Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0005684 (
bladder cancer
)
16,431
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bladder cancer
is among the most common cancers all over the world. The function of
basic leucine zipper and W2 domains 2
(
BZW2
) in tumour progression has been reported. However, the biological function of
BZW2
in muscle-invasive bladder cancers (MIBCs) remains to be determined. The aim of the present study was to reveal the expression and roles of
BZW2
in human MIBCs and to explore the molecular mechanisms underlying these functions. Clinically,
BZW2
expression was higher in MIBC tissues than the adjacent non-tumour tissues. Knocking down
BZW2
using shRNA inhibited cell proliferation and G1/S cell cycle progression in vitro, and induced apoptosis in both 5637 and T24 cells. Moreover, in vivo studies with mice xenograft models confirmed the anti-proliferative effects of
BZW2
-knockdown, providing a future therapeutic target. We also performed biochemical microarray analysis to identify the potential signalling pathways, disease states and functions which could be affected by suppressing
BZW2
in MIBC cells. Collectively, our findings suggest
BZW2
has an oncogenic role in MIBCs and serves as a promising target for molecular diagnosis and gene therapy.
...
PMID:BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: A microarray pathway analysis. 3093 31
