Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0005940 (bone disease)
 7,459 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of chronic alcohol consumption on the concentration of 25-hydroxyvitamin D3, total retinol, and retinol-binding protein in serum was studied in chronic alcoholics (n = 12) and controls (n = 19). Ethanol intake during the last year was 178 +/- 116 and 3.7 +/- 4.5 g/day, respectively (p less than 0.002). Of the alcoholics, 58% had a concentration of 25-hydroxyvitamin D3 below lower limit of reference (20 ng/ml). Estimated dietary intake of vitamin D last year was not significantly different for the alcoholics and controls. Concentration of calcium in serum was significantly lower in alcoholics than in controls (p less than 0.05). The serum concentration of retinol and retinol-binding protein was similar in the two groups. These observations may be of relevance for some of the clinical findings related to bone disease among heavy alcohol consumers.
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PMID:Effect of alcohol consumption on serum concentration of 25-hydroxyvitamin D3, retinol, and retinol-binding protein. 376 53

The possible contribution of hypervitaminosis A to bone disease in uremia was examined in 50 dialysis-treated patients with end-stage chronic renal failure. None of the patients received dietary supplements of vitamin A. In common with previous investigations, plasma concentrations of total vitamin A and the retinol-binding protein (RBP) were increased in patients, but the molar ratio of vitamin A to RBP was significantly lower than control values. A significant correlation was noted between concentrations in plasma of vitamin A and RBP. No significant relationship was found between vitamin A or the vitamin A/RBP ratio, and the measured biochemical, radiographic, or histological indices of hyperparathyroidism and bone resorption. We conclude that the elevated plasma values of vitamin A in uremia are largely attributable to the high concentrations of RBP and do not contribute significantly to the pathogenesis of renal osteodystrophy.
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PMID:Vitamin A and hyperparathyroid bone disease in uremia. 668 72