Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1930
Mol 1695
ASD 1093
Rett syndrome 430
oxytocin 411
MRI 407
gut 394
ADHD 364
GABA 308
X-linked 241
mTOR 185
FMR1 183
TGF-beta 183
FMRP 180
cytokine 161
olfactory 152
brain-derived neurotrophic factor 148
axonal 147
ICD 146
SHANK3 140
MECP2 137
fragile X mental retardation protein 129
parvalbumin 122
Shank3 116
metabotropic glutamate receptor 114
histone 111
oxytocin receptor 106
serotonin transporter 105
NMDA receptor 102
CA1 97
TSC2 97
TSC1 97
vasopressin 94
PTEN 91
Reelin 88
UBE3A 83
NRXN1 75
lipopolysaccharide 72
APA 69
SHANK2 69
CNTNAP2 68
reserved 67
IL-6 65
5-HTTLPR 61
RNA-binding protein 61
CHAT 60
PSD-95 58
casein 58
insulin 56
SRS 56
ATP 55
catenin 55
amyloid precursor protein 55
endoplasmic reticulum 54
TNF 54
She 53
secretin 53
cage 53
NLGN4X 52
glutamate receptor 52
mGluR5 51
ubiquitin 50
CHD8 49
FISH 49
CARS 48
X-chromosome 47
ANOVA 46
Pol 46
ABC 45
PI3K 45
UTR 45
CA3 45
ionotropic 43
MRS 43
HBA 43
phosphatase 42
glial fibrillary acidic protein 42
membrane glycoprotein 41
AKT 40
MET 40
SLC6A4 39
FOXP2 39
5-hydroxytryptamine 38
tap 38
arginine vasopressin 37
NLGN3 37
ERK 37
histone deacetylase 36
GTPase 36
Gen 36
GABRB3 36
MMR 35
L-type calcium channel 35
MAPK 35
tumor necrosis factor 34
receptor tyrosine kinase 33
ubiquitin ligase 33
SERT 33
MIM 33
adhesion molecule 33
ERP 33
San 32
CD4 32
Shank2 32
interleukin-6 32
GSH 32
CACNA1C 32
alternatively spliced 32
Rho 31
somatostatin 31
superoxide dismutase 31
p11 31
ACS 31
CD38 31
GRIN2B 30
phosphatase and tensin homolog 30
nicotinic acetylcholine receptor 29
EN2 29
Mem 29
Mot 29
neurotrophin 29
CHRNA7 29
dopamine transporter 29
CYFIP1 28
transcriptional repressor 28
B12 28
glutamic acid decarboxylase 28
RNA binding protein 28
Fragile X Mental Retardation Protein 28
leptin 28
N-acetylaspartate 27
glycoprotein 27
CDT 27
tuberin 27
p53 27
histone H3 26
Caspr2 26
cell adhesion molecule 26
E3 ubiquitin ligase 26
P300 26
cryptic 26
NKCC1 26
chemokine 25
FOXP1 25
tyrosine hydroxylase 25
methyl-CpG binding protein 2 25
IL-10 24
Met 24
ERK1 24
PHD domain 24
hemoglobin 24
threonine 24
5-HT2A 24
myelin basic protein 24
neurofibromatosis 24
IL-17 24
MEG 23
CSF 23
SHANK1 23
strabismus 23
more...
Disease
autism 32579
Autism 13660
schizophrenia 2829
Disorder 1486
epilepsy 1391
depression 1265
atrial septal defect 1097
Autism spectrum disorder 1066
mental retardation 1026
mental retardation 986
Asperger syndrome 928
ADHD 922
developmental disabilities 880
fragile X syndrome 834
developmental delay 670
Alzheimer's disease 654
bipolar disorder 570
PDD 552
mental illness 503
Rett syndrome 472
psychosis 442
aggression 407
Down syndrome 398
cognitive impairment 351
anxiety disorders 344
obsessive-compulsive disorder 295
obesity 291
Parkinson's disease 290
cancer 280
tuberous sclerosis 274
major depressive disorder 251
cerebral palsy 232
Tourette syndrome 205
dementia 194
diabetes 192
dyslexia 182
macrocephaly 175
genetic disorder 164
Williams syndrome 157
malnutrition 152
multiple sclerosis 150
Angelman syndrome 150
ICD 146
stereotypies 143
sleep disorders 129
posttraumatic stress disorder 126
asthma 125
learning disability 124
tumor 123
stroke 122
self-injurious behavior 119
encephalopathy 118
addiction 112
measles 110
rubella 109
Syndrome 109
neurological disease 104
language disorder 98
mumps 93
sleep disturbances 92
specific language impairment 89
conduct disorder 86
APL 86
tic 85
anorexia nervosa 84
amyotrophic lateral sclerosis 83
HCG 82
intellectual impairment 78
Huntington's disease 77
attention deficit disorder 77
affective disorder 74
migraine 74
cognitive deficit 66
West 66
oppositional defiant disorder 65
psychopathy 65
apraxia 64
fits 63
severe mental retardation 60
social phobia 59
suicide 58
brain dysfunction 58
virus infection 57
confusion 57
prematurity 57
communication disorder 56
SRS 56
deafness 55
substance abuse 55
HFA 55
hypertension 54
infectious diseases 54
hallucinations 54
echolalia 53
inflammatory bowel disease 53
influenza 53
blindness 52
developmental language disorder 52
alcoholism 51
delusions 51
Cerebellum 50
illusion 49
dysplasia 47
Turner syndrome 47
violence 46
perseveration 46
vitamin D deficiency 46
Sleep disturbance 44
mimicry 44
mania 43
MRS 43
cardiovascular disease 43
heart disease 42
celiac disease 42
dysphoria 42
cold 42
developmental coordination disorder 41
behavior disorder 41
aphasia 40
profound mental retardation 39
psychological distress 39
Brown 38
irritable bowel syndrome 37
autoimmune disease 37
encephalitis 37
hamartoma 37
emotionality 37
compulsion 36
parkinsonism 35
neurofibromatosis type 1 35
psychiatric diagnosis 34
chronic pain 34
drug addiction 34
phenylketonuria 33
hypogonadotropic hypogonadism 33
infertility 33
SMS 33
GSH 32
brain disorder 32
borderline personality disorder 32
behavior problem 32
low IQ 32
eating disorder 32
substance use 32
aggressiveness 31
delayed speech 31
mild mental retardation 31
memory impairment 31
leukemia 30
Crohn's disease 30
neuroblastoma 30
mutism 30
metabolic syndrome 29
childhood schizophrenia 29
CBCL 29
Landau-Kleffner syndrome 28
type 2 diabetes 28
moderate mental retardation 27
breast cancer 26
separation anxiety 26
more...
Symptom
seizures 864
pain 242
hypotonia 191
ataxia 162
stigma 111
insomnia 72
weakness 68
alexithymia 67
overweight 66
catatonia 63
tremor 62
constipation 54
agitation 53
anesthesia 48
diarrhea 48
thinning 43
discomfort 42
lethargy 39
sleepiness 38
fatigue 37
dystonia 35
vomiting 31
discomfort 29
enuresis 26
anorexia 26
headache 23
spasticity 23
clumsiness 22
cerebellar ataxia 22
distraction 21
abdominal pain 21
apathy 15
hyperacusis 14
nausea 13
delayed language development 13
chronic constipation 12
exhaustion 12
masculinization 11
Depressive symptoms 11
acute stress 10
tinnitus 10
Gastrointestinal symptoms 10
starvation 10
hemiplegia 9
hunger 9
collapse 9
tense 9
polydipsia 9
myoclonus 9
Behavioral symptoms 9
chorea 8
physical appearance 8
hypothermia 8
impaired motor coordination 8
respiratory distress 7
cough 7
analgesia 7
fasciculation 7
abnormal gait 6
wheezing 6
dysarthria 6
hypertonia 6
muscle rigidity 6
Ill 6
Stepping 5
bloating 5
despair 5
decreased appetite 5
asthenia 4
incoordination 4
dry eye 4
Hudson 4
ataxic gait 4
spasm 4
colic 4
functional recovery 4
syncope 4
myalgia 4
drooling 4
hepatomegaly 4
polyuria 4
arthralgia 4
hopelessness 4
Mannerisms 3
nausea and vomiting 3
memory loss 3
Mills 3
snoring 3
numbness 3
bone pain 3
Sedation 3
hyperemesis gravidarum 3
partial seizure 3
Poor sleep 3
microbial colonization 3
bedwetting 3
torticollis 3
hypersomnia 3
blackout 2
waxy flexibility 2
auditory hallucination 2
erythema 2
Spots 2
back pain 2
prominent nose 2
flushing 2
Ataxic 2
acute pain 2
Motor dysfunction 2
ENT 2
limb pain 2
Functional constipation 2
paraparesis 2
Catch 2
general problem 2
photophobia 2
chromosome marker 2
Joint hypermobility 2
intention tremor 2
Decreased activity 2
Psychiatric symptoms 2
cyanosis 2
loss of balance 2
dizziness 2
motor symptom 2
hepatosplenomegaly 2
dental pain 2
rhinorrhea 2
twitching 2
Physical findings 2
hot flashes 2
tachypnea 2
bradykinesia 1
sciatica 1
joint stiffness 1
Fluctuation 1
Neuropathic pain 1
Involuntary Movement 1
blurred vision 1
facial pain 1
consciousness disturbance 1
hyperoxia 1
Halo 1
disturbed balance 1
Positive and Negative Symptoms 1
Psychotic Symptoms 1
acute abdomen 1
vertigo 1
Wind 1
Multimorbidity 1
abdominal cramps 1
orofacial pain 1
Crawling 1
sneezing 1
cachexia 1
rigors 1
Nasal discomfort 1
neck pain 1
dysesthesia 1
splenomegaly 1
more...
Drug
Spectrum 1734
Spectrum 1734
lysine 57
ABC 45
CSF 26
ROC 24
Secretin 20
ascorbate 19
TMS 17
Portal 16
vitamin E 15
Frontal 14
Bifidobacterium 14
Leaf 13
Dermatol 11
IL-2 11
Glutathione 10
EPA 10
Alliance 10
Monit 9
Check 9
Android 8
Bumetanide 7
niacin 7
THF 7
MAP 7
Nephron 6
CAM 6
Atomoxetine 6
Clonidine 6
GEO 5
Vitamin B12 5
caffeine 5
DM1 5
Asthma 5
Posture 5
p75 4
Diurnal 4
EPI 4
Retinoic acid 4
Triclosan 4
PCP 4
AGG 4
Syntocinon 4
DEL 4
Donepezil 4
Histamine 4
Isotretinoin 4
HCH 4
TAT 4
Sodium valproate 4
MRC 4
BH4 4
Vitamin B 4
ENT 4
DNase I 4
Retinoic Acid 4
CDP 3
Vitamin A 3
NADH 3
PCB 3
Phosphatidylserine 3
Everolimus 3
ALA 3
ROS 3
Cantor 3
Paxil 2
TAC 2
Cardiovasc 2
Ethanol 2
Infliximab 2
TTC 2
IFN-gamma 2
Meconium 2
AMC 2
Parkin 2
Albumin 2
PPA 2
Mutagen 2
Ranitidine 2
Growth hormone 2
Itraconazole 2
Valproic Acid 2
DHT 2
CPO 2
Augmentin 2
citric acid 2
Paxil 2
Sinemet 2
Augmentin 2
ETS 2
uPA 2
Paxil 2
lactose 2
Camp 2
DHT 2
Pronase 2
pyridoxal phosphate 2
DPA 2
Parkin 2
Propofol 2
Growth hormone 2
9-THC 2
ACT 2
Tao 2
Azithromycin 2
Gastro 1
RFP 1
Xanthium 1
Rimonabant 1
Riboflavin 1
Tranxene 1
Amoxicillin 1
Prozac 1
Vitamin K 1
CPR 1
Infliximab 1
Herceptin 1
AZT 1
Fluvoxamine maleate 1
Rituximab 1
Liraglutide 1
Glycerol 1
Japanese encephalitis vaccine 1
Orphan 1
CSI 1
Exenatide 1
CED 1
Tetanus toxoid 1
FAD 1
Fluconazole 1
Daclizumab 1
APD 1
Aricept 1
Scopolamine 1
CTX 1
Acamprosate 1
Calcifediol 1
Pepstatin 1
Zoloft 1
Myotrophin 1
Carbidopa 1
Estrogens 1
Serum albumin 1
Sulpiride 1
Mellaril 1
Leucovorin 1
Ganaxolone 1
Misoprostol 1
Asn 1
DMSA 1
EDR 1
-deoxyadenosine 1
Hypaque 1
Anafranil 1
Ginseng 1
VCR 1
Nitric Oxide 1
Clopidogrel 1
Bayer 1
more...
Enzyme
NOS 131
ERK 111
mitogen-activated protein kinase 93
protein kinase 59
superoxide dismutase 36
ACS 31
luciferase 28
catalase 27
acetylcholinesterase 26
tyrosine hydroxylase 25
proteasome 24
ATPase 22
focal adhesion kinase 20
protein kinase C 20
glutathione peroxidase 19
calcineurin 18
CaMKII 17
complex I 16
phosphatidylinositol 3-kinase 16
monoamine oxidase 15
caspase-3 15
creatine kinase 14
topoisomerase 13
topoisomerase 13
cholinesterase 12
RNA polymerase 11
glutathione S-transferase 11
adenylosuccinate lyase 11
ceruloplasmin 10
phosphoinositide 3-kinase 10
methylenetetrahydrofolate reductase 9
paraoxonase 9
MEK 9
methylenetetrahydrofolate reductase 9
protein phosphatase 2A 9
DAT 8
paraoxonase 8
peroxidase 8
methionine synthase 8
methionine synthase 8
MAP 7
cytochrome oxidase 7
phospholipase A2 7
DNA methyltransferase 6
alpha-amylase 6
phosphodiesterase 6
AOR 6
adenosine deaminase 6
adenosine deaminase 6
tryptophan hydroxylase 6
GSK 6
choline acetyltransferase 6
histone demethylase 6
NADPH oxidase 5
adenylate cyclase 5
glutathione reductase 5
NADPH oxidase 5
NPL 5
NAO 5
ubiquitin-protein ligase 5
urokinase-type plasminogen activator 5
alkaline phosphatase 5
Protein 2 5
MIP 5
succinic semialdehyde dehydrogenase 5
succinate dehydrogenase 4
TAT 4
SST 4
phospholipase C 4
endonuclease 4
guanidinoacetate methyltransferase 4
citrate synthase 4
E-2 4
alanine aminotransferase 4
AMPK 4
demethylase 4
CFI 4
AMPK 4
glutamate decarboxylase 4
kinesin 4
AMP-activated protein kinase 4
CPT 4
ACE 4
STR 4
tissue plasminogen activator 4
dihydropyrimidine dehydrogenase 4
CPT 4
dihydropyrimidine dehydrogenase 4
diacylglycerol kinase 4
NO synthase 4
CPT 4
PCP 4
alcohol dehydrogenase 3
lipoprotein lipase 3
lipase 3
thyroid peroxidase 3
dipeptidyl peptidase IV 3
aspartate aminotransferase 3
histone acetyltransferase 3
thrombin 3
prostate-specific membrane antigen 3
lactate dehydrogenase 3
GCA 3
acetylserotonin O-methyltransferase 3
APC 3
CEP 3
oxytocinase 3
Alternating 3
glycine amidinotransferase 3
arylsulfatase 3
transketolase 3
transcriptase 3
lactase 3
CEP 2
DOPA decarboxylase 2
xanthine oxidase 2
thioredoxin reductase 2
SNO 2
GTP cyclohydrolase I 2
matrix metalloproteinase 9 2
histidine decarboxylase 2
neutrophil elastase 2
propionyl-CoA carboxylase 2
lactonase 2
cathepsin D 2
isocitrate dehydrogenase 2
indoleamine 2,3-dioxygenase 2
DNA ligase 2
PRT 2
GRK5 2
CAD 2
CAD 2
biotinidase 2
monoacylglycerol lipase 2
PAM 2
phenylalanine hydroxylase 2
alpha-glucosidase 2
aldehyde dehydrogenase 2
pyruvate dehydrogenase 2
cdc2 2
transglutaminase 2
MEKK1 2
pyruvate kinase 2
DNA ligase 2
myrosinase 2
trypsin 2
propionyl-CoA carboxylase 2
GABA transaminase 2
HDR 2
pyruvate dehydrogenase 2
tyrosinase 2
Mg2+-ATPase 2
pyruvate dehydrogenase 2
gamma-glutamylcysteine synthetase 2
FAST 2
branched-chain alpha-keto acid dehydrogenase 2
ATP synthase 2
furin 2
carbonic anhydrase 2
triphosphatase 2
more...
Compound
Dec 1999
Clin 992
DSM 686
DNA 655
glutamate 343
GABA 320
GABA 311
calcium 251
5-HT 228
water 188
mercury 160
Cereb 135
Oxytocin 133
oxygen 122
Retard 111
sodium 104
NMDA 98
AMPA 94
methionine 91
vitamin D 89
gamma-aminobutyric acid 88
tryptophan 85
His 84
tryptophan 83
tryptophan 78
tryptophan 78
Neuronal 77
zinc 76
Valproic acid 74
glucose 64
lysine 61
potassium 59
iron 56
ATP 55
tyrosine 55
TNF 54
HFA 54
6-12 48
serine 46
arginine 43
homocysteine 43
sulfate 42
Risperidone 42
cysteine 40
GSH 39
GSH 39
Vitamin D 39
nitric oxide 39
propionic acid 38
propionic acid 38
copper 38
leucine 37
Glutamate 35
glutamine 34
phosphate 33
ethanol 33
aluminum 33
ACS 31
ACS 31
cAMP 29
threonine 29
Valproic acid 29
SET 29
N-acetylaspartate 28
cadmium 27
Dopamine 26
Poly I 24
Aripiprazole 23
alanine 22
ABA 22
hydrogen 22
ABA 22
retinoic acid 21
Melatonin 21
Secretin 20
manganese 20
Diazepam 20
butyric acid 19
creatinine 19
ASC 19
selenium 19
noradrenaline 19
acetate 18
nitrogen 18
PEP 17
butyric acid 17
proline 17
Ile 17
Creatine 16
ammonia 16
TDT 16
PGA 16
GTP 16
folinic acid 16
N-acetylcysteine 16
hydroxyindoleacetic acid 16
adenosylmethionine 16
GSSG 15
Optimal 15
Hearts 15
butyric acid 15
Thyroid 15
Propionate 14
Gly 14
salt 13
Phe 13
AMP 13
iodine 13
ACTH 13
glutamic acid 13
DHA 13
nicotinamide 12
MAOA 12
phosphocreatine 12
A 3 12
SDS 12
acetic acid 12
Insulin 12
Vasopressin 11
urea 11
LTD 11
CCC 11
Cardiol 11
PAS 11
CCC 11
Pac 11
Rapamycin 11
Wellcome 11
BAP 11
isoxazole 11
Neo 10
ADP 10
ADP 10
ADP 10
Fenfluramine 10
aspartic acid 10
EPA 10
Asp 10
galactose 10
silver 9
Cortisol 9
phosphorus 9
ornithine 9
ornithine 9
Resveratrol 9
BMC 9
DBA 9
HVA 9
ornithine 9
ornithine 9
ornithine 9
COS 9
retinol 9
pyridine 9
asparagine 9
DBA 9
valine 9
DBA 9
pyrimidine 9
THE 9
more...