Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004623 (bacterial infection)
 15,226 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the course of a study to determine the nature and type of secondary bacterial infection in dracunculiasis. The most common organisms cultured from lesions were Escherichia coli, Enterobacter and Staphylococcus aureus. E. coli and Enterobacter which were found to carry high morbidity were sensitive to Gentamycin, Claforan and Septrin.
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PMID:Secondary infections in dracunculiasis: bacteria and morbidity. 293 43

43 patients undergoing treatment for acute leukaemia were randomised to receive either co-trimoxazole alone or co-trimoxazole with framycetin and colistin as antibacterial prophylaxis during periods of neutropenia. There were no significant differences between the two treatment groups in the time before the onset of the first fever, the number of episodes of fever or of septicaemia per patient, the number of neutropenic days during which patients remained afebrile or did not require systemic antibiotics, or the number of resistant organisms acquired. Co-trimoxazole alone is cheaper and easier to take than co-trimoxazole with framycetin and colistin, and it is therefore preferable to the three-drug combination for the prophylaxis of bacterial infection.
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PMID:Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukaemia. 611 43

A group of six patients with non-infected synovial effusions requiring diagnostic or therapeutic aspiration, were given a short oral course of 'Septrin' (two tablets bd for two doses, each tablet containing 80 mg of trimethoprim plus 400 mg of sulphamethoxazole). Serum and synovial fluid (SF) were sampled frequently following antibiotic administration. It was found that concentrations of trimethoprim in SF approached serum levels after a short lag time (about 3 h) and thereafter approximated to the serum levels, whereas sulphamethoxazole did not as readily penetrate into SF. With the regimens used MIC levels for trimethoprim were achieved in SF, which suggests that this drug could be usefully prescribed in normal doses for the treatment of septic arthritis due to bacterial infection.
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PMID:The penetration of trimethoprim and sulphamethoxazole into synovial fluid. 660 36

Co-trimoxazole is infrequently prescribed in the UK due to concerns regarding adverse events. However, it has a low association with Clostridium difficile-associated disease (CDAD) and may represent an alternative to higher-risk agents. This retrospective study examines the efficacy and safety of intravenous co-trimoxazole in treatment of bacterial infection in a UK inpatient population of 50 inpatients. Outcome was determined to be successful in 58% of treatment episodes; in hospital-acquired pneumonia the response rate was 52%. Two treatment episodes were terminated due to adverse events: these resolved on discontinuation of co-trimoxazole. No significant change in renal function, evaluated by serum creatinine, was observed during therapy; blood platelet count was not affected by treatment with intravenous co-trimoxazole. One patient developed CDAD within one month of cessation of therapy. Intravenous co-trimoxazole was clinically effective with a low rate of adverse events and may represent a useful alternative antimicrobial agent in UK institutions with high rates of CDAD.
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PMID:Use of intravenous co-trimoxazole to treat bacterial infection: analysis of 50 treatment episodes. 2068 32

Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is prevalent in tropical countries and is intractable to a number of antibiotics. In this study, the antibiotic co-trimoxazole (trimethoprim/sulfamethoxazole) was assessed for the post-exposure prophylaxis of experimental infection in mice with B. pseudomallei and its close phylogenetic relative Burkholderia mallei, the causative agent of glanders. Co-trimoxazole was effective against an inhalational infection with B. pseudomallei or B. mallei. However, oral co-trimoxazole delivered twice daily did not eradicate infection when administered from 6h post exposure for 14 days or 21 days, since infected and antibiotic-treated mice succumbed to infection following relapse or immunosuppression. These data highlight the utility of co-trimoxazole for prophylaxis both of B. pseudomallei and B. mallei and the need for new approaches for the treatment of persistent bacterial infection.
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PMID:Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. 2351 14