Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0005684 (
bladder cancer
)
16,431
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Growth factor receptor-bound protein 7
(
GRB7
) has been found closely related to the occurrence and development of various tumors, but its function in
bladder cancer
has not yet been elucidated. The study is aiming at investigating the expression and function of
GRB7
in
bladder cancer
. The Cancer Genome Atlas (TCGA) database was selected to analyze mRNA levels of
GRB7
in
bladder cancer
. RT-qPCR and Western blot were conducted to detect the expression of
GRB7
in normal bladder epithelial cells, seven
bladder cancer
cell lines and eight pairs of malignant/nonmalignant bladder tissues. The role of
GRB7
in tumor proliferation and tumorigenesis was explored by establishing stable cells,
in vitro
cell experiments and
in vivo
xenograft models. The molecular regulation mechanism of
GRB7
in
bladder cancer
was investigated by treatment with AKT inhibitor.
GRB7
mRNA
was upregulated in
bladder cancer
samples compared with that in normal tissue samples. Overexpressing
GRB7
significantly promoted the proliferation and tumorigenesis of
bladder cancer
. However, silencing
GRB7
played the retarding part.
GRB7
promoted G1/S transition by activating the AKT pathway. Our results indicate that
GRB7
plays an important role in promoting proliferation and tumorigenesis of
bladder cancer
.
...
PMID:Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. 3316 27
