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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Rett syndrome is characterized by a progressive development of loss of intellectual functions and of motricity, including abnormal stereotypic hand movements and reduction of the motor skill. This syndrome is exclusively observed in girls. Its typical evolution is characterized by a normal initial development (until 6 to 18 months after birth) followed by a progressive installation of the clinical signs in 4 steps. There is currently no biological marker for the Rett syndrome and therefore the diagnosis is only based on clinical criteria. The most common erroneous diagnosis is infantile autism. In this review, the current status of clinical, genetic and pathogenetic knowledge of the Rett syndrome is presented.
Rev Prat 1991 Sep 15
PMID:[Rett syndrome. A well defined but mysterious encephalopathy]. 192 80

Magnetic resonance imaging (MRI) was performed in 270 patients with various neurologic complaints (1-15 Y) with a 0.5 tesla superconducting imaging system (MRT-50 A, Toshiba Co.) using a field echo sequence (TR/TE: 300 ms/14 ms) and a spine echo sequence (TR/TE: 2,000 ms/100 ms or 2,000 ms/120 ms, and 2,000 ms/30 ms). The slice thickness was 10 mm. Hyperintensity areas on T2-weighted images were noted at the occipital lobe in 33 patients (12.2%). Twenty-seven of them had hyperintensity within the deep white matter, which revealed iso- or hypointensity on T1-weighted images. The diagnosis for the 27 patients included medulloblastoma after multidisciplinary therapy (1), congenital heart disease (1), neurofibromatosis (1), tuberous sclerosis (1), congenital muscular dystrophy (1), congenital myotonic dystrophy (2), febrile convulsion (2), autism (3), epilepsy (9) and unknown causes (6). Because the hyperintensity areas are age-dependent, they may result from delayed myelination in the central nervous system.
No To Hattatsu 1991 Sep
PMID:[Deep white matter hyperintensity in occipital lobe on T2 weighted magnetic resonance imaging]. 193 Nov 65

Three patients with hyponatremia were found at an residential home of mental developmental delay. Because pimozide had been administered to all of them, it was suggested that pimozide might have induced compulsive water drinking resulting in hyponatremia. To my knowledge, there has been no previous report that pimozide may induce hyponatremia. As children with mental developmental delay and/or autism frequently develop epilepsy, hyponatremia should be included in the differential diagnosis of convulsive seizures. Particularly when antipsychotic drugs such as pimozide have been given, we should pay attention to polydipsia, polyuria and/or general malaise and prevent hyponatremia.
No To Hattatsu 1991 Sep
PMID:[Three cases of hyponatremia during administration of pimozide]. 193 Nov 69

In an effort to address the controversy regarding the use of aversive interventions in the treatment of individuals with developmental disabilities, this paper presents a review of the literature on the efficacy of such interventions, along with brief reviews of the ethical and legal issues involved. In general, there appears to be empirical, ethical, and legal support for the continued availability of aversive interventions as treatment options, but only if sufficient safeguards are in place.
J Autism Dev Disord 1991 Sep
PMID:Social policy on the use of aversive interventions: empirical, ethical, and legal considerations. 193 73

Preschool children with autism and their normally developing peers were compared on the Stanford-Binet IV and Preschool Language Scale before and after 1 school year. Both measures showed that although the children with autism functioned at a lower level than their normally developing peers, the children with autism had narrowed this gap after treatment, making a nearly 19-point increase in IQ and an 8-point gain in language quotient. The IQ measure remained stable for the normally developing peers while their language showed a 7.73-point increase. The data support the notion that young children with autism can make very significant developmental gains.
J Autism Dev Disord 1991 Sep
PMID:Changes in cognitive and language functioning of preschool children with autism. 193 74

Examined thought disorder in a sample (n = 11) of high-functioning autistic young adults and older adolescents (mean IQ = 83) utilizing objective ratings from the Thought, Language and Communication Disorder Scale (TLC Scale) and projective data from the Rorschach ink blots. Results from the TLC Scale pointed to negative features of thought disorder in this sample (e.g., Poverty of Speech). Rorschach protocols revealed poor reality testing and perceptual distortions in every autistic subject, and also identified several areas of cognitive slippage (e.g., Incongruous Combinations, Fabulized Combinations, Deviant Responses, Inappropriate Logic). Comparing TLC Scale and Rorschach results to schizophrenic reference groups, autistic subjects demonstrated significantly more Poverty of Speech and less Illogically on the TLC Scale, and on the Rorschach they evidenced features of thought disorder that are encountered also in schizophrenia. Results are discussed in relation to the measures employed, and to areas of similarity and difference between autism and schizophrenia.
J Autism Dev Disord 1991 Sep
PMID:Though disorder in high-functioning autistic adults. 193 75

Two firsthand accounts from verbal, high-functioning individuals with autism are presented. Participants include a 27-year-old man and a 13-year-old boy and his parents. Data collection included participant observation, formal and informal interviewing, correspondence, and collection of personal documents such as poems, art work, and essays. It was our aim to explore the participants' perceptions, mental processes, and experiences of living with autism. Five salient themes are identified and discussed: sensory processing, memory, stereotypical behaviors, social interaction, and empathy. Multichanneled sensory processing appeared in both participants, as well as a remarkably detailed memory of past events. Both participants were able to bring their stereotypical behaviors under voluntary control as a result of their awareness of nonautistic individuals' reactions to these behaviors.
J Autism Dev Disord 1991 Sep
PMID:Exploring the experience of autism through firsthand accounts. 193 76

A Chinese calendar savant was investigated on his exceptional proficiency in calendar calculation and his culture-specific talent of converting the Gregorian calendar to the Chinese calendar. Results did not support any one of the hypotheses of eidetic imagery, high-speed calculation, rote memorization, keying-off (anchoring) strategy, use of calendar regularities or monthly configuration as the only explanation proposed in earlier investigations. The savant's calculation ability is hypothesized to be brought about by his familiarity of the 14 calendar templates and the knowledge of matching the templates to every year. For dates that are beyond the 20th century, the calculation is by regressing the date to a corresponding year in the 20th century by additions or subtractions of 28 or 700 years with his accurate use of the simple operations in arithmetic.
J Autism Dev Disord 1991 Sep
PMID:An investigation of the calendar calculation ability of a Chinese calendar savant. 193 77

Brainstem auditory evoked potentials were compared in 109 children with infantile autism, 38 with autistic condition, 19 with mental retardation, and 20 normal children. Children with infantile autism or autistic condition had significantly longer brainstem transmission time than normal (p less than .001). Autistic features, rather than age, sex, or lower mentality, correlated with brainstem transmission time (p less than .0001). The autistic characteristics may be related to dysfunction of the brainstem which affects the processing of the sensory input through the auditory pathway. The brainstem lesion may be part of a generalized process of neurological damage that accounts for the deviant language, cognitive, and social development in the spectrum of autistic disorder.
J Autism Dev Disord 1991 Sep
PMID:Brainstem auditory evoked potential study in children with autistic disorder. 193 78


J Autism Dev Disord 1991 Sep
PMID:Brief report: biological factors associated with Asperger syndrome. 193 79


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