who reveal no signs of recurrence or metastases. Such therapy may contribute to social and occupational rehabilitation of cancer patients.
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PMID:[Experience in rehabilitating cancer patients at sanatoria and health resorts]. 710 34

1. According to ACS and NCl guidelines, women should begin screening mammography with a baseline film between 35 and 39 years of age. She should then maintain routine mammography screening per the guidelines. 2. Twenty-five percent of women diagnosed with breast cancer have known risk factors. 3. Further investigation of the effectiveness of worksite mammography and mobile mammography vans is needed. 4. Occupational health nurses are in an optimal position to increase the level of current mammography usage.
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PMID:Mammography: role of the occupational health nurse. 811 Mar 2

The mucin glycoprotein-detecting assay CA 15-3 is a valuable tool for monitoring the course of disease in breast cancer patients. Assays of CA 15-3 are based on the use of two MAbs to polymorphic epithelial mucin (PEM). We evaluated the technical and clinical performance of the Chiron ACS BR, an automated competitive chemiluminescence assay using a single MAb, B27.29, and compared the assay's results with those of the Centocor CA 15-3 RIA, the Abbott IMx CA 15-3, and the Boehringer Mannheim Enzymun-Test CA 15-3. The study population consisted of 253 healthy women, 66 patients with benign breast disease, 168 breast cancer patients, and 76 patients with other carcinomas. In the technical evaluation, we assessed the precision and linearity on dilution of the ACS BR assay. Cutoff values (upper limits of values seen in healthy subjects) were determined for all four assays. Agreement between the assays was studied by linear regression analysis. The ACS BR assay gave within- and between-assay CVs of 2.2% and 3.9%, respectively. Three samples from healthy women gave discordant values by ACS BR and were not included in the calculations. All four assays exhibit a highly similar pattern when monitoring breast cancer disease; the closest agreement of values was obtained between ACS BR and Centocor CA 15-3. We conclude that the ACS BR assay is a fast and reliable immunoassay for measuring PEM in serum. Although it detects a slightly different epitope on the PEM molecule than is targeted in other assays, for cancer serum samples it agreed better with the original Centocor CA 15-3 assay than did the other two CA 15-3 assays tested.
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PMID:Clinical and technical evaluation of ACS BR serum assay of MUC1 gene-derived glycoprotein in breast cancer, and comparison with CA 15-3 assays. 910 58

Early detection offers women the best chance of finding breast cancer early when it is most treatable. Both the ACS and the NCI now recommend mammography and CBE for women ages 40 and older. These organizations also recommend monthly BSE as a positive health practice. Nurses can play an important role in promoting screening by: (a) teaching women about screening guidelines, the benefits and limitations of screening, and risk factors for breast cancer and (b) helping women to reduce or eliminate barriers to screening.
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PMID:The nurse's role in promoting breast cancer screening. 940 Feb 17

An increase in the proportion of advanced malignancies among rural residents has been noted and may be due to a combination of factors, including availability of screening services, demographic characteristics, and access to health care facilities. A cross-sectional study was conducted in 33 nonmetropolitan Iowa counties among randomly selected middle-aged farm and rural nonfarm adults to compare utilization of cancer early detection services. A total of 1,126 adults in 600 farm households and 1,092 adults in 589 rural nonfarm households provided information through a 155-item in-home interview. Differences in income, age, and health insurance coverage (including preventive services) between the farm and nonfarm study populations were found. Although farm men were less likely to have had a checkup during the past year than men in the nonfarm population, no difference was found for women. Overall, differences in screening behaviors were small. Larger differences between both populations were observed for use of mammograms, prostate examinations among men age 50 and older, use of sigmoidoscopy among women age 50 and older, and skin cancer examinations among both sexes. When controlling for demographic characteristics and insurance coverage, members of the farm and rural nonfarm population were equally likely to use multiple screenings according to ACS guidelines. Because of the increased risk of breast cancer, interventions aimed at increasing utilization of mammography among women age 50 and older should be implemented. Although the farm population was more likely to use skin examinations, prevalence should be increased substantially to counteract the continuing rise in skin cancer.
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PMID:Utilization of cancer early detection services among farm and rural nonfarm adults in Iowa. 1016 63


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