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Target Concepts:
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Query: UMLS:C0004352 (
autism
)
32,579
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To evaluate the application values of<sup>99m</sup>Tc-2 β [N, N′ , - bis (2-mercaptoethy1) ethylenediamino] methyl, 3 β -(
4-chlorophenyl
) tropane (TRODAT-1) dopamine transporter (DAT) SPECT imaging in children
autism
, and offer the academic foundation to etiology, mechanism and clinical therapy of
autism
. Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum [(STR-BKG)/BKG]. There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (p=0.562) and in normal controls (p=0.573); Dopamine transporter in brain of patients with
autism
increased significantly than that in normal controls (p=0.017). Dopaminergic nervous system is dysfunction in human brain with children
autism
, and DAT 99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children
autism
.
...
PMID:Study of 99mTc-TRODAT-1 imaging on human brain with children autism by single photon emission computed tomography. 1728 54
This study was conducted to evaluate the applicability of 99mTc-2beta-[ N, N'-bis (2-mercaptoethyl) ethylenediamino]methyl,3beta(
4-chlorophenyl
)tropane(TRODAT-1) dopamine transporter(DAT) SPECT imaging in children with
autism
, and thus to provide an academic basis for the etiology, mechanism and clinical therapy of
autism
. Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratics between striatum and cerebellum [(STR-BKG)/BKG]. There was no statistically significant difference in semiquantitative dopamine transporter between the bilateral striata of autistic children (P=0.562), and between those of normal controls (p=0.573); Dopamine transporter in the brain of patients with
autism
increased significantly as compared with that in the brain of normal controls (P=0.017). Dopaminergic nervous system is dysfunctioning in the brain of children with
autism
, and DAT 99mTc-TRODAT-1 SPECT imaging on the brain will help the imaging diagnosis of childhcod
autism
.
...
PMID:[Study of dopamine transporter imaging on the brain of children with autism]. 1861 Jun 16
