Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004364 (autoimmune disease)
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Human Gene/Protein
PNMA1 protein 10.3
HLA-DR4 protein 10.3
laminin, beta 4 10.3
rheumatoid arthritis-related antigen RA-A47 10.3
IGHV4-28 10.3
FAM119B 10.3
BING2 10.3
FLJ20035 10.3
membrane-associated nucleic acid binding protein 10.3
LOC63920 10.3
transporter 1 ATP-binding cassette sub-family B 10.3
FLJ11152 10.3
Ig heavy chain V-III region 10.3
Raftlin-2 10.3
testis specific, 10 10.3
Histamine receptor H1 10.3
Aryl hydrocarbon receptor nuclear translocator-like 10.3
ankyrin repeat domain 44 10.3
ZBTB37 10.3
CXorf21 9.9
CD159c 9.3
WFDC3 9.3
raft-linking protein 9.3
KIAA1838 9.3
CHRNA7 protein 9.3
ADAMTS-like protein 5 9.3
BING4 9.3
C10orf64 9.3
ELKL motif kinase 9.3
MHC class II HLA-DRB1 9.3
IAN5 9.3
PRAMEF13 9.3
SAMD3 9.3
CHCHD5 9.3
TTC6 9.3
B-cell scaffold protein with ankyrin repeats 9.3
EIF4E1B 9.3
HLA-DR beta1 9.3
SLED1 9.3
Kelch-like protein 7 9.3
PRIC285 9.3
CHIC1 9.3
voltage-gated calcium channel alpha 1 subunit 9.3
TRIM39R 9.3
kelch-like 12 9.3
C2orf74 8.7
Syntaxin-1B 8.7
ZNF596 8.7
CUZD1 8.7
EP2 prostaglandin receptor 8.7
TCRBV5S2 8.7
hr44 8.7
C6orf208 8.7
BING1 8.7
G6E 8.7
Fc receptor-like 2 8.7
OR8D4 8.7
NFKB3 8.7
D6S60E 8.7
psoriasis susceptibility 1 candidate 1 8.7
ZNF232 8.7
CDC42EP1 8.7
IVNS1ABP 8.7
TRA@ 8.5
PRAP1 8.3
KIAA1542 8.3
SCARF1 8.3
CCL19 protein 8.3
tubulin-specific chaperone A 8.3
RFC1 protein 8.3
Chemokine (C-C motif) ligand 19 8.3
ERBB3 protein 8.3
DNASE1L1 8.3
SPPL2A 8.3
TMEM187 8.3
PTPN22 protein 8.3
RPP38 8.3
chemokine (C-X-C motif) receptor 5 8.3
tubulin beta-5 8.3
Kelch-like protein 12 8.3
more...
Disease
Nasal chondritis 10.3
autoimmune disease 10.3
AITD1 10.3
Cramp-Fasciculation Syndrome 10.3
Deficiency of protease 10.3
Hyperglobulinemic purpura 10.3
Diffuse scleritis 10.3
stage IIB melanoma 10.3
Subacute lymphocytic thyroiditis 9.7
Primary Sjogren's syndrome 9.4
Purpura hemorrhagica 9.3
Respiratory tract chondritis 9.3
Myasthenia gravis associated with thymoma 9.3
Chronic histoplasmosis 9.3
Diarrhea-negative HUS 9.3
Noninfective endocarditis 9.3
Purpura hemorrhagica 9.3
MYAS1 9.3
Childhood lichen sclerosus 9.3
SLEB2 9.3
Generalized vitiligo 9.2
Immune thrombocytopenia 8.8
Chronic idiopathic thrombocytopenic purpura 8.8
Ulcerative stomatitis 8.7
Clostridium colitis 8.7
Interstitial myositis 8.7
SLEH1 8.7
IDDM17 8.7
IDDM18 8.7
Anterior scleritis 8.7
Oral mucous membrane pemphigoid 8.7
Polyradiculoneuritis 8.7
Alopecia universalis 8.6
other autoimmune disease 8.6
Undifferentiated connective tissue disease 8.6
Autoimmune inner ear disease 8.5
IDDM13 8.5
Ocular myasthenia 8.5
Endocrine orbitopathy 8.4
Neonatal lupus erythematosus 8.4
Mycoplasma arthritis 8.3
Genital lichen sclerosus 8.3
Secondary antiphospholipid syndrome 8.3
IDDM6 8.3
Vulvitis circumscripta plasmacellularis 8.3
Neonatal Graves' disease 8.3
Relapsing polychondritis 8.3
Immune thrombocytopenic purpura 8.2
Juvenile dermatomyositis 8.1
Chronic thyroiditis 8.1
IDDM12 8.1
Hughes syndrome 8.0
Cutaneous lupus erythematosus 8.0
Equine recurrent uveitis 8.0
Corneal endotheliitis 8.0
PLSJ 8.0
Myasthenic crisis 7.9
Congenital heart block 7.9
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy 7.9
Pemphigus vulgaris 7.9
Secondary progressive multiple sclerosis 7.9
oophoritis 7.8
Recurrent parotitis 7.7
ophiasis 7.7
IDDM11 7.7
Rheumatoid lung 7.7
Generalized myasthenia 7.7
Autoimmune Addison's disease 7.7
Neuropsychiatric lupus 7.7
Peripheral ulcerative keratitis 7.7
Steroid-induced diabetes 7.7
Idiopathic myocarditis 7.7
Lymphocytic hypophysitis 7.6
Drug-induced hypersensitivity syndrome 7.6
Sjogren's syndrome 7.6
Postpartum thyroiditis 7.6
Acquired hemophilia 7.5
epipharyngitis 7.5
Vegetative endocarditis 7.5
Graves' dermopathy 7.5
more...
Symptom
Neck discomfort 9.3
Nonspecific abdominal pain 9.3
Pustular rash 8.7
Pruritus of pregnancy 8.7
Hearing complaints 8.7
neuromuscular manifestation 8.3
SLE-like symptoms 8.2
Digital necrosis 7.5
Death rattle 7.3
Myokymia 7.1
localized rash 6.9
Sudden deafness 6.2
dry eye 6.0
skin impairment 5.9
neurological disability 5.8
Pyramidal signs 5.7
Beau's lines 5.6
localized edema 5.6
Atypical facial pain 5.5
abnormal taste 5.4
musculoskeletal impairment 5.0
Cushingoid 4.9
onychomadesis 4.9
Cushingoid 4.8
carpopedal spasm 4.8
Neurologic symptoms 4.8
livedo 4.7
swollen joints 4.7
Visual disturbances 4.5
scaly skin 4.5
generalized erythema 4.4
Murphy's sign 4.4
splenomegaly 4.3
arthralgia 4.2
dark urine 4.2
pedal edema 4.2
Psychiatric symptoms 4.0
periorbital edema 3.9
weakness 3.9
Vulvodynia 3.8
dysosmia 3.8
arm weakness 3.8
feeling depressed 3.8
chorea 3.7
Musculoskeletal symptoms 3.6
cardiovascular impairment 3.6
nerve pain 3.6
muscle stiffness 3.5
Visual symptoms 3.5
meningism 3.5
disturbed balance 3.5
polymyalgia 3.5
fever of unknown origin 3.5
Gastrointestinal symptoms 3.5
facial droop 3.3
bladder pain 3.3
photopsia 3.3
hepatosplenomegaly 3.3
ataxic gait 3.2
adenitis 3.2
generalized rash 3.2
pleuritic chest pain 3.1
loss of balance 3.1
dysarthria 3.1
catatonia 3.0
myalgia 3.0
hypalgesia 2.9
joint stiffness 2.9
asthenia 2.9
abdominal cramps 2.9
Flare 2.9
Neuropathic pain 2.9
loss of taste 2.8
intestinal bleeding 2.7
abdominal fullness 2.6
consciousness disturbance 2.6
hand pain 2.6
cerebellar ataxia 2.6
polydipsia 2.5
fatigue 2.5
more...
Drug
Edratide 9.3
Evoxac 8.0
Roquinimex 7.4
Lobenzarit disodium 7.3
Cevimeline 7.3
Epratuzumab 7.1
Belimumab 7.0
Dexamethasone palmitate 7.0
Abatacept 6.8
Iguratimod 6.7
Sarpogrelate hydrochloride 6.6
Cytomel 6.6
BZQ 6.5
Cytomel 6.5
BLyS 6.5
SR 57746A 6.2
Copaxone 6.0
Bindarit 5.8
Betaseron 5.8
Interferon beta 5.7
Lisofylline 5.6
Natalizumab 5.4
Ontak 5.4
Ontak 5.4
Rituximab 5.4
Cellcept 5.3
Cellcept 5.3
Proleukin 5.2
CIA 5.2
Cortisporin 5.2
Daclizumab 5.1
Campath 5.1
Campath 5.1
Prolastin 5.0
Ocrelizumab 5.0
Omniscan 4.9
Synthroid 4.7
Tocilizumab 4.6
EDR 4.6
RPH 4.5
Thyroglobulin 4.5
Efalizumab 4.5
Tetanus toxoid 4.5
Eculizumab 4.5
Efalizumab 4.5
Hyoscyamine 4.3
Japanese encephalitis vaccine 4.2
Mycophenolic acid 4.2
Omniscan 4.2
IFN-gamma 4.2
Avonex 4.2
Prednisone 4.1
IL-2 4.1
Imiquimod 4.1
Adalimumab 4.1
Vesnarinone 4.1
Alefacept 4.1
Adapalene 4.1
Ciglitazone 4.0
Hyoscyamine 4.0
Calcipotriol 4.0
Mepolizumab 4.0
Thymopentin 3.9
Synthroid 3.9
Pegasys 3.8
Immune globulin 3.7
Mizoribine 3.7
Miglustat 3.7
Ipilimumab 3.7
NOV 3.6
Rolipram 3.6
Estriol 3.5
Tacrolimus 3.5
CA-074 3.5
Red ginseng 3.5
Mineral oil 3.4
ISP 3.4
IFN-beta 3.3
Antithymocyte globulin 3.3
Methylprednisolone 3.3
more...
Enzyme
peptidylarginine deiminase 6.1
cholesterol 25-hydroxylase 5.8
thyroid peroxidase 5.8
MGAT 5.6
AICAR transformylase 5.5
GP-I 5.4
steroid 17alpha-hydroxylase 5.4
histidyl-tRNA synthetase 5.3
proteinase-3 5.2
cathepsin S 5.2
STK4 4.9
RPH 4.7
N-acetylglucosaminyltransferase V 4.6
transglutaminase 4.5
carboxypeptidase D 4.4
cathepsin V 4.3
DIPP 4.3
histone-lysine N-methyltransferase 4.3
D-dopachrome tautomerase 4.3
C1 esterase 4.3
21-hydroxylase 4.2
formyltetrahydrofolate synthetase 4.2
glycinamide ribonucleotide transformylase 4.1
TSO 4.1
methylenetetrahydrofolate dehydrogenase 4.1
dihydroxyacetone phosphate acyltransferase 4.0
inositol phosphatase 3.9
heparitinase I 3.9
STK3 3.9
arginine deiminase 3.9
TSP-1 3.8
mannosidase II 3.7
p100 3.7
prolyl-tRNA synthetase 3.7
mutarotase 3.6
glutamate decarboxylase 3.6
bromelin 3.5
thiopurine methyltransferase 3.5
pantetheinase 3.5
GalNAc-T 3.5
granzyme B 3.4
indoleamine 2,3-dioxygenase 3.4
GTI 3.4
DSR 3.4
PPH 3.4
dihydroorotate dehydrogenase 3.4
dihydroorotate dehydrogenase 3.3
bromelain 3.3
PWD 3.3
3'-exonuclease 3.3
DNase II 3.2
factor D 3.1
pyruvate dehydrogenase 3.1
dimethylarginine dimethylaminohydrolase 3.1
MMP-3 3.0
BMT 2.9
matrix metalloproteinase 9 2.9
ScpA 2.9
Thy1 2.9
spermine synthase 2.8
caspase-10 2.8
TSR 2.8
caspase-10 2.8
C3 convertase 2.8
kynureninase 2.8
NQO2 2.7
cathepsin C 2.7
legumain 2.7
branched-chain alpha-keto acid dehydrogenase 2.7
carboxypeptidase E 2.7
C3 convertase 2.6
poly(ADP-ribose) glycohydrolase 2.6
AAE 2.6
PHD 2.6
alanyl-tRNA synthetase 2.6
GRK2 2.6
pyruvate dehydrogenase 2.6
cyclohydrolase 2.6
pyruvate dehydrogenase 2.6
IKK 2.5
more...
Compound
dichloroacetic anhydride 8.7
C6H12N2O 8.0
2-octynoic acid 7.7
Previtamin D3 7.3
PADA 7.3
Ethylestrenol 7.3
Budlein A 7.2
Caerulomycin 7.2
4-methyl-1,3-thiazole 7.2
Cortivazol 7.2
Bufotalin 7.0
Budlein A 6.9
2-azaspiro[4.5]decane 6.7
Polymyxin B sulfate 6.7
10-formyldihydrofolate 6.7
HKP 6.3
V 7 6.3
Fluorometholone 6.2
Complement factor B 6.2
Bisphenol A diglycidyl ether 6.1
Pyridostigmine 6.1
Trinitrobenzenesulfonic acid 6.0
2-Hydroxyglutarate 6.0
Pristane 6.0
CGP 52608 5.9
Mitox 5.9
Micheliolide 5.8
TMAB 5.8
Micheliolide 5.8
Pristimerin 5.6
Pristimerin 5.6
Pristimerin 5.6
Pristimerin 5.6
AMAC 5.6
Queuine 5.6
T undecanoate 5.5
Dimethyl fumarate 5.5
Interferon beta-1b 5.5
3,4-DAP 5.4
5,10-Methylenetetrahydrofolate 5.3
Medicarpin 5.3
Anserine 5.3
NKT 5.2
CCP 5.2
Mycophenolate mofetil 5.2
Leflunomide 5.2
ethyl myristate 5.2
HgCl2 5.1
238A 5.1
ANCA 5.1
Cuprizone 5.0
Hydroxychloroquine 5.0
Fludarabine phosphate 4.9
DQ1 4.9
TNX 4.9
PLP 4.9
Theaflavin 4.8
Deoxyspergualin 4.8
Nafoxidine 4.8
PPBP 4.8
Florid 4.7
Diacetoxyscirpenol 4.7
Sinomenine 4.7
APS 4.7
ANA 4.7
ANA 4.7
Nandrolone decanoate 4.7
Celastrol 4.5
PAPS 4.5
Glycerophosphocholine 4.5
ITP 4.5
Ethyl pyruvate 4.5
Purine nucleoside 4.5
DGI 4.5
Hinokitiol 4.4
Paeoniflorin 4.4
Tuftsin 4.4
Calpeptin 4.4
Ursodeoxycholic acid 4.4
Tumor Necrosis Factor 4.4
more...