Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004364 (autoimmune disease)
 24,845 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cytokine 1860
Sep 1518
CD4 1510
insulin 1049
Mol 935
autoantigen 777
lymphoid 730
HLA 718
CD8 653
IFN 635
thymus 629
collagen 624
interferon 593
IL-10 572
IL-6 548
IL-17 534
TNF 521
MHC 459
major histocompatibility complex 430
IFN-gamma 421
IL-4 413
tumor necrosis factor 392
IL-2 386
TCR 369
CD25 360
myelin basic protein 345
acetylcholine receptor 336
T cell receptor 335
Fas 314
gut 291
lacrimal 289
MHC class II 276
NOD 264
IgA 251
glycoprotein 250
rheumatoid factor 244
She 235
chemokine 227
CD28 220
axonal 216
TNF-alpha 196
human leukocyte antigen 190
interferon-gamma 184
CD20 178
histone 174
CD40 172
Cytokine 171
lipopolysaccharide 163
thyroglobulin 162
CTLA-4 160
HLA-DR 158
myelin oligodendrocyte glycoprotein 149
IgE 149
IL-23 146
IL-1 141
HLA class II 133
B10 131
SSA 130
TGF-beta 123
type I interferon 122
interleukin-6 121
MRI 117
LPS 116
TLR9 115
type II collagen 114
interleukin-2 114
BAFF 113
CD86 113
CD40L 110
MHC class I 106
DR3 104
SS-A 104
C-reactive protein 104
CD80 103
DBA 103
FOXP3 102
glutamic acid decarboxylase 99
proteolipid protein 99
SSB 98
autoimmune regulator 95
TLR4 94
DR4 94
IL-21 90
TLR7 90
CTLA4 90
SS-B 87
CD19 87
STAT3 86
myeloperoxidase 86
Fas ligand 85
ankylosing spondylitis 85
PTPN22 85
B lymphocyte stimulator 84
ANA 84
CD45 83
non-Hodgkin's lymphoma 83
thyroid peroxidase 82
DQ2 81
IgG3 81
X-linked 79
IL-5 79
IL-13 77
thyroid hormone 77
nicotinic acetylcholine receptor 76
microsomal 75
tumor necrosis factor alpha 75
tyrosine kinase 75
RNP 71
lectin 70
endoplasmic reticulum 69
IL-18 69
IL-8 69
HLA-DRB1 69
MAPK 68
polypeptide 68
IDDM 67
CD44 67
T-bet 67
CD5 66
PD-1 66
albumin 66
IL-22 66
GM-CSF 65
interleukin-10 65
CD95 64
Fc receptor 64
CSF 63
interleukin-17 63
mTOR 63
CD11b 63
hemoglobin 63
HLA class I 62
interferon gamma 61
CD1d 61
interleukin-4 61
caspase-3 61
Bcl-2 61
PI3K 60
inducible nitric oxide synthase 59
factor VIII 58
ribonucleoprotein 58
tissue transglutaminase 58
ICAM-1 58
p38 58
GAD65 57
ubiquitin 57
IL-15 57
IL-2 receptor 57
aquaporin-4 57
ATP 57
STAT1 56
HLA-DR3 56
CRP 56
p53 55
adhesion molecule 55
APC 55
FasL 54
TNF receptor 54
phosphatase 54
HLA-DR4 54
more...
Disease
autoimmune disease 24845
systemic lupus erythematosus 4502
rheumatoid arthritis 2618
multiple sclerosis 2140
lupus 1963
diabetes 1739
cancer 1676
lupus 1605
arthritis 1255
encephalomyelitis 1253
type 1 diabetes 1045
myasthenia gravis 824
tumor 689
PSS 653
glomerulonephritis 547
vasculitis 529
Graves' disease 511
thrombocytopenia 472
antiphospholipid syndrome 440
celiac disease 431
Lupus 401
lupus nephritis 389
psoriasis 383
lymphoma 377
Hashimoto's thyroiditis 363
SLE 349
proteinuria 322
infectious diseases 318
immunodeficiency 315
scleroderma 314
virus infection 307
mimicry 275
primary biliary cirrhosis 273
NOD 264
renal disease 261
inflammatory bowel disease 260
hepatitis 259
hypothyroidism 236
nephritis 232
vitiligo 227
hypertension 225
atherosclerosis 224
thyroiditis 223
hyperthyroidism 222
uveitis 221
cardiovascular disease 220
xerostomia 219
pemphigus 218
lymphadenopathy 214
HIV 209
encephalitis 206
Crohn's disease 201
alopecia areata 200
anemia 199
autoimmune thyroid disease 195
dermatomyositis 195
idiopathic thrombocytopenic purpura 194
Sjogren's syndrome 194
autoimmune thyroiditis 186
asthma 185
Epstein 176
graft-versus-host disease 173
rash 152
skin disease 150
obesity 150
leukemia 149
liver disease 143
thrombocytopenic purpura 140
systemic disease 138
pemphigoid 135
cirrhosis 135
hyperglycemia 132
depression 131
interstitial lung disease 130
thymoma 130
polymyositis 130
tuberculosis 129
ulcerative colitis 124
myocarditis 122
immunopathology 121
autoimmune hemolytic anemia 121
sarcoidosis 119
ankylosing spondylitis 119
Immune thrombocytopenia 115
renal failure 115
synovitis 114
connective tissue disease 114
hemolytic anemia 113
myositis 111
colitis 109
Infection 109
Hodgkin's disease 108
hepatitis C 108
carcinoma 107
stroke 107
cytomegalovirus 105
B-cell lymphoma 105
chronic disease 104
DBA 104
neuropathy 104
plaque 102
osteoporosis 102
AIDS 102
sepsis 102
gastritis 101
type 2 diabetes 100
dermatitis 98
melanoma 97
sepsis 97
enteropathy 94
non-Hodgkin's lymphoma 92
pneumonia 92
goiter 91
Syndrome 91
Wegener's granulomatosis 91
Addison's disease 89
hypergammaglobulinemia 89
Pemphigus vulgaris 88
Neuromyelitis optica 87
polyarthritis 87
Addison's disease 86
Graves' ophthalmopathy 85
Best 85
influenza 85
Mycobacterium 85
lymphopenia 84
Alzheimer's disease 84
sialadenitis 83
polyneuropathy 83
pernicious anemia 83
preeclampsia 80
abortion 80
lung disease 80
rare disease 79
mucosa-associated lymphoid tissue 78
encephalopathy 78
cold 78
myasthenia 77
keratoconjunctivitis sicca 77
chronic hepatitis 75
cholangitis 74
infertility 73
Lambert-Eaton myasthenic syndrome 73
purpura 72
breast cancer 72
vitamin D deficiency 72
candidiasis 72
ischemia 71
multiple myeloma 71
lymphoproliferative disorders 70
heart failure 69
Goodpasture's syndrome 69
pruritus 68
pancreatitis 68
Relapsing polychondritis 68
membranous nephropathy 68
cognitive impairment 67
SCID 66
hepatitis B 66
Raynaud's phenomenon 65
more...
Symptom
weakness 434
pain 302
fatigue 234
splenomegaly 152
dry eye 131
seizures 120
diarrhea 113
arthralgia 104
headache 100
abdominal pain 69
dyspnea 67
erythema 52
ataxia 51
cough 47
anesthesia 45
vomiting 42
neurological disability 41
myalgia 40
hepatosplenomegaly 33
nausea 30
chest pain 27
discomfort 26
discomfort 26
dysarthria 25
shortness of breath 23
chorea 22
Ill 22
collapse 21
hemoptysis 21
exhaustion 20
vertigo 19
anorexia 19
myoclonus 19
hepatomegaly 18
sleepiness 18
livedo 18
tremor 18
fever of unknown origin 18
cachexia 17
spasticity 17
numbness 17
cerebellar ataxia 17
insomnia 16
respiratory distress 15
asthenia 15
constipation 15
dizziness 14
chills 13
ophthalmoplegia 13
paresthesia 13
starvation 12
hoarseness 12
agitation 12
memory loss 12
paresis 12
back pain 12
tinnitus 11
swollen joints 11
muscle stiffness 11
polyuria 11
regurgitation 10
dystonia 10
polydipsia 10
angina 10
functional recovery 9
lethargy 9
overweight 9
exertional dyspnea 9
Neuropathic pain 8
nausea and vomiting 8
spasm 7
stridor 7
catatonia 7
neck pain 7
thinning 7
syncope 6
acute stress 6
tense 6
photophobia 6
analgesia 6
acute abdominal pain 6
joint stiffness 6
Cushingoid 5
Gastrointestinal symptoms 5
hypothermia 5
acute abdomen 5
HSA 5
hypotonia 5
blurred vision 5
night sweats 5
oliguria 5
Cushingoid 5
chronic cough 5
cyanosis 5
bloating 5
ENT 5
dark urine 4
Neurologic symptoms 4
Psychiatric symptoms 4
intestinal bleeding 4
pleuritic chest pain 4
low back pain 4
dysesthesia 4
localized edema 4
muscle rigidity 4
consciousness disturbance 4
bradykinesia 4
pallor 4
ataxic gait 4
adenitis 4
decreased appetite 4
clubbing 4
apathy 4
pedal edema 3
scaly skin 3
hunger 3
bladder pain 3
epigastric pain 3
dry skin 3
dysuria 3
otalgia 3
meningism 3
Welt 3
periorbital edema 3
facial pain 3
fasciculation 3
flank pain 3
knee pain 3
pelvic pain 3
loss of balance 3
Myokymia 3
tingling 3
abdominal cramps 3
hypersomnia 3
hemiplegia 2
Beau's lines 2
onychomadesis 2
arm weakness 2
hip pain 2
torticollis 2
rigors 2
productive cough 2
distraction 2
paraparesis 2
wheezing 2
Sudden deafness 2
hypoproteinemia 2
microbial colonization 2
bone pain 2
incoordination 2
tonic-clonic seizure 2
SLE-like symptoms 2
skin damage 2
muscle cramps 2
excessive sweating 2
Visual disturbances 2
abdominal fullness 2
eds 2
flushing 2
halitosis 2
more...
Drug
Dermatol 597
IFN-gamma 411
IL-2 389
CSF 124
Rituximab 94
Asthma 67
lysine 46
Cardiovasc 43
CTX 33
ROC 32
ROS 24
IFN-beta 24
CIA 23
Campath 20
Campath 20
Dial 19
ascorbate 18
Abatacept 17
Copaxone 16
MAP 15
Tacrolimus 15
Asn 15
Estrogens 14
BLyS 14
Prednisone 14
Natalizumab 13
Bifidobacterium 12
vitamin E 12
p75 11
Nitric Oxide 11
ENT 11
Monit 11
DNase I 10
Prednisolone 10
Belimumab 10
G-CSF 9
Nephron 9
IL-1ra 9
Histamine 9
Gel 9
Thyroglobulin 9
Infliximab 8
Spectrum 8
Infliximab 8
Tocilizumab 8
Albumin 8
Adalimumab 7
Methylprednisolone 7
lactose 7
Imiquimod 7
Nephron 7
CCL 7
DM1 6
ABC 6
CTX 6
EDR 6
Spectrum 6
Leaf 6
Interferon beta 6
CTX 6
Eculizumab 6
Retinoic acid 6
EE2 5
EPA 5
PDL 5
Biopolymers 5
Vitamin B12 5
ALA 5
Alliance 5
Daclizumab 5
Mycophenolic acid 5
Epratuzumab 4
NaI 4
caffeine 4
BCG vaccine 4
Bortezomib 4
Ipilimumab 4
nitroglycerin 4
ISP 4
CFS 4
IL-11 4
Betaseron 4
Rolipram 4
CAM 4
ampicillin 4
ETS 4
Imatinib 4
Tetanus toxoid 3
Glutathione 3
MDS 3
NaI 3
Gleevec 3
DEX 3
PTH 3
ICI 3
NaI 3
Fragment 3
NaI 3
Silica 3
Adenosine deaminase 3
Neoral 3
Indomethacin 3
Cevimeline 3
-deoxyadenosine 3
Vitamin A 3
Emodin 2
GEO 2
Ginseng 2
DEL 2
Phosphatidylserine 2
Ontak 2
LMWH 2
Diphenhydramine 2
Alanine 2
Pilocarpine 2
NADH 2
TAK 2
Emodin 2
Fludarabine 2
DDAVP 2
Activin 2
Doxycycline 2
NOV 2
Calcipotriol 2
Ontak 2
Bosentan 2
Portal 2
Angiotensin II 2
Aminoguanidine 2
Heme 2
Efalizumab 2
Avonex 2
Adriamycin 2
Captopril 2
PTC 2
Arsenic trioxide 2
Roquinimex 2
Lovastatin 2
Bosentan 2
TAT 2
Iguratimod 2
ETA 2
Estriol 2
ADM 2
Vitamin E 2
Iloprost 2
Artesunate 2
Efalizumab 2
DDAVP 2
Omniscan 2
Lenalidomide 2
Omniscan 2
DPA 1
CTC 1
Cortisporin 1
Dasatinib 1
Magnevist 1
Lobenzarit disodium 1
Galactose 1
Thymopentin 1
more...
Enzyme
mitogen-activated protein kinase 171
thyroid peroxidase 133
focal adhesion kinase 130
peroxidase 120
ERK 102
transglutaminase 85
protein kinase 74
APC 72
proteasome 51
calcineurin 50
luciferase 49
caspase-3 48
acetylcholinesterase 47
thromboplastin 47
superoxide dismutase 42
ATPase 40
pyruvate dehydrogenase 37
thrombin 37
catalase 37
alanine aminotransferase 32
lactate dehydrogenase 32
reverse transcriptase 31
alkaline phosphatase 30
RNase 29
ACE 29
RNase 28
ACS 28
granzyme B 28
creatine kinase 27
trypsin 26
cholinesterase 26
lysozyme 25
protein kinase C 25
NADPH oxidase 24
renin 24
NADPH oxidase 24
RNA polymerase 24
aspartate aminotransferase 23
collagenase 23
IKK 22
caspase-1 21
MMP-3 21
phosphodiesterase 21
NO synthase 20
glutamate decarboxylase 20
DNase 19
peptidylarginine deiminase 19
caspase-8 18
phosphoinositide 3-kinase 17
21-hydroxylase 17
pyruvate dehydrogenase 16
BMT 16
tyrosinase 16
pyruvate dehydrogenase 16
MIP 15
cathepsin S 14
CD10 13
glutathione S-transferase 13
matrix metalloproteinase 9 13
glutathione peroxidase 12
indoleamine 2,3-dioxygenase 12
PARP 11
beta-galactosidase 11
neutrophil elastase 11
MEK 10
proteinase-3 10
heme oxygenase 10
phosphatidylinositol 3-kinase 10
topoisomerase 10
topoisomerase 10
arginine deiminase 10
gamma-glutamyl transpeptidase 10
phospholipase A2 9
p100 9
TSP-1 9
pepsin 9
AST 9
phospholipase C 9
endonuclease 9
ceruloplasmin 9
transcriptase 8
bromelain 8
P-glycoprotein 8
adenylate cyclase 8
neuraminidase 8
adenosine deaminase 8
MAP 8
DCF 8
kallikrein 8
elastase 8
CDR 7
plasmin 7
tissue plasminogen activator 7
adenosine deaminase 7
Thy1 7
phosphoglucose isomerase 7
ricin 7
lipase 7
MMP 7
DNA methyltransferase 6
tryptase 6
cathepsin B 6
enolase 6
demethylase 6
caspase-9 6
histidyl-tRNA synthetase 6
NOS 6
cathepsin D 5
sialyltransferase 5
AMP-activated protein kinase 5
TdT 5
papain 5
NQO1 5
urokinase-type plasminogen activator 5
sialyltransferase 5
histone acetyltransferase 5
sialyltransferase 5
thiopurine methyltransferase 5
succinate dehydrogenase 5
xanthine oxidase 5
PAH 5
triphosphatase 5
arginase 5
C3 convertase 5
C3 convertase 5
chaperonin 4
mannosidase II 4
cathepsin L 4
CEP 4
PHD 4
carbonic anhydrase 4
CD13 4
dihydroorotate dehydrogenase 4
dihydroorotate dehydrogenase 4
15-lipoxygenase 4
inositol phosphatase 4
citrate synthase 4
GRK2 4
PDK1 4
lipoxygenase 4
aldolase 4
PTPase 3
cathepsin K 3
protein phosphatase 2A 3
deaminase 3
hexosaminidase 3
ribonuclease 3
GCA 3
kinesin 3
GAS 3
glutathione reductase 3
furin 3
MDP 3
alpha-ketoglutarate dehydrogenase 3
beta-glucuronidase 3
deoxyribonuclease 3
hyaluronidase 3
methionine synthase 3
glyceraldehyde-3-phosphate dehydrogenase 3
acid phosphatase 3
more...
Compound
Clin 2692
Dec 1753
DNA 1509
TNF 521
calcium 293
glucose 252
oxygen 223
vitamin D 196
TSH 130
tyrosine 129
Thyroid 124
water 123
phosphate 122
nitric oxide 111
acetate 111
iodine 105
DBA 103
DBA 102
DBA 102
sodium 99
arginine 98
His 93
creatinine 87
ANA 86
ANA 86
lysine 77
iron 77
NKT 74
mercury 73
sulfate 67
Insulin 66
Vitamin D 61
nitrogen 59
HgCl2 59
tryptophan 57
ATP 57
leucine 57
tryptophan 56
tryptophan 54
tryptophan 54
potassium 52
BCR 51
Cardiol 50
alanine 50
Cyclosporine 49
Collagen 49
urea 49
ANCA 49
cysteine 49
CCP 47
salt 46
zinc 46
serine 46
cAMP 44
APS 43
Methotrexate 43
FK506 41
retinoic acid 40
galactose 38
PLP 38
Phe 36
ITP 36
PEG 34
hydrogen 34
CTX 33
Asp 30
SDS 29
ACS 28
ACS 28
glutamate 28
bromide 27
glutamine 27
ACTH 26
GM1 26
PMA 25
proline 24
methionine 24
Estrogen 24
Estrogen 23
GSH 23
Pac 23
GSH 23
THP 21
CO2 21
threonine 21
MTT 21
aldosterone 21
PEG 20
Dial 19
TOF 19
copper 19
PGE2 19
AMP 19
PMA 18
GABA 18
selenium 18
Optimal 18
hyaluronic acid 17
Mycophenolate mofetil 17
GABA 17
THP 17
Gly 16
ASA 16
PGE 16
NMDA 16
cGMP 16
Interleukin-2 15
aspartic acid 15
ADP 15
ACh 15
ammonium 15
silver 15
STZ 15
glutamic acid 15
Prednisone 15
Ile 14
Tumor Necrosis Factor 14
GTP 14
NH2 14
homocysteine 14
nicotinamide 14
pyrimidine 14
pyrimidine 14
aspartic acid 13
Diabetol 13
H2O2 13
Diabetol 13
Histone 13
aluminum 13
Melatonin 12
ADP 12
BMC 12
DHA 12
MTX 12
Hydroxychloroquine 12
neopterin 12
A 42 12
asparagine 12
Hearts 12
ADP 12
aspartic acid 12
DNP 12
aspartic acid 12
MAP 11
Sphingosine 11
glycerol 11
fluorine 11
Rapamycin 11
BCG 10
Ursodeoxycholic acid 10
Cbl 10
DSS 10
Prednisolone 10
benzene 10
celastrol 10
vinyl 10
TAP 10
EDTA 10
thioglycollate 10
quinoline 10
more...