Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The following case report based on a 25-year experience with a high-functioning autistic child is offered (1) to provide some historical perspective on our approaches to ASD over the past 25 years, and (2) to illuminate some areas of continuing need for improvement.
J Autism Dev Disord 2008 Jan
PMID:Brief report: 25-year follow-up of a high-functioning autistic child. 1736 31

This paper identifies family characteristics associated with use of autism-related services. A telephone or in-person survey was completed during 2003-2005 by 383 North Carolina families with a child 11 years old or younger with ASD. Access to care is limited for racial and ethnic minority families, with low parental education, living in nonmetropolitan areas, and not following a major treatment approach. Service use is more likely when parents have higher stress. Families use a broad array of services; the mix varies with child ASD diagnosis and age group. Disparities in service use associated with race, residence and education point to the need to develop policy, practice and family-level interventions that can address barriers to services for children with ASD.
J Autism Dev Disord 2007 Nov
PMID:Access to care for autism-related services. 1737 17

While knowledge about symptom presentation of adults with mild ASD, including comorbid psychopathology, is limited, referral of adults with suspected mild PDD is increasing. We report on pilot research investigating whether patients diagnosed with mild ASD (n=15) and patients who were not diagnosed with ASD (n=21) differed in terms of (a) AQ scores and (b) Axis I and II disorders, assessed by the SCAN and the IPDE. Additionally, AQ scores were compared with those from non-ASD patients referred to a general outpatient clinic (n=369). The results showed very few differences between ASD patients and non-ASD patients. Self-report may not differentiate mild ASD patients from non-ASD patients and Axis I and II disorders seem equally prevalent among these two groups.
J Autism Dev Disord 2008 Jan
PMID:Brief report: adults with mild autism spectrum disorders (ASD): scores on the autism spectrum quotient (AQ) and comorbid psychopathology. 1738 86

The Fifth Edition of the Stanford-Binet Intelligence Scales (SB5; Roid, G. H. (2003). Stanford Binet intelligence scales (5th ed.). Itasca, IL: Riverside Publishing) is relatively new, with minimal published research on general populations and none with special populations. The present study provides information on the cognitive profiles of children with ASD (N=63) and on the whether the abbreviated battery is representative of the full scale. A high percentage of the children had significantly stronger nonverbal (vs. verbal) skills. This pattern was not related to Full Scale IQ, age or diagnostic subgroup. IQs derived from the abbreviated battery accounted for a large proportion of the variance in FSIQ relative to comparable abbreviated batteries. However, caution is warranted when using the abbreviated battery, as it misrepresents actual ability in a small percentage of cases.
J Autism Dev Disord 2008 Jan
PMID:Brief report: data on the Stanford-Binet Intelligence Scales (5th ed.) in children with autism spectrum disorder. 1741 Apr 16

This study investigated the factor structure of the Childhood Autism Rating Scale (CARS). Principal components analysis (PCA) and principal axis factor analysis (PAF) evaluated archival data from children presenting to a university clinic with suspected autism spectrum disorders (ASDs; N = 164). PCA did not replicate components identified by DiLalla and Rogers (1994, Domains of the Childhood Autism Rating Scale: Relevance for diagnosis and treatment. Journal of Autism and Developmental Disorders, 24(2), 115-128) and Stella, Mundy, and Tuchman (1999, Social and nonsocial factors in the Childhood Autism Rating Scale. Journal of Autism and Developmental Disorders, 29(4), 307-317). PAF identified correlated Social-Communication, Social Interaction, Stereotypies and Sensory Abnormalities, and Emotional Regulation factors. Results differed across studies; however, each identified ASD related constructs conceptually consistent with DSM-IV. Although its development predates the DSM-IV, and many newer measures are available, the CARS' psychometric properties, conceptual relevance, and flexible administration procedures support its continued use as a screening device in the diagnostic decision-making process.
J Autism Dev Disord 2007 Oct
PMID:Factor structure evaluation of the childhood autism rating scale. 1743 70

The Autism-Spectrum Quotient (AQ) children's version has confirmed reliability and validity in the UK. In the current study, the children's AQ was administered in Japan to investigate whether the UK results are found in a very different culture. Two groups of children from primary and secondary schools were assessed: Group 1 (n = 81) children with Autism Spectrum Disorders (ASD, including Asperger Syndrome and high-functioning autism); Group 2 (n = 372) randomly selected controls, age-matched with Group 1. The children with ASD had a mean AQ score of 31.9 (SD = 6.69), which was significantly higher than controls (mean AQ = 11.7, SD = 5.94). Males scored significantly higher than females in the control group, but not in the ASD group. The pattern of difference between the Japanese clinical group and the control group was remarkably similar to the findings in the UK.
 ...
PMID:[Autism-spectrum quotient (AQ) Japanese children's version " comparison between high-functioning children with autism spectrum disorders and normal controls]. 1744 62

Autism diagnostic practices among school and clinical psychologists, particularly those using the Autism Diagnostic Observation Schedule (ADOS), were examined using national survey results (N = 132). School and clinical psychologists were similar in following the Best Practice Guidelines for screening, diagnosis and assessment, School psychologists were more likely to include a school or home observation and teacher report than clinical psychologists but evaluated significantly fewer children with autism spectrum disorders per year compared to clinical psychologists. School psychologists who were ADOS users were more likely to consider themselves autism experts and include a review of records than ADOS non-users. Perceived advantages of the ADOS included its strength in capturing ASD-specific behaviors and the standardized structure provided for observation, while diagnostic discrimination and required resources were the most commonly identified disadvantages.
 ...
PMID:The Role of the Autism Diagnostic Observation Schedule in the Assessment of Autism Spectrum Disorders in School and Community Settings. 1750 22

We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.
Autism 2007 Jul
PMID:Developmental regression and autism reported to the Vaccine Adverse Event Reporting System. 1765 95

Nineteen people with Asperger syndrome (AS)/High-Functioning Autism (HFA) (ages 7-15) were tested on imitation of two types of meaningless gesture: hand postures and finger positions. The individuals with AS/HFA achieved lower scores in the imitation of both hand and finger positions relative to a matched neurotypical group. The between-group difference was primarily accounted for by performance on a test of visual motor integration, together with a hand imitation deficit which was specifically due to errors in body part orientation. Our findings implicate both visuomotor processes (Damasio and Maurer, 1978) and self-other mapping (Rogers and Pennington, 1991) in ASD imitation deficits. Following Goldenberg (1999), we propose that difficulties with body part orientation may underlie problems in meaningless gesture imitation.
J Autism Dev Disord 2008 Mar
PMID:Brief report: imitation of meaningless gestures in individuals with Asperger syndrome and High-Functioning Autism. 1766 96

It has been hypothesised that autism is an extreme version of the male brain, caused by high levels of prenatal testosterone (Baron-Cohen 1999). To test this proposal, associations were assessed between three visuo-spatial tasks and prenatal testosterone, indexed in second-to-fourth digit length ratios (2D:4D). The study included children with Autism Spectrum Disorder, ASD (N = 28), and chronological as well as mental age matched typically-developing children (N = 31). While the group with ASD outperformed the control group at Mental Rotation and Figure-Disembedding, these group differences were not related to differences in prenatal testosterone level. Previous findings of an association between Targeting and 2D:4D were replicated in typically-developing children and children with ASD. The implications of these results for the extreme male brain (EMB) theory of autism are discussed.
J Autism Dev Disord 2008 Mar
PMID:Visuo-spatial processing in autism--testing the predictions of extreme male brain theory. 1832 35


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>