Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004610 (bacteremia)
 13,199 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study concerns in vitro observations on the susceptibility to antibiotics and chemotherapeutic agents of the strains of F. meningosepticum isolated from various clinical specimens at the Clinical Laboratory of Juntendo University Hospital and the assessment of their clinical significance of the patient, when they are isolated from clinical specimens. 1) Fifty-two % of the strains was isolated from sputum, 20% from urine and 8% from pus and exudate. Only 2 strains were obtained from blood and one strain from cerebro-spinal fluid. 2) The patients with F. meningosepticum from sputum had respiratory distress due to the basic disorder of central nervous system, respiratory system or cardiovascular system. An endotracheal tube or a tracheal canule was placed in most of the patients to assure a patient airway, and they received massive antibiotic therapy. Most of the patients with infected urine had functional and structural abnormality of the urinary tract, as well as a history of instrumentation, and had previously received antibiotic therapy. The bacteremia due to F. meningosepticum occurred after major operation in 2 patients, and one of them suffered from hydrocephalus associated with meningitis, moreover, in whom the organism was isolated from cerebro-spinal fluid. The route of infection with F. meningosepticum cannot be assessed certainly, but the correlation with catheterization or canulation strongly suggests that the instrumentation is required for the organism to become established. 3) In vitro test for sensitivity to 19 chemotherapeutic agents were done with the strains of F. meningosepticum isolated at the laboratory from August 1974 through July 1976. A large number of the strains were highly resistant to SB-PC, CB-PC, DKB, LCM, CL and NF, and resistant to AB-PC, CEZ and AMK. All strains were highly sensitive to MINO, DOTC and CLDM in this order, and were sensitive to EM, PA and NA. The relative sensitivity was found to TC, CP, GM and PPA.
 ...
PMID:[Clinical and bacteriological study on Flavobacterium meningosepticum (author's transl)]. 85 60

In the early 1980's methicillin-resistant Staphylococcus aureus (MRSA) was reported as a major pathogenic organism of geriatric hospital infection in Japan. At the same time in our geriatric wards, including 190 beds, MRSA infection was prevalent. In the early 1980's in our geriatric wards minocycline was one of the most sensitive antibiotics to MRSA isolated in our wards and used frequently against MRSA pneumonias and bacteremia. In the late 1980's resistant strains of MRSA to minocycline rapidly increased because vancomycin was not allowed to introduced for treatment of MRSA before 1991 in Japan. At the same period the predominant coagulase type changed from type II to type VII. To decrease minocycline-resistant strains to MRSA after 1987, use of minocycline was limited. Moreover since Oct. 1991 to decrease nosocomial infections some active preventive measures against hospital infection, including limited use of 2nd and 3rd cephems, were taken. In this study changing patterns of coagulase type of Staphylococcus aureus were discussed. At least 4 years was needed to find out that the predominant coagulase type changed from type VII to type II again in 1991. In this study about 22 antimicrobial agents MICs of 313 strains of Staphylococcus aureus isolated between March 1992 and June 1993 were determined and compared with the data of MICs before introduction of preventive measures. The pattern of susceptibility to MINO was in part improved. Thus the some sensitive strains of S. aureus were observed again in our geriatric wards. Interestingly indeed it took approximately 5 years to find out the emergence of sensitive strains to MINO since limitation of use of MINO in 1987.
 ...
PMID:[Coagulase typing of Staphylococcus aureus in the geriatric wards after introduction of preventive measures of hospital infection]. 912 7