Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0005940 (bone disease)
 7,459 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Osteoporosis is a bone disease of great sociomedical and economic importance. Postmenopausal women are primarily affected. Pathogenesis is of multifactorial origin. In Western countries, reduced physical activity and an inadequate nutritional calcium supply are important aspects besides decreased postmenopausal oestrogen secretion. Food statistics confirm that in the Federal Republic of Germany calcium intake is below the DGE recommendation in almost all age groups, especially in women. Calcium may play a role in prevention of osteoporosis. The paper reports on individual measures to enhance calcium intake. Furthermore, the influence of the postmenopausal status on calcium metabolism and calcium requirement is demonstrated. Finally, the importance of other nutritional aspects for the manifestation of osteoporosis is discussed.
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PMID:[Nutrition and primary osteoporosis]. 189 81

Osteoporosis primarily affects women and is a bone disease of great social, medical and economic importance. The pathogenesis is thought to be of multifactorial origin. The current work discusses nutritional aspects relative to osteoporosis. In this aspect, calcium supply seems to have the largest preventional importance. In contrast, food statistics and individual food records show that calcium intake of females is below the DGE's recommendation of 800 mg/daily. Furthermore, in view of skeletal integrity, calcium intake should be increased up to 1,500 mg/daily after menopause, because of endocrinological changes in calcium metabolism. Therefore, calcium intake on the whole is usually found to not be sufficient. The importance of further nutritional aspects for manifestation of osteoporosis are discussed. In some cases, influences on skeletal integrity are quite evident, whereas the literature has only infrequently drawn conclusions about the pathogenesis of osteoporosis.
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PMID:[The contribution of nutrition to the pathogenesis of osteoporosis]. 265 14