Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0005940 (bone disease)
 7,459 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Chloride channel 7 12.1
ubiquitin carboxy-terminal esterase 11.1
matrilin 4 11.1
suppression of tumorigenicity 5 11.1
sclerostin domain containing 1 10.5
RTDR1 10.5
CTSK protein 10.5
DEF8 10.5
PDCR 10.1
SLC23A3 9.7
JPD 9.7
TCIRG1 9.7
ZNF687 9.6
TNFRSF11A 9.5
AMDHD1 9.5
actin, alpha 2, smooth muscle, aorta 9.5
OSTM1 9.4
T-cell immune regulator 1 9.3
FAM98A 9.3
SCUBE3 9.3
CLCN7 9.3
SHISA3 9.3
ubiquitin thiolesterase 9.3
infantile malignant osteopetrosis 9.1
COL4A1 protein 9.1
CSS1 9.1
MCC-2 9.1
Talin 1 9.1
RIN3 8.9
pycnodysostosis 8.9
PTHR2 8.9
ARHGEF3 8.8
PSTPIP2 8.5
PTDSS1 8.5
USP32 8.5
SH3-domain binding protein 2 8.5
TMEM38B 8.5
RUNX2 protein 8.4
EDA protein 8.4
MAGP2 8.4
CREB3L3 8.3
GBP4 8.3
chloride channel 7 8.2
osteoclast-associated receptor 8.2
FKBP65 8.2
ANKH 8.1
PP1A 8.1
ALPL 8.1
FAM167A 8.1
sFRP-2 8.0
Sclerostin 8.0
PLEKHM1 8.0
sclerostin 8.0
EXT2 8.0
PSME2 8.0
DC-STAMP 8.0
Dickkopf-1 8.0
SNX10 7.9
Exostosin-1 7.9
FGF23 7.8
RANK 7.8
TRIC-B 7.8
LRP protein 7.8
EXTL1 7.8
ARH-77 7.8
parathyroid hormone 7.8
FKBP10 7.7
osteoprotegerin 7.7
cherubism 7.7
25-hydroxyvitamin D3-1alpha-hydroxylase 7.7
NHA2 7.7
Endomucin 7.7
ARHGDIA 7.7
OPG 7.7
PLS3 7.6
BDA1 7.6
tissue-nonspecific ALP 7.6
SLC29A3 7.6
Selenoprotein O 7.5
IFITM5 7.5
more...
Disease
OPTA1 12.1
Structural and functional abnormalities of the kidney 12.1
High turnover bone disease 12.1
Aluminum bone disease 12.1
Osteomesopycnosis 12.1
bone disease 12.1
Neonatal rickets 12.1
Echinococcus granulosus infestation 12.1
Osteopenia of prematurity 11.7
Adynamic bone disease 11.6
Aluminum-related osteomalacia 11.5
Azotemic osteodystrophy 11.1
Alcohol-induced chronic pancreatitis 11.1
Renal function disorder 11.1
Malignant gastrinoma 11.1
Disappearing bone disease 11.1
Fibrous dysplasia of bone 10.6
renal osteodystrophy 10.3
Hungry bone syndrome 10.3
Dysosteosclerosis 10.1
Aluminum intoxication 10.1
Nonpersistence 10.1
familial hypophosphatemia 10.0
Metabolic bone disease 9.8
JPD 9.7
Autosomal dominant osteosclerosis 9.7
Hodgkin's granuloma 9.7
Mechanical low back pain 9.7
arthritis deformans 9.7
Periarticular calcification 9.7
Pneumococcal arthritis 9.7
osteodystrophy 9.6
Craniometaphyseal dysplasia 9.6
Medullary nephrocalcinosis 9.6
Primary osteoporosis 9.6
Brown tumor 9.5
moria 9.5
HHRH 9.5
cancer seeding 9.5
Generalized osteopenia 9.5
osteomalacia 9.4
Secondary hyperparathyroidism 9.3
Dietary calcium deficiency 9.3
Pycnodysostosis 9.2
age related bone loss 9.2
Metachondromatosis 9.1
SPONASTRIME 9.1
Proximal myopathy 9.1
Fibrous dysplasia 9.0
renal rickets 9.0
Idiopathic osteoporosis 9.0
Ectopic parathyroid adenoma 8.9
Polyostotic fibrous dysplasia 8.9
Paget's Disease 8.9
EXT3 8.8
Calcium deficiency 8.8
esophageal irritation 8.7
melorheostosis 8.7
osteopoikilosis 8.7
osteitis 8.6
malignant myeloma 8.6
hypophosphatasia 8.5
Grisel's syndrome 8.5
Distal RTA 8.5
hypercalcemia of malignancy 8.5
hyperparathyroidism 8.4
hyperphosphatemia 8.4
Osteopathia striata 8.4
Walker carcinoma 256 8.4
osteopetrosis 8.3
osteosclerosis 8.3
Hepatic osteodystrophy 8.3
Lenz-Majewski syndrome 8.3
Neonatal hypocalcemia 8.3
Kohler's disease 8.3
IBMPFD 8.2
Non-secretory myeloma 8.2
parathyroid hyperplasia 8.1
Tertiary syphilis 8.1
glycinuria 8.1
more...
Symptom
bone pain 8.7
joint symptom 8.7
Musculoskeletal discomfort 8.3
cervical spine dysfunction 8.2
High weight 7.7
phosphatemia 7.6
musculoskeletal disability 7.5
Reticulocytosis 6.4
Inflammatory pain 5.8
prominent nose 5.7
gumma 5.6
hip pain 5.2
disturbed balance 5.2
anal pain 5.2
facial droop 5.1
hepatosplenomegaly 5.0
thigh pain 5.0
limb pain 5.0
muscle cramps 4.8
jaw pain 4.5
renal colic 4.4
inanition 4.3
back pain 4.2
heel pain 4.2
physical symptom 4.1
chronic back pain 4.1
Catch 4.1
Decreased activity 4.0
lassitude 3.9
clubbing 3.8
hyperemesis 3.8
Fluctuation 3.8
elbow pain 3.8
arthralgia 3.5
groin pain 3.5
cancer pain 3.3
low back pain 3.2
Spots 3.2
weakness 3.2
blackout 3.2
thinning 3.2
polyuria 3.1
physical appearance 3.1
POA 3.0
hot flashes 3.0
ankle pain 3.0
Postoperative pain 3.0
polydipsia 3.0
pain 2.9
Gastrointestinal symptoms 2.9
dental pain 2.8
rales 2.7
Wind 2.7
leg pain 2.7
knee pain 2.6
clonus 2.5
splenomegaly 2.5
sciatica 2.5
torticollis 2.4
enuresis 2.4
bloating 2.4
wrist pain 2.3
abdominal discomfort 2.3
hepatomegaly 2.1
paresthesia 2.1
Stiffness 2.1
otalgia 2.1
constipation 2.1
joint stiffness 2.0
emaciation 2.0
microbial colonization 2.0
ENT 2.0
tense 2.0
myalgia 2.0
cachexia 1.9
rhinorrhea 1.9
decreased appetite 1.9
hypotonia 1.9
night sweats 1.8
fatigue 1.8
more...
Drug
Bonefos 10.0
Zemplar 9.5
Aredia 9.3
Epimedium herb 9.3
Ibandronate 9.2
Sevelamer 9.0
Zoledronic acid 9.0
LeukoScan 8.6
Zoledronic acid 8.5
Etidronate disodium 8.5
Ceredase 8.5
Sevelamer hydrochloride 8.4
Clodronate 8.3
Calcifediol 8.3
Actonel 8.3
Denosumab 8.2
Lanthanum carbonate 8.2
Sevelamer carbonate 8.2
Cerezyme 8.0
Cerezyme 7.9
Dilaudid 7.7
EHDP 7.6
Rocaltrol 7.6
Cinacalcet 7.5
Alfacalcidol 7.5
Fosamax 7.5
PTH 7.4
Risedronate sodium 7.3
Cinacalcet hydrochloride 7.1
Januvia 6.8
Teriparatide 6.7
Femara 6.1
Revlimid 5.9
Bortezomib 5.8
APD 5.8
Hakka 5.8
Pyridostigmine bromide 5.6
Sodium thiosulfate 5.5
Sodium acetate 5.4
Trapidil 5.2
Vindesine 5.2
Vindesine 5.2
DMSA 5.1
Lenalidomide 5.0
Arimidex 4.9
Vitamin K2 4.8
CTX 4.8
CTX 4.8
Calcipotriol 4.7
Tenofovir disoproxil fumarate 4.7
Artesunate 4.6
Salmon calcitonin 4.6
Dial 4.5
Tibolone 4.5
SrCl2 4.5
IL-11 4.5
Maraviroc 4.5
Fragmin 4.5
ARA-C 4.2
Cytidine 4.2
Activin 4.1
PFT 4.1
metformin hydrochloride 4.1
Zoladex 4.0
CTX 4.0
Epoetin 4.0
Vitamin K 3.9
Lactase 3.9
CED 3.9
Pregnenolone 3.9
Premarin 3.8
Myricetin 3.8
Zoladex 3.8
Nephron 3.6
Everolimus 3.6
HPMPC 3.6
Raloxifene 3.6
TRM 3.5
PMPA 3.5
Tenofovir 3.4
more...
Enzyme
cathepsin K 6.7
glucocerebrosidase 6.6
MDP 6.0
alkaline phosphatase 5.9
CCS1 5.7
20beta-hydroxysteroid dehydrogenase 5.4
1-hydroxylase 5.2
proline iminopeptidase 5.1
protein farnesyltransferase 4.8
lecithin:retinol acyltransferase 4.7
BBE 4.7
alpha-L-iduronidase 4.5
homogentisate 1,2-dioxygenase 4.5
glucosylceramide synthase 4.2
AGT 4.1
acid phosphatase 4.1
fumarylacetoacetate hydrolase 3.9
EPT 3.9
dihydropyrimidine dehydrogenase 3.8
lysyl oxidase 3.8
tryptophanyl-tRNA synthetase 3.7
type III procollagen 3.6
MIP 3.6
prostate-specific membrane antigen 3.6
prostate-specific antigen 3.5
matrix metalloproteinase 9 3.5
CEP 3.5
FAST 3.5
PMT 3.4
chymopapain 3.4
chymopapain 3.3
AMP-activated kinase 3.2
prolidase 3.1
thymidine phosphorylase 3.0
CEP 2.9
isopeptidase 2.9
15-hydroxyprostaglandin dehydrogenase 2.8
GCA 2.6
lactase 2.6
ornithine aminotransferase 2.6
farnesyltransferase 2.5
matrix metalloproteinase 2 2.5
proteasome 2.4
PRA 2.4
PAT 2.3
calcineurin 2.2
PRE 2.2
transglutaminase 2.1
IKK 2.1
AST 2.1
farnesyltransferase 2.0
caspase-1 2.0
CPT 2.0
granzyme B 2.0
CPT 1.9
RNase T1 1.8
11beta-hydroxysteroid dehydrogenase 1.7
phenylalanine hydroxylase 1.6
indoleamine 2,3-dioxygenase 1.6
gamma-glutamylcysteine synthetase 1.6
transpeptidase 1.5
TOR 1.5
gamma-glutamyl transpeptidase 1.5
urokinase-type plasminogen activator 1.5
CPT 1.5
mitogen-activated protein kinase 1.4
5'-nucleotidase 1.4
leucine aminopeptidase 1.4
collagenase 1.4
dipeptidyl peptidase IV 1.4
ERK 1.3
GSK 1.3
renin 1.3
caspase-8 1.3
lactate dehydrogenase 1.3
AOR 1.3
prostaglandin synthetase 1.2
PAM 1.2
CD10 1.1
cathepsin L 1.1
more...
Compound
Doxercalciferol 9.0
Pamidronate 8.9
Rodan 8.9
Paricalcitol 8.3
EHDP 7.7
Angelicin 7.6
Deoxypyridinoline 7.6
Dilaudid 7.5
Vindoline 7.5
Sulfuretin 7.4
Risedronate 7.4
25-Hydroxyvitamin D 7.3
proline-hydroxyproline 7.3
vitamin D 7.0
Minocycline hydrochloride 6.9
25-hydroxycholecalciferol 6.8
Alendronate 6.8
Novex 6.7
Pyridinoline 6.6
HPT 6.6
Alendronate 6.6
Calcium carbonate 6.5
Aluminum hydroxide 6.4
25-dihydroxycholecalciferol 6.3
Vitamin D 6.2
Tetracycline hydrochloride 6.1
BMD 6.1
Glabridin 5.9
Indoxyl sulfate 5.9
Ferric citrate 5.8
Succinylacetone 5.8
3-aminobenzoic acid 5.6
DMO 5.5
ALP 5.5
Vitamin D3 5.5
DGE 5.4
DGE 5.4
DGE 5.4
Sodium acetate 5.4
phosphorus 5.4
BAP 5.3
aluminum 5.3
Geigy 5.2
Betulin 5.2
Calcitonin 5.2
DBM 5.1
Ursodeoxycholic acid 5.1
DBM 5.1
BAPN 5.0
Gambogic acid 5.0
Vitamin D3 5.0
4-hydroxyproline 4.9
4-hydroxyproline 4.9
4-hydroxyproline 4.9
4-hydroxyproline 4.9
4-hydroxyproline 4.9
4-hydroxyproline 4.9
TAR 4.8
isonicotinic acid 4.8
pentosidine 4.8
Isoliquiritigenin 4.7
Sitosterol 4.7
CUE 4.6
Enoxacin 4.6
DLT 4.5
Hydroxyproline 4.5
Hesperetin 4.5
Dial 4.5
Alizarin 4.5
Sparfloxacin 4.4
Calcein 4.4
strontium 4.4
calcium 4.4
Mithramycin 4.4
Tauroursodeoxycholic acid 4.3
Vitamin K1 4.3
DFO 4.3
Foscarnet 4.3
Mangiferin 4.2
Matrine 4.2
more...