Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004352 (
autism
)
32,579
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of
Vitamin K
on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of
Vitamin K
overlap with key brain development aberrations, including those associated with
autism
. Furthermore,
Vitamin K
protects against oxidative stress associated with toxic exposure. Research on the neural effects is reviewed, and a small sample of severely autistic children of Somali descent residing in the Minneapolis/St. Paul area of Minnesota were genotyped and found to have a higher than expected genetic substitution that results in reduction in the efficiency of the
Vitamin K
cycle. The possibility that this genetic difference could play an etiological role in the development of
autism
is considered.
...
PMID:Speculations on vitamin K, VKORC1 genotype and autism. 2795 70
