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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The feral children literature has frequently been cited for relevance to understanding historical antecedents of autism. Kaspar Hauser, who appeared in Nuremberg, Germany in 1828, is one of these children, raised under conditions of extreme deprivation. His case history and gradual acquisition of language after age 17 years are summarized. There is strong evidence that he was the prince of Baden, abducted from his cradle in 1812. Findings of postmortem examination, conducted after his assassination, are discussed. Hauser's postadolescent recovery of language contradicts the notion of a "critical period" for language development.
J Autism Child Schizophr 1978 Jun
PMID:Kaspar Hauser's recovery and autopsy: a perspective on neurological and sociological requirements for language development. 35 24

A 10-year-old boy first showed features of infantile autism at age 24 months. Histidinemia was also diagnosed, with histidine blood levels seven times higher than the upper normal values. If the coexistence of autism and histidinemia was not coincidental, histidinemia may have constituted a necessary but not sufficient factor leading to the clinical condition of autism. Other members of the patient's family had high blood levels of histidine, but did not show symptoms that have been related to histidinemia.
J Autism Dev Disord 1979 Mar
PMID:Histidinemia and infantile autism. 43 13

This case study presents long-term follow-up data on Clarence, one of Kanner's original cases of infantile autism. Clarence's attempts to establish a heterosexual relationship and his plans for marriage are described. His success is attributed in part to therapeutic intervention, which was directed at promoting affective responsiveness in the patient. The case of Clarence is seen as lending support to the thesis of DesLauriers and Carlson (1969), who maintain that the core problem in infantile autism is a disturbance of affective contact.
J Autism Child Schizophr 1978 Jun
PMID:The cognitive--affective dilemma in early infantile autism: the case of Clarence. 67 Jan 32

The Bell and Howell Language Master was used in conjunction with the Monterey Language Program to modify the verbal expression of a nine-year-old boy with autistic behaviors. The goal was to train the child to correctly name up to 10 pictures presented individually. Two training modes were used. For one, the therapist spoke at the time (live voice). For the other, she presented a tape recording of her voice via a Language Master. The results suggested that the child's responses to the Language Master were as good as, if not better than, his responses to the live-voice presentations. In addition, observation indicated that he responded more readily to the Language Master presentations. His spontaneous speech was also noted by independent observers to improve in his classroom and in his home. Possible reasons for the improvement in verbal expression are considered.
J Autism Child Schizophr 1975 Jun
PMID:Modifying the verbal expression of a child with autistic behaviors. 117 17

Burack (this issue) reopens questions first raised by my 1989a article in this Journal, on whether children with autism have a specific delay in the development of a theory of mind, or whether the data reflect deviance rather than delay. His paper is of considerable value in highlighting points for debate. In my response, I focus on three issues: First, the logical possibility that delay and deviance can occur together. Second, the evidence that autism may instantiate this possibility. Finally, the important question of the modularity of theory of mind.
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PMID:Debate and argument: on modularity and development in autism: a reply to Burack. 137 20

Leo Kanner headed the first child psychiatry division within a pediatric hospital at Johns Hopkins University. In 1935 he wrote the first book in English of child psychiatry which is still in print. His writings include both organic and environmental etiologies. He was an idealist, and he fought for liberal causes and emphasized an humanitarian approach in dealing with autistic children.
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PMID:Leo Kanner (1894-1981): the man and the scientist. 220 18

The developmental history of a 14-year-old male with Klinefelter's syndrome (XXXXY) is described. A review of the XXXXY literature focuses on the physical complications and the mental deficiency associated with this syndrome. This case study describes an individual whose physical development is consistent with many patterns described in the XXXXY literature, although his retardation is not as severe as generally described. His personality and learning style are more similar to descriptions of XXY Klinefelter individuals. A detailed analysis of more XXXXY cases is essential to clarify developmental patterns and learning capacity in individuals with XXXXY syndrome. Severe retardation may no longer need to be the anticipated developmental outcome.
J Autism Dev Disord 1988 Sep
PMID:Brief report: a case study of an adolescent male with XXXXY Klinefelter's syndrome. 317 Apr 60

Katz (1978) has suggested that mild, fluctuating conductive hearing loss due to middle-ear anomalies may account for the language and attention problems of learning-disabled children. His position was extended here to include autism. Normal, learning-disabled, and autistic children received repeated impedance measures over 5 weeks. A repeated-measures ANOVA of central tendency and variability values led to the conclusions that (1) fluctuating, negative middle-ear pressure greater than normal characterizes both autistic and learning-disabled children, (2) the negative pressure is greater in autistic than in learning-disabled children, and (3) the condition is typically bilateral for autistic children.
J Autism Dev Disord 1988 Mar
PMID:Conductive hearing loss in autistic, learning-disabled, and normal children. 337 59

This is a case study of a left-handed, preschool boy of superior intelligence who read very early and at a level well beyond what his IQ would predict. He is developmentally normal with no signs of autism or related disorders. His reading age was 9.3 at age 2-11 and 11.2 at 4-2; these levels are considerably beyond what would be predicted by his IQ or language age. He was able to read nonwords and both regular and irregular words equally well, indicating his mechanisms of lexical access in reading are similar to those of normal readers. Unlike classical hyperlexics, his reading comprehension for both single words and sentences was well above age level. When his precocious reading first appeared, he was also advanced in reading-related linguistic skills, such as phoneme awareness, auditory verbal short-term memory, and word retrieval, but not in visuospatial skills. These results imply that neither pathological language and/or social development, nor pathological variation in the normal mechanisms of lexical access in reading are necessary causes for reading precocity in early childhood. A model for integrating subtypes of precocious readers with subtypes of normal and dyslexic readers is proposed.
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PMID:Unexpected reading precocity in a normal preschooler: implications for hyperlexia. 381 52

A first-person account of the experience of autism is presented by a 22-year-old man who was first evaluated at the Yale Child Study Center at 26 months of age. His history and current status are reviewed. Factors related to outcome and diagnostic issues are discussed. Such accounts may be helpful in guiding research.
J Autism Dev Disord 1985 Mar
PMID:The experience of infantile autism: a first-person account by Tony W. 398 Apr 29


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