Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004352 (
autism
)
32,579
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The primary aim of the present study was to investigate alterations in enzymes associated with fatty acid synthesis, namely fatty acid synthase (FASN) and
acetyl-CoA carboxylase
(
ACC
), in the prefrontal cortex and cerebellum of the valproic acid (VPA)-induced animal model of
autism
. In this model, pregnant rats were given a single intraperitoneal injection of VPA, and prefrontal cortex and cerebellum samples from their pups were analyzed. The results of western blotting and reverse transcription-quantitative polymerase chain reaction analyses demonstrated that the protein and mRNA expression levels of FASN,
ACC
and phospho-
ACC
(pACC) were increased in the prefrontal cortex and cerebellum of the VPA model of
autism
. Furthermore, in the prefrontal cortex and cerebellum of the VPA model of
autism
, AMPK expression is increased, whereas PI3K and Akt expression are unchanged. This suggests that disorder of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt/FASN and/or adenosine 5'-monophosphate-activated protein kinase (AMPK)/
ACC
pathway may be involved in the pathogenesis of
autism
. It is hypothesized that fatty acid synthesis participates in
autism
through PI3K/Akt/FASN and AMPK/
ACC
pathways.
...
PMID:Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. 2760 61
