Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0006142 (breast cancer)
 160,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The use of oral contraceptives should at all times be under physician's control. Most contraindications and complications from oral contraceptives are now a thing of the past, when higher doses were prescribed. However oral contraceptives are still responsible for many side effects and complications. Some of these are gastrointestinal problems; menstruation disorders, such as spotting or amenorrhea; decreased libido; increase in body weight; mastodynia; blood coagulation effects; lipid and carbohydrate metabolic effects; ophthalmological and dermatological problems; and, possibly, an increase in susceptibility to some infectious diseases. Patients with hypertension; with heart or hepatic diseases; with a history of family thrombolic accidents; with diabetes; or hyperthyroidism should utilize another form of contraception. Oral contraceptives are totally contraindicated for obese or emotionally depressed people, for pregnant or nursing mothers, for women with uterine or breast cancer, and for adolescents.
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PMID:[Principle complications and contraindications of the use of oral contraceptives]. 15 84

Pregnancy-specific beta 1-glycoprotein, SP1, was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP1 or SP1-like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera from patients with infectious diseases, and in none out of 15 sera from non-pregnant healthy individuals. SP1 thus does not seem to be ectopically produced in vivo by the types of cancer studied, but is probably highly specific for the normal and malignant trophoblast.
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PMID:Is SP1 (pregnancy specific beta 1 glycoprotein) elevated in cancer patients? 31 95

Analysis of age-standardized death rates for the main categories of deaths, over the period 1951--1977, shows a three-quarter fall in mortality from infectious diseases, a reduction of mortality from cardiovascular disease more accentuated in women (-46%) than in men (-23%) and a decrease in mortality from tumors in women only (-21%). Suicide rates slightly increased and mortality from accidents started to decrease in 1971, more markedly in men than in women. As regards the last category including all other causes of deaths, a decline in mortality of approximately a half in both sexes was observed. Calculation of the potential years of life lost between ages 1 and 70 (PYLL) reveals that in men, for the year 1977, 25% were due to accidents, 23% to tumours and 22% to cardiovascular diseases, whereas in women tumours came first (36%) and preceded cardiovascular disease (17%). Analysis of PYLL by individual cause of death shows, in decreasing order of importance, for men: motor accidents, suicide, ischaemic heart disease, other accidents, cancer of lung, cerebrovascular disease and cirrhosis of liver, and for women: suicide, breast cancer, motor accidents, other accidents, cerebrovascular disease, ischaemic heart disease and uterine cancer. Finally, life expectancy at birth increased, over the period 1951--1977, from 66.4 to 71.8 years in men and from 71.0 to 78.4 years in women, which ranks Switzerland third among the 10 industrialized countries studies.
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PMID:[Mortality trends in Switzerland 1951-1977. Principal categories of the causes of death]. 51 12

CHESS (the Comprehensive Health Enhancement Support System) is an interactive, computer-based system to support people facing health-related crises or concerns. CHESS provides information, referral to service providers, support in making tough decisions and networking to experts and others facing the same concerns. CHESS will improve access to health and human services for people who would otherwise face psychological, social, economic or geographic barriers to receiving services. CHESS has developed programs in five specific topic areas: Academic Crisis, Adult Children of Alcoholics, AIDS/HIV Infection, Breast Cancer and Sexual Assault. The lessons learned, and the structures developed, will serve as a model for future implementation of CHESS programs in a broad range of other topic areas. CHESS is designed around three major desired outcomes: 1) improving the emotional health status of users; 2) increasing the cost-effective use of health and human services; and 3) reducing the incidence of risk-taking behaviors that can lead to injury or illness. Pilot-testing and initial analysis of controlled evaluation data has shown that CHESS is extensively used, is useful and easy-to-use, and produces positive emotional outcomes. Further evaluation in continuing.
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PMID:CHESS: a computer-based system for providing information, referrals, decision support and social support to people facing medical and other health-related crises. 148 60

A proposed community health education system is described for implementation in Kampuchea, Laos, and Vietnam which addresses the problems of maternal care, improved nutrition, prevention of infectious diseases, and screening for breast cancer. Success of this proposal is dependent on cost effectiveness, the economic viability after donor funding ceases, sustainability through community interest, and adequate monitoring and evaluative procedures. Community participation is a major determinant in program success. The lack of participation may be due to a lack of community awareness and resentment of "topdown" messages, authoritarian behavior, and cultural insensitivity. The community health program initially requires national governments to provide salaries alone. Cultural sensitivity is achieved through involvement of primarily national health professionals, a few nonnationals who have been informed of Indochinese traditions, and a core of local people at the village level. The System 1) established and educates key persons (advisory team, community health education unit, community health workers (CHWs), and women's groups) in the system, 2) implements the programs, and 3) monitors and evaluates. The women's group is the most important for program success. 6 education modules make up the program, i.e., a medical module on maternal care (pregnancy and prenatal and postnatal care), proper nutrition, prevention of infectious diseases (germ theory, immunization, personal hygiene, environmental hygiene, and preventing sexually transmitted diseases), and screening for breast and cervical cancer. Other modules are on teaching methods, the use of teaching aids, revision of modules, female community health worker training, video production techniques, a national awareness media component, and evaluation techniques. The CHWs teach the women's groups and villages about health prevention and behavior. Women's groups provide feedback and modify the program and in return develop self-confidence in leadership roles in the family, community, and country.
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PMID:A Community Health Education System to meet the health needs of Indo-Chinese women. 160 46

Weekly low dose mitoxantrone (3 mg/m2) plus doxorubicin (8 mg/m2) was administered as second-line chemotherapy to 33 patients with advanced breast cancer. Four out of 28 evaluable patients (14%) obtained a partial response with a median duration of 34 weeks (range 18-67+ weeks), while 8 patients (29%) showed stable disease with a median duration of 28 weeks (range 11+-60 weeks). Gastrointestinal toxicity and alopecia were mild. Grade II and III leukopenia occurred in 63% of the courses without serious infectious disease. Four patients experienced an asymptomatic drop of 16-20% in the left ventricular ejection fraction (LVEF) after relatively low cumulative doses of each drug, and one patient with a history of pericarditis carcinomatosa and mediastinal irradiation developed a heart failure. In conclusion, this second-line combination treatment had moderate activity in breast cancer and caused only few subjective side effects, especially with respect to gastrointestinal symptoms.
Breast Cancer Res Treat 1992
PMID:Weekly low-dose mitoxantrone plus doxorubicin as second-line chemotherapy for advanced breast cancer. 162 16

When defined in terms of markers for normal cell lineages, most invasive breast cancer cells correspond to the phenotype of the common luminal epithelial cell found in the terminal ductal lobular units. Luminal epithelial cells cultured from milk, which have limited proliferative potential, have now been immortalized by introducing the gene encoding simian virus 40 large tumor (T) antigen. Infection with a recombinant retrovirus proved to be 50-100 times more efficient than calcium phosphate transfection, and of the 17 cell lines isolated, only 5 passed through a crisis period as characterized by cessation of growth. When characterized by immunohistochemical staining with monoclonal antibodies, 14 lines showed features of luminal epithelial cells and of these, 7 resembled the common luminal epithelial cell type in the profile of keratins expressed. These cells express keratins 7, 8, 18, and 19 homogeneously and do not express keratin 14 or vimentin; a polymorphic epithelial mucin produced in vivo by luminal cells is expressed heterogeneously and the pattern of fibronectin staining is punctate. Although the cell lines have a reduced requirement for added growth factors, they do not grow in agar or produce tumors in the nude mouse. When the v-Ha-ras oncogene was introduced into two of the cell lines by using a recombinant retrovirus, most of the selected clones senesced, but one entered crisis and emerged after 3 months as a tumorigenic cell line.
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PMID:Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus. 170 84

In 1901, 20% of autopsied subjects in Trieste were under the age of 30 and 28.8% were over 70. By 1985, only 0.2% were under 30 years of age and 74.5% over 70. An analysis of autopsy reports for 1901 reveals that the primary causes of death at that time were tuberculosis (22.4%), acute pulmonary infections (13.7%) and malignant neoplasms (10.6%). Other pathological conditions found at autopsy were infectious lesions (10.4%), chronic obstructive pulmonary disease (10.2%), arteriosclerosis (only 6.4%), syphilis (4.7%), nutritional deficiency (4.7%), cirrhosis of the liver (4.6%) and acute infections (1.1%). Overall, infectious diseases accounted for 55% of deaths in 1901. In 1985, the cause of death was infection in only 3.7% of cases. During the period analysed, the percentage of deaths from cancer tripled and mean length of survival increased by more than 20 years. In 1901, the neoplasms found most frequently were gastric cancer in males (17.9%) and cancers of the uterus and ovary in females (both 13%). Lung cancer accounted for 7.7% of all deaths from malignant neoplasms in males, and breast cancer for 10.8% of such deaths among females. By 1985, lung cancer accounted for 32.4% of deaths from malignant neoplasms among males and breast cancer for 18% among females. Between 1901 and 1985, there were highly significant increases in the numbers of deaths due to arteriosclerosis and to malignant neoplasms in people of each sex.
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PMID:Changes in underlying causes of death during 85 years of autopsy practice in Trieste. 185 46

Unlike the days of Robert Koch when infectious diseases were the principal contributors to morbidity and mortality, today's illness and death are most often caused by noncommunicable diseases that have the special characteristics of resulting largely from one's own lifestyle, especially tobacco use and nutritional excesses. By "listening to nature", we can detect and identify risk factors for various types of cancer, explore their mechanisms of action, and execute preventive strategies leading to their reduction or modification, thereby, decreasing the incidence and mortality of disease. An example of the role of metabolic overload in carcinogenesis is the impact of an excessive intake of dietary fat on the development and progression of breast cancer. For the general pathogenesis of cancer, the risks associated with metabolic overloads are contrasted with those of low-level exposures. To broaden the impact of preventive medicine beyond factorial nutritional education in Germany, we recommend that (a) every medical school have a department of preventive medicine with emphasis on epidemiology and health promotion, and (b) all schools beginning in first grade have a comprehensive school health education program coordinated by a full-time health education teacher.
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PMID:Listen to nature. The challenge of lifestyle medicine. 195 Jan 72

The 1987-1988 health-for-all (HFA) monitoring exercise produced a considerable amount of quantitative and non-quantitative data which were used for the assessment of the progress towards HFA in the European Region. At the same time it demonstrated many shortcomings and problems with regard to the availability and quality of data. Relevance of replies to non-quantitative indicators leaves considerable room for improvements. Good or satisfactory relevance can only be found in about one-third of the country replies. Data on most morbidity indicators, except infectious diseases, were provided on average by one-third of the countries. Nearly two-thirds of the countries provided data on cervical and breast cancer and some occupational diseases. At least half of the data seem not to be comparable; some data are potentially comparable, depending on additional information to be collected. Perceived health estimates are collected by a few countries, but data are not directly comparable. Many countries conduct surveys at different times on one or more aspects of lifestyle. However, comparable data are restricted mainly to educational levels, smoking, alcohol and nutrients. Data on health services and resources are more promising, as they are provided by about two-thirds of the countries.
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PMID:Using regional indicators: the experience of Europe. 237 26


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