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Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetic mastopathy is uncommon but occurs in long-term insulin-dependent diabetic patients who develop hard palpable breast masses which mimic breast cancer and are occult mammographically. Ultrasound evaluation is useful to analyze the masses. There is a spectrum of ultrasound findings from marked acoustic shadowing to a vague hypoechoic area without shadowing. Ultrasound-guided core biopsy (CB) is recommended for a definitive diagnosis since fine needle aspiration biopsy (FNAB) yields insufficient material for diagnosis secondary to extensive fibrosis. Four of the 11 patients in our series had FNAB, which was reported as insufficient material for diagnosis. However, 10 of 11 patients with diabetic mastopathy were successfully diagnosed by ultrasound-guided CB, helping to avoid an unnecessary surgical excisional biopsy.
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PMID:Diabetic Mastopathy: Adjunctive Use of Ultrasound and Utility of Core Biopsy in Diagnosis. 1134 62

Diabetic mastopathy, although reported since 1984, is a poorly recognized diabetes complication. It more frequently affects pre-menopausal women with Type 1 diabetes mellitus and microvascular complications. The pathogenesis of this condition is believed to involve mammary tissue autoimmune reaction to the accumulation of abnormal matrix proteins, caused by hyperglycemia. The lesion often simulates breast cancer; its recognition, therefore, is important to avoid unnecessary diagnostic procedures and surgical treatments. We now report a case of diabetic mastopathy which clinically simulated breast cancer in a young pre-menopausal diabetic woman who, after sonography and mammography, was suggested surgery under suspicion of breast cancer. Histopathological examination by core-biopsy ruled out malignancy.
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PMID:Diabetic mastopathy: a case report. 1459 23

Diabetic mastopathy is an unusual stromal fibrotic lesion, but typically occurs in long-standing insulin dependent and younger diabetic patients. We report a case of diabetic mastopathy in an older diabetic patient. The patient was a 76-year-old woman with a history of type 2 diabetes mellitus for 13 years and 3 years of insulin treatment. She developed a 3 cm, hard, mobile nodule in the left breast. Mammography revealed a dense mass. Ultrasonography showed an irregular-shaped hypoechoic lesion with an unclear boundary and acoustic shadowing. Since fine needle aspiration biopsy delivered insufficient material and core needle biopsy did not yield any specific findings for diagnosis, clinically diabetic mastopathy was the prime suspect but breast cancer could be completely ruled out. Surgical excision was thus performed and diabetic mastopathy was confirmed pathologically. We report on this rare case of diabetic mastopathy in a 76 year-old type 2 diabetic patient.
Breast Cancer 2003
PMID:Diabetic mastopathy in an advanced elderly woman with insulin-dependent type 2 diabetes mellitus. 1463 19

Diabetic mastopathy is a rare condition that occurs in type I diabetic patients and that may mimic a breast cancer due to its intense fibrosis and inflammation. We report a 34 years old female consulting for a firm, painless and mobile retroareolar breast lump measuring 3.5 x 4 cm, that lead to the suspicion of a breast cancer. Mammography, mammary ultrasound and fine needle cytology were unspecific. A core biopsy confirmed the diagnosis of diabetic mastopathy. The patient continues under periodical assessments.
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PMID:[Diabetic mastopathy. Report of a case]. 1474 93

Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in a patient who has suffered from type I diabetes mellitus of long duration. Here we report a rare case of diabetic mastopathy that occurred in type II non-insulin dependent diabetes mellitus. This patient was a 63-year-old postmenopausal woman. Mammography, ultrasonography and MR imaging could not distinguish it from breast cancer. Although the core needle biopsy specimen showed fibrosis without evidence of malignancy, excisional biopsy was performed. Histological findings demonstrated typical diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy.
Breast Cancer 2006
PMID:An uncommon case of diabetic mastopathy in type II non-insulin dependent diabetes mellitus. 1675 19

Diabetic mastopathy is an uncommon disorder of the breast seen mostly in young women suffering from type 1 diabetes mellitus. The presenting symptom is a rapidly growing breast lump that may simulate breast cancer. Clinically and radiologically it can be indistinguishable from breast carcinoma. Recognizing this clinical entity, in addition to close collaboration between the clinician and the pathologist can facilitate its early diagnosis, avoiding unnecessary alarm for the patient. A 36 years old patient with a long-standing type 1 diabetes mellitus was admitted to surgery for a rapidly growing left breast lump. Excisional biopsy of the lump revealed diabetic mastopathy.
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PMID:[Diabetic mastopathy]. 1747 28

Diabetic mastopathy is a source of diagnostic confusion with breast carcinoma. The association between mastopathy and Type I and II diabetes of long duration has been reported, but this clinical condition is poorly recognized since the clinical, mammographic, and sonographic findings simulate breast cancer. We report a case of diabetic fibrous mastopathy with suspicious clinical and imaging findings in order to draw the attention of physicians to this possibility when encountering similar lesions in the breast of diabetic patients.
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PMID:Diabetic mastopathy mimicking breast cancer. 1941 Oct 32

Diabetic mastopathy is a recently described pathological entity. Little is known about this benign condition. It usually occurs in young patients with type 1 diabetes, or having an autoimmune disorders. Clinically, this mastopathy simulates a breast cancer. Graphic tests are not very informative. The diagnosis is histological. Through a case of diabetic mastopathy occurring in a patient with diabetes on insulin for 16 years and carries multiple degenerative complications, we recall the clinical, radiological and outcome of this disease.
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PMID:[Diabetic mastopathy]. 2097 84

The present review outlines the various issues of breast pathology in diabetes. Diabetic mastopathy is an uncommon proliferation of fibrous tissue in the breast that mimics tumour. Breast arterial calcifications represent calcium deposits in the media of arterioles and are more frequently detected on mammograms of diabetic subjects. Importantly, type 2 diabetes mellitus (T2DM) has been associated with breast cancer, but the mechanism underlying this association is complex, since the two entities frequently co-exist and seem to share common aetiological factors and pathways. Furthermore, diabetes has been suggested to negatively affect breast cancer outcomes, but it is unclear whether better glycaemic control would ameliorate prognosis. Preliminary data suggest that antidiabetic treatment may also influence both the incidence and prognosis of breast cancer. However, available evidence is inconclusive and further research is needed. Therefore, treatment of diabetes should not be determined by its potential effect on breast cancer.
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PMID:The female breast and diabetes. 2141 85

Diabetic mastopathy (DMP) is a benign fibrous disease of the breast. DMP is closely associated with along-standing history of insulin-dependent diabetes mellitus and often demonstrates a palpable, hard, and nontender mass similar to breast cancer. In our study, excisional biopsy was performed for diagnosis in both patients. DMP is an uncommon benign fibrous disease of the breast that is difficult to differentiate from breast cancer by clinical examination. Breast ultrasonography and mammography are recommended. Core biopsy should be performed if the lesions become clinically or radiologically suspicious. Excisional biopsy should be performed if malignancy cannot be excluded. Regarding mastectomy, we think that the patient's preference is very important; physicians can never make decisions for patients no matter how certain we are about nonmalignancy.
Clin Breast Cancer 2011 Dec
PMID:Diabetic mastopathy mimicking breast cancer: two case reports. 2199 12


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