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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This short novel is the story of the perplexity of a statistician travelling for more than a decade in the quicksands of quantitative psychopathology, from the nonvalidated concepts of the DSM-III to their validation by the Dexamethasone Suppression Test whose validity is ignored, from the "mathematical" concepts of Lacan to items suppressed from the AMDP-System, such as autism, because of a lack of agreement of the psychiatrists on objective criteria. The author concludes with a note of hope: comprehensive scales like the AMDP, combined with biological predictors, should facilitate the discovery of new psychotropic drugs, more specific for certain syndromes, hence contributing to new classificatory models.
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PMID:[What do you say, agnostic?]. 360 25

This paper reports on the correlates of psychiatric illness in children with speech and language disorders. Of 600 children selected from a community speech clinic, 50% were found to have diagnosable psychiatric disorders according to DSM-III criteria. These "psychiatrically ill" children were compared to the "psychiatrically well" children in the sample on a variety of developmental, socioeconomic, medical, and psychosocial factors. Although some differences were found between the well and ill children in other factors, the majority of the differences, and the most highly significant differences, were found in areas of linguistic functioning. It is hypothesized that this finding may be relevant not only to understanding the association between linguistic and psychiatric functioning but also to predicting the outcome and planning treatment for childhood speech and language disorders.
J Autism Dev Disord 1987 Dec
PMID:Factors associated with the development of psychiatric illness in children with early speech/language problems. 368 Jan 52

Asperger's syndrome is an autistic-like disorder, probably neuropsychiatric in character, which fits with DSM-III criteria for Atypical Pervasive Development Disorder. Because the abnormality is less pervasive than Autistic Disorder, it may be misdiagnosed as Personality Disorder in the adolescent, and the author presents an illustrative case in this respect. The condition is sometimes associated with Tourette's Syndrome, though not in this particular patient. Treatment remains speculative.
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PMID:A possible case of Asperger's syndrome. 369 Apr 75

Subtypes of thought disorder and affective flattening were examined in 14 adults with clear DSM-III diagnoses of infantile autism or autism, residual state, using videotaped psychiatric interviews and objective rating scales. Schizophrenic, manic, and normal subjects constituted contrast groups. Autistic adults, most of whom were high functioning, showed a high incidence and severity of poverty of speech, poverty of content of speech, perseveration, and affective flattening. They showed significantly less derailment, illogicality, and other features of "positive thought disorder" than either the schizophrenic or manic group, but they did not differ from schizophrenics on any affective flattening variable.
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PMID:Thought, language, communication, and affective flattening in autistic adults. 372 72

Classical infantile autism occurs more frequently in males and has recently been noted in patients with the fragile (X) form of X-linked mental retardation (XLMR). In order to better understand this association and to determine whether fra(X) XLMR could account for the excess of autistic males, we investigated a group of institutionalized severely handicapped adults, 33 males and eight females, who were diagnosed as autistic using the DSM III diagnostic criteria of infantile autism. Chromosome studies using FUdR showed that three of the males had the Xq27 fragile site. We confirmed the association of autism and fra(X) XLMR, and showed that this extreme form of behaviour is part of the spectrum seen in the Martin-Bell syndrome. Two of the three autistic males with the Xq27 fragile site had a history of birth insults, which in combination with developmental deficits due to the fragile X gene, might have led to the behavioural disorder. Even though the fragile X cannot account for the excess of males with classical autism, it is an important X-linked factor in its cause. The diagnosis can allow more accurate counselling for this subset of autistic males.
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PMID:Infantile autism: an occasional manifestation of fragile (X) mental retardation. 395 53

Fifty males with the fragile X [fra(X)] syndrome, which we consider synonymous with the Martin-Bell syndrome, were identified by a chromosome analysis of patients with developmental delays or mental retardation and family studies of known fra(X) pedigrees. These males were evaluated for autism using three criteria: 1) the DSM III diagnostic criteria for Infantile Autism; 2) the Autism Behavior Checklist (ABC); and 3) the Diagnostic Checklist for Behavior Disturbed Children, Form E2. Sixteen percent of patients fulfilled all of the DSM III criteria for Infantile Autism and an additional 30% fulfilled criteria for Infantile Autism Residual State. Thirty-one percent of patients had autism using the ABC checklist but none of the patients fit the classical Kanner syndrome as described by the E2 questionnaire. Some autistic traits were seen in almost all of the 50 fra(X) patients, including eye avoidance in 90%, handflapping, handbiting or handstereotypies in 88%, and language delays with language peculiarities, usually echolalic speech, in 96%. A pervasive lack of responsiveness was seen in 18% at their present age and in 44% in earlier childhood only. Autistic symptoms are common in the fra(X) syndrome. Therefore, any patient with developmental delays and autism or autistic manifestations should have a chromosomal analysis, including fra(X) examination.
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PMID:An analysis of autism in fifty males with the fragile X syndrome. 395 54

In order to assess further the occurrence of hypothalamic dysfunction in infantile autism and its possible relationship to dopaminergic abnormalities, the l-dopa provocative test was performed in 22 patients fulfilling DSM-III criteria for this disorder. The results indicate a high incidence (at least 30%) of blunted plasma growth hormone (GH) responses following oral administration of l-dopa in this sample. These data suggest an alteration of hypothalamic dopamine receptor sensitivity in the patients with blunted responses. Thus, a subgroup of autistic patients within a descriptively homogeneous diagnostic category shows evidence of hypothalamic dysregulation and dopaminergic abnormalities.
J Autism Dev Disord 1985 Jun
PMID:Plasma growth hormone response to oral l-dopa in infantile autism. 399 47

In DSM-III, pervasive developmental disorder is divided into two major categories: infantile autism and childhood onset pervasive developmental disorder. The criteria differ, primarily, in the age of onset. The authors studied 129 patients who had received diagnoses of pervasive developmental disorder or a related disorder and found only five cases of apparent childhood onset pervasive developmental disorder. These five patients were behaviorally indistinguishable from those with other diagnoses. Practically, age of onset may be more appropriately termed "age of recognition," and its use as a major diagnostic criterion for such disorders may not be justified.
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PMID:Age of recognition of pervasive developmental disorder. 407 10

The autistic child's problems with language may be an impairment in symbolic functioning that affects all forms of communication, including representational thought and the ability to play creatively. The hypothesis that autistic children specifically do not project symbolic meaning onto toys (which is not associated with other conditions causing severe language disorder) was tested in a group of 15 severely language-impaired children. Data were obtained from a parent interview/questionnaire and analysis of a video-taped play session. The findings suggest that language-disordered children who meet DSM III criteria for autism most consistently show absence of symbolic play, and those who do have symbolic play fall into a wide range of diagnostic categories excluding autism. The report presents valuable observational and interpretational clinical factors, useful in the assessment and differential diagnosis of a language-impaired child.
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PMID:Play assessment in the differential diagnosis of autism and other causes of severe language disorder. 619 74

Twenty boys meeting the current DSM III criteria for infantile autism at the time of diagnosis were found to be hyperlexic in childhood and have been followed up for 7-17 years. The most striking feature of the group was the compulsion to decode written material without comprehension of its meaning, and this constituted a behavioral phenotype for this population. On word recognition tests such as the WRAT, they scored significantly higher than would be predicted on the basis of intelligence but demonstrated severe reading retardation on tests of reading comprehension such as the Gates-McGinitie. Major differences in intelligence were detected, ranging from severe mental retardation to very superior intelligence. Major differences in verbal and nonverbal abilities were also noted. Many were found to have unusually good memory, both visual and auditory, and the majority possessed an excellent stored vocabulary that could be used with written words despite the poverty of their expressive language. It is suggested that the presence of hyperlexia may identify a subgroup of autistic children.
J Autism Dev Disord 1984 Sep
PMID:Hyperlexia in infantile autism. 648 May 46


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