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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A combined informant questionnaire and interview survey of self-injurious behavior (SIB) at a large state facility for the retarded was conducted independently three times over a 3-year period. Prevalence consistently was about 10% of the population. SIB cases tended to be younger and institutionalized longer than the rest of the population. Severe cases had a longer history of chronic SIB. SIB cases had more seizure disorders, severe language handicaps, visual impairments, and severe or profound retardation than the rest of the population. They appeared to fulfill most of the Rutter (1966) criteria for autism. But unlike the severely autistic, there was little relation of sex to incidence of SIB. Over 90% of SIB cases changed status over 3 years, suggesting that SIB was amenable to behavior modification in most cases (94%). Psychotropic behavior control medications helped in some intervention programs (32%). SIB remitted spontaneously in 21% of SIB cases where there had been no behavioral or drug intervention.
J Autism Child Schizophr 1978 Sep
PMID:Prevalence of self-injurious behaviors in a large state facility for the retarded: a three-year follow-up study. 2 30

A sample of 74 young autistic children was selected and defined by direct observation of specific behaviors and clinical assessment of the presence or absence of associated pathological conditions. Retrospective developmental data on these children and 38 age-matched normal children were gathered by means of a written inventory completed by the parents when the children were relatively young (mean age less than 4 years). The autistic children were reported to have had significant delays in the development of motor abilities, speech, communication, comprehension, and, to a lesser extent, perception during their 1st and 2nd years.
J Autism Child Schizophr 1977 Sep
PMID:The early development of autistic children. 7 Dec 92

A comparative study of developmentally disturbed children as well as normal children is presented with a focus on their position in the family. Demographic data were compared for three groups of Japanese children, with a mean age of 4 years 7 months, who were diagnosed as autistic, cerebral palsied, and trisomic (trisomy 21 mongoloid). The areas compared were maternal age at birth, ratio of males to females, number of siblings, birth order, and age interval between the subject and the closest younger sibling. The normal kindergarten children with a mean age of 4 years 6 months, as well as the Japanese general population, were also compared for these demographic items. The findings on maternal age and sex ratio for these three nosological groups are consistent with recent studies. Although the reproduction of mothers of either cerebral palsied or mongoloid children ceases after the birth of the propositi, the reproduction of mothers of autistic children does not show significant difference from that of normal children's mothers. The age intervals between the subjects and the closest younger sibling do not differ among the three groups or in the normal group.
J Autism Child Schizophr 1975 Sep
PMID:Intrafamilial incidence of autism, cerebral palsy, and mongolism. 12 44

Thirty normal children (aged 3--68 months) and 16 autistic children (aged 36--62 months) were recorded during nonmedicated sleep and data pertaining to rapid eye movements (REM) were measured during the first three REM periods of the night. When time of night from which data were gathered was held constant, normal children showed a significant relationship between age and the organization of eye movements into discrete bursts. When autistic children were compared to age-matched normal controls, they showed an immaturity in this phenomena, their results being similar to those found in children less than 18 months of age. Such an immaturity could result from dysfunction at a number of diverse levels and sites in the central nervous system.
J Autism Child Schizophr 1976 Sep
PMID:Rapid eye movement (REM) activity in normal and autistic children during REM sleep. 18 48

A previous report suggested that plasma dopamine-beta-hydroxylase (DBH) is elevated in childhood autism. We measured plasma DBH in 15 Children with functional psychosis and in 10 psychotic children with known organic etiology. DBH activity was significantly elevated in the children with functional psychoses and showed a significant correlation with age that is not reported for this age range in normals. It is possible that children with functional psychoses show an abnormal continuation of the rise in plasma DBH activity characteristic of infancy. No differences between children with functional psychoses and children with organic psychoses were found for red blood cell catechol-O-methyl-transferase, plasma monoamine oxidase, or plasma cyclic AMP.
J Autism Child Schizophr 1978 Sep
PMID:Plasma dopamine-beta-hydroxylase in childhood psychosis. 21 Nov 13

The historical background and early contributions of the Emma Pendleton Bradley Hospital, the first psychiatric hospital for children in the United States, are described. The focus of this report is on the incorporation of the treatment modality of behavior modification into this traditional psychoanalytically oriented program. Beginning with exploratory studies in the mid-1960s, in recent years within the residential center there has been a separate Autistic Unit, in which the major treatment strategy is consistent application of behavior modification principles and programs. Changes that have occurred in the course of developing the behavior modification program are discussed to show some of the positive and negative aspects of introducing such a radical change into a traditional setting. Case studies are included to reveal both the failures and the successes that have been encountered in treating psychotic children with either psychotherapy or behavior therapy. Description of the current status of the program shows that treatment is comprehensive, including psychodynamic and behavioral approaches, medication when warranted, and special education. The role of parents in the program is now very different from that ascribed to them in traditional psychoanalytically guided treatment.
J Autism Child Schizophr 1977 Sep
PMID:Integration of a behavior modification program into a traditionally oriented residential treatment center for children. 33 85

Dermatoglyphic comparisons were made among 32 autistic children aged from 4-10 to 18-11; sex-, age-, and IQ-matched retarded children; and sex- and age-matched normal children. Significant differences were found between the autistic and normal children for distribution of dermal patterns and ridge line disruption, but no significant differences were found for the total mean ridge counts or mean ridge count rankings. Apart from the right hand of the autistic children, there were no unusual scores for digital dispersion ratios. Autistic and retarded children differed only in their distribution of dermal patterns, with the autistic children apparently intermediate between retarded and normal groups. These results indicate that conclusions of unique congenital disturbance in the etiology of autism inferred from different dermatoglyphics may be premature, and that dermatoglyphics may be ineffective in delineating autistic children from other atypical populations.
J Autism Dev Disord 1979 Sep
PMID:A comparative dermatoglyphic study of autistic, retarded, and normal children. 48 10

The long-recognized difficulties of the speaking autistic child with the use and nonuse of personal pronouns ["reversals" and "avoidance"] have been generally attributed either to the nondifferentiation of the self or to the frequently coexisting symptom of echolalia. These explanations are reconsidered in this eclectic analysis from the perspective of current theory and research in development of self and of language. Emphasis is on studies of normal development of personal pronouns and the roles played in that process by listening, echoic memory, mitigated echolalia [recoding], and person deixis. It is concluded that multiple developmental obstacles of a social, cognitive, and grammatical nature underlie the more obvious symptoms and militate against the child's resolution of labels and their referents. Treatment alternatives that de-emphasize the primacy of I are offered.
J Autism Dev Disord 1979 Sep
PMID:Personal pronouns and the autistic child. 48 11

It is argued that the general learning difficulties exhibited by mentally retarded persons are similar in many respects to the learning difficulties of nonretarded persons who are in a state of learned helplessness (Seligman, 1975) or who are external in locus of control orientation. It is suggested that studies of locus of control and learned helplessness as theoretical constructs both directly concern the perceiving of relationships between behavior and outcomes, and that a systematic investigation of perception of contingency might increase our understanding of some of the learning difficulties of mentally retarded persons. An overview is given of the results of the few studies that have addressed perception of contingency and mental retardation, and suggestions for future research are offered.
J Autism Dev Disord 1979 Sep
PMID:Perception of contingency and mental retardation. 48 12

Six cases of childhood psychosis in children 3 to 5 years of age are summarized in order to alert clinicians to include this clinical entity in the differential diagnosis of children with major developmental difficulties. They represent children treated in a day, nonresidential treatment facility in a suburb of New York City. These cases suggest that we reexamine the prevalent interest in a bipolar distribution of childhood psychosis that focuses on children whose psychosis occurs under 3 and over 5 years of age. Children with psychosis occurring between 3 and 5 are currently described as essentially rare, and are characterized by a path of massive deterioration. Our cases indicate that we should be alert to the phenomenon of young children with psychosis appearing at the preschool age, and in whom the course of illness is in a more positive direction.
J Autism Dev Disord 1979 Sep
PMID:Childhood psychosis in the preschool child. 48 13


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