Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0006142 (
breast cancer
)
160,383
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Triple-negative
breast cancer
(TNBC) is an aggressive subtype of
breast cancer
that is often associated with biologic behavior with frequent distant metastasis.
FAT tumor suppressor homolog 4
(
FAT4
), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of
FAT4
in TNBC is still unclear. The aim of our study was to identify the role of
FAT4
in TNBC and examine the underlying molecular mechanisms. The expression of
FAT4
was evaluated by immunohistochemistry, western blotting, and qRT-PCR in a series of TNBC tissues. The effects of
FAT4
on the ability of cell proliferation, migration, and invasion were assessed by MTT assay and migration and invasion assays. We demonstrated that the repression of
FAT4
by shRNA could promote TNBC progression. Taken together, our findings provide evidence for a role of the
FAT4
cluster as a tumor suppressor in TNBC patients and may serve as potential novel targets for the treatment of TNBC.
...
PMID:FAT4 functions as a tumor suppressor in triple-negative breast cancer. 2789
