Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0005940 (bone disease)
7,459 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein parathyroid hormone 855 alkaline phosphatase 680 Sep 447 PTH 274 osteocalcin 270 RANKL 233 collagen 227 chronic renal failure 222 Mol 218 osteoprotegerin 168 osteogenic 124 calcitonin 122 RANK 117 type I collagen 116 cytokine 91 tartrate-resistant acid phosphatase 86 sclerostin 75 insulin 74 vitamin D receptor 73 MRI 73 OPG 71 parathormone 70 IL-6 60 She 60 FGF23 58 catenin 54 BMD 52 acid phosphatase 50 X-linked 49 hemoglobin 47 albumin 47 cathepsin K 46 ALP 45 osteosarcoma 44 Dickkopf-1 44 TNF 43 macrophage colony-stimulating factor 42 interleukin-6 41 growth hormone 41 MDP 40 parathyroid hormone-related protein 38 osteopontin 37 tumor necrosis factor 37 CTX 37 glucocerebrosidase 35 proteasome 35 Sclerostin 35 gut 34 proteasome inhibitor 34 Klotho 34 Parathyroid hormone 32 TRAP 32 GFR 31 Alkaline phosphatase 28 ERK 26 Osteocalcin 26 p38 25 bone morphogenetic protein 25 FDG 24 MAPK 24 cage 24 serum albumin 23 PDB 23 erythropoietin 22 estrogen receptor 22 C-reactive protein 22 RUNX2 21 receptor activator of NF-kappaB ligand 21 renin 21 type I procollagen 21 prostate-specific antigen 20 COL1A1 20 calcium-sensing receptor 20 BMP-2 20 Calcitonin 20 bone) 20 DKK1 19 ALPL 19 PI3K 19 TNFRSF11A 18 more...

Disease bone disease 7459 osteoporosis 1434 cancer 859 multiple myeloma 758 hyperparathyroidism 730 tumor 559 hypercalcemia 493 osteomalacia 489 bone metastases 390 renal osteodystrophy 390 metastases 362 chronic renal failure 347 renal disease 332 PDB 290 renal failure 273 breast cancer 265 diabetes 257 vitamin D deficiency 214 primary hyperparathyroidism 200 anemia 198 rickets 192 cardiovascular disease 186 prostate cancer 180 osteitis 172 hyperphosphatemia 172 osteomyelitis 131 dysplasia 126 hypertension 122 osteopetrosis 119 osteodystrophy 118 carcinoma 110 osteogenesis imperfecta 104 liver disease 103 uremia 97 pathological fracture 89 tumor growth 87 malabsorption 84 malnutrition 83 Gaucher disease 79 spinal cord compression 79 rheumatoid arthritis 68 Best 66 obesity 64 osteosclerosis 64 renal insufficiency 61 hypercalciuria 60 Chronic kidney disease (CKD) 58 hypoparathyroidism 58 hyperostosis 57 lymphoma 56 osteoarthritis 56 adenoma 56 HIV 55 arthritis 54 osteosarcoma 54 Secondary hyperparathyroidism 53 BMD 52 leukemia 51 hypophosphatasia 51 lung cancer 50 cystic fibrosis 50 nephrolithiasis 49 metastatic breast cancer 46 wasting 46 Fibrous dysplasia 44 renal impairment 43 cirrhosis 42 tumor progression 41 atherosclerosis 41 thalassemia 40 hypogonadism 40 type 2 diabetes 38 myopathy 38 CTX 37 inflammatory bowel disease 37 hypercalcemia of malignancy 37 proteinuria 37 celiac disease 36 monoclonal gammopathy of undetermined significance 35 parathyroid hyperplasia 34 more...

Symptom pain 451 bone pain 313 weakness 83 back pain 53 fatigue 43 hepatosplenomegaly 33 seizures 31 thinning 24 low back pain 22 collapse 22 diarrhea 19 arthralgia 19 abdominal pain 19 headache 18 hip pain 16 anesthesia 15 splenomegaly 13 nausea 12 constipation 10 anorexia 10 vomiting 10 analgesia 8 discomfort 7 discomfort 7 cancer pain 7 dyspnea 6 polyuria 6 hepatomegaly 6 myalgia 6 distraction 6 muscle cramps 6 cachexia 5 thigh pain 5 ENT 5 limb pain 5 paresthesia 5 phosphatemia 5 hypotonia 5 polydipsia 4 knee pain 4 Wind 4 respiratory distress 4 renal colic 4 spasm 4 nausea and vomiting 4 overweight 3 chronic back pain 3 physical appearance 3 pelvic pain 3 tremor 3 Ill 3 numbness 3 clubbing 3 leg pain 3 acute pain 3 shoulder pain 2 neck pain 2 hot flashes 2 chest pain 2 groin pain 2 tense 2 anal pain 2 hypothermia 2 Decreased activity 2 Postoperative pain 2 musculoskeletal disability 2 starvation 2 syncope 2 regurgitation 2 abdominal discomfort 2 tinnitus 2 dental pain 2 torticollis 2 disturbed balance 2 acidity 2 enuresis 2 Fluctuation 2 rhinorrhea 2 sciatica 2 vertigo 2 more...

Drug PTH 278 Dial 168 Zoledronic acid 69 Zoledronic acid 60 CTX 38 CTX 38 Denosumab 37 CTX 37 Nephron 37 Nephron 35 EHDP 23 Ibandronate 21 Bortezomib 20 Clodronate 19 CSF 15 Sevelamer 13 APD 12 Cardiovasc 9 Cinacalcet 9 Teriparatide 8 ROS 8 Leaf 8 Aredia 7 Activin 7 ascorbate 7 ROC 7 vitamin E 7 lysine 7 DMSA 6 Lanthanum carbonate 6 Ceredase 6 Cerezyme 6 lactose 6 Dermatol 6 IL-11 6 ENT 6 Vitamin K 5 Gel 5 Lenalidomide 5 MRC 5 Bonefos 4 Growth hormone 4 Growth hormone 4 caffeine 4 Sevelamer hydrochloride 4 Alliance 4 Monit 4 pyridoxal phosphate 4 Tacrolimus 3 CaCl2 3 CaCl2 3 Fosamax 3 IL-2 3 Asthma 3 Cerezyme 3 CaCl2 3 PFT 2 Alfacalcidol 2 Artesunate 2 Rocaltrol 2 PMPA 2 Raloxifene 2 Adriamycin 2 NVP 2 Zemplar 2 TAC 2 Vitamin E 2 Docetaxel 2 Prednisolone 2 citric acid 2 Estrogens 2 DM1 2 Everolimus 2 Ethanol 2 CED 2 DPA 2 EPA 2 niacin 2 ADM 1 Zoladex 1 more...

Enzyme alkaline phosphatase 680 mitogen-activated protein kinase 61 ERK 57 acid phosphatase 50 cathepsin K 46 MDP 40 proteasome 35 glucocerebrosidase 33 renin 21 prostate-specific antigen 19 calcineurin 18 lactate dehydrogenase 17 protein kinase 16 MIP 14 ATPase 13 reverse transcriptase 12 collagenase 11 focal adhesion kinase 11 caspase-3 10 luciferase 10 alanine aminotransferase 9 aspartate aminotransferase 8 superoxide dismutase 7 urokinase-type plasminogen activator 7 creatine kinase 7 matrix metalloproteinase 9 6 AST 6 gamma-glutamyl transpeptidase 6 caspase-1 6 transglutaminase 5 1-hydroxylase 5 ACE 5 IKK 5 protein kinase C 5 prostate-specific membrane antigen 5 CD10 5 GSK 4 catalase 4 adenylate cyclase 4 ACS 4 lysyl oxidase 4 dihydropyrimidine dehydrogenase 4 endonuclease 4 MEK 4 caspase-8 4 phosphatidylinositol 3-kinase 4 transcriptase 3 AGT 3 lactase 3 matrix metalloproteinase 2 3 neuraminidase 3 granzyme B 3 CPT 3 NO synthase 3 CPT 3 RNA polymerase 3 CPT 3 glutathione S-transferase 2 farnesyltransferase 2 PRE 2 carbonic anhydrase 2 glutathione peroxidase 2 thymidine phosphorylase 2 AMP-activated protein kinase 2 elastase 2 CEP 2 CEP 2 trypsin 2 MMP 2 phospholipase C 2 type III procollagen 2 PARP 2 phosphodiesterase 2 protein farnesyltransferase 2 plasmin 2 alpha-L-iduronidase 2 PRA 2 5'-nucleotidase 2 glucosylceramide synthase 2 FAST 2 more...

Compound calcium 1602 Clin 1034 vitamin D 850 phosphate 728 Dec 505 phosphorus 445 aluminum 262 creatinine 171 Dial 168 Vitamin D 118 DNA 95 carbonate 93 water 89 sodium 82 iron 81 glucose 81 nitrogen 79 BMD 52 oxygen 50 ALP 45 TNF 43 25-dihydroxycholecalciferol 43 phosphoric acid 39 urea 38 CTX 38 acetate 37 sulfate 35 Pamidronate 30 potassium 29 ethanol 28 strontium 26 MDA 25 His 25 zinc 23 hydroxide 22 cadmium 21 25-hydroxycholecalciferol 21 oxalate 21 EHDP 20 salt 20 Calcitonin 19 AMP 18 hydrogen 17 HPT 16 Collagen 15 nitric oxide 15 cysteine 15 fluorine 15 Alendronate 15 TAR 14 cAMP 14 BMC 13 tyrosine 13 Alendronate 12 Estrogen 12 Mg2+ 12 proline 12 arginine 12 galactose 12 MTT 12 Estrogen 12 aldosterone 12 copper 10 EDTA 10 ATP 10 Parenteral 10 methionine 10 EDTA 10 Vitamin D3 9 Optimal 9 Neuronal 9 NH2 9 BAP 8 homocysteine 8 lysine 8 iodine 8 leucine 8 Paricalcitol 8 serine 7 Risedronate 7 more...

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