Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aggression and self injurious behaviors are associated with some clients with autism and other forms of pervasive developmental disorder. These behaviors are not well understood, and treatment interventions are often ineffective. This article describes these behaviors in terms of the underlying deficits of autism, suggesting that interventions may be more effective if targeted at the underlying causes of the actions. The article presents behaviors and underlying causes within an "iceberg" conceptualization with visible behaviors depicted as occurring "above the water line" and hypothesized causes hidden "below the water line" of the iceberg. Examples of clinical cases are presented to illustrate the usefulness of the conceptualization.
 ...
PMID:Aggression and self-injurious behaviors in persons with autism--the TEACCH (Treatment and Education of Autistic and related Communications Handicapped Children) approach. 813 16

The authors obtained neurological assessments and psychiatric family history data for 40 children with autistic spectrum disorders (autism, Asperger syndrome and pervasive developmental disorder). Neurological evaluation included EEG, MRI, karyotyping and positron emission tomography as indicated. Family history data were obtained from family members during long-term follow-up. 20 probands had positive neurological findings, 18 with negative family history. 14 had no neurological findings and positive family histories; they tended to have higher function. Six had neither, and two had both. The segregation of neurological findings and familial affective disorder was highly significant. These findings suggest that an important subgroup of autistic spectrum disorders may be related etiologically to familial major affective disorders, and may represent the early-life onset of a severe phenotype of major affective, particularly bipolar, disease.
 ...
PMID:Psychiatric family history and neurological disease in autistic spectrum disorders. 816 63

In the world literature findings of morphological abnormalities in the area of the brain and cerebellum in children with pervasive developmental disorders are encountered. The authors of the present article describe in three case-records morphological abnormalities of the brain and cerebellum found in subjects with markedly expressed or only indicated signs of child autism. At the same time they draw attention to the possible determination of experience and behaviour of subjects with discrete morphological abnormalities, even when the pervasive developmental disorder was not diagnosed but where specific determination of premorbid experience and behaviour, as well as the clinical picture of a possible mental disorder or disease.
 ...
PMID:[Does juvenile autism have a morphologic basis?]. 817 82

The purpose of this study was to assess the relationship between autism and childhood psychosis. Fifteen children with psychotic symptoms were compared to 15 children with autism, using two observational measures, the Ritvo-Freeman Real Life Rating Scale (RLRS) and the Childhood Autism Rating Scale (CARS), which rate subjects on behaviors pathognomic to autism. In comparison to autistic persons, psychotic individuals were judged to have better language and social skills. In addition, autistic persons were also rated as having more difficulty adapting to new situations and appeared more "autistic-like." Overall scores on the CARS and RLRS were significantly different between the two groups, indicating that these two assessment instruments may be useful in differential diagnosis. However, 20% of the psychotic subjects received pervasive developmental disorder diagnoses, indicating that there may be a relationship between those two disorders.
J Autism Dev Disord 1994 Feb
PMID:Comparison of psychotic and autistic children using behavioral observation. 818 76

A questionnaire (the Wing Subgroups Questionnaire, or WSQ) for subclassifying children with autism into one of Wing's three hypothesized subgroups was developed, and the validity of this measure was assessed. Forty parents of children with autism or pervasive developmental disorder not otherwise specified (PDDNOS) completed the questionnaire. Results indicated that the questionnaire has adequate external criterion-referenced validity with similar subgroup ratings made by clinicians, and good internal consistency. Furthermore, results revealed three distinct and separate subgroups corresponding to Wing's subclassification scheme. Other analyses suggested that Wing assignment based on the WSQ was independent of chronological age and age equivalents for social and daily living skills, but not independent of diagnosis of autism vs. PDDNOS, IQ, severity of autism, sex, receptive language mental age, and age equivalents for communication skills. Finally, a discriminant analysis indicated that, of all the dependent variables examined in the present study, the clinicians' Wing assignment was the best predictor of Wing assignment based on the parent-completed WSQ. These findings provide support for Wing's classification system, and suggest that the WSQ is a valid and useful tool for subclassifying individuals with autism.
J Autism Dev Disord 1993 Jun
PMID:Subclassification of children with autism and pervasive developmental disorder: a questionnaire based on Wing's subgrouping scheme. 833 Oct 45

An estimate of the prevalence of autism in tuberous sclerosis (TSC) was made by interviewing the parents of 21 children between ages 3 and 11 ascertained during a previous population study of the condition in the West of Scotland. Five of the children (24%) were rated autistic and a further four (19%), all of whom were girls, had socially impaired behavior categorized as pervasive developmental disorder, without fulfilling all the DSM-III-R criteria for autism. One further boy had disruptive attention-seeking behavior that had excluded him from his normal school. The estimated prevalence from this study of autism in TSC is 1 in 4 children in general, and 1 in 2 of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders, particularly in girls.
J Autism Dev Disord 1993 Jun
PMID:A prevalence study of autism in tuberous sclerosis. 833 Oct 50

An investigation of children with pervasive developmental disorder (PDD) was conducted using a new instrument, the Kiddie-Infant Descriptive Instrument for Emotional States (KIDIES). The KIDIES rates several affective and behavioral dimensions based on facial, vocal, gestural, and postural cues. The study's goals were to determine whether the KIDIES could detect individual differences in responsivity among the PDD subjects; to ascertain the KIDIES' sensitivity in identifying group differences between PDD subjects and control children with other developmental disorders. Children were videotaped during episodes with three partners: the mother, a familiar female teacher, an unfamiliar male doctor. Episodes were scored using the KIDIES. PDD subjects were most severely impaired during the Mother episode in comparison to the controls. Equally as striking was the within-episode heterogeneity among PDD subjects. During the Teacher episode, PDD subjects were twice as variable in interpersonal response as the controls.
J Autism Dev Disord 1993 Jun
PMID:Assessing the relationship between affective responsivity and social interaction in children with pervasive developmental disorder. 833 Oct 52

Autism is a pervasive developmental disorder with onset in infancy or childhood. Research has identified infant/toddler characteristics that should suggest autism to pediatric primary care providers. Many autistic children can be referred for diagnosis as young toddlers if social, perceptual, and language delays are considered significant. Early diagnosis of children with autism allows intervention, which helps the child modulate disturbing sensory stimuli and seeks to meet his/her unique social and communication needs. This article describes the disorder and its management and offers guidelines for recognizing young children who would benefit from further comprehensive neurobiologic evaluations by developmental specialists.
 ...
PMID:Autism in young children: an update. 842 Dec 39

Autism and pervasive developmental disorder, not otherwise specified represent a complex developmental disability in which clinical signs include language delay, social unrelatedness, and unusual or restricted interests. Gradually a better understanding of these disorders as being neurologically-based developmental disorders with multiple etiologies has replaced the idea of emotional disturbance. Although pervasive developmental disorders are rare, the potentially devastating effects make early recognition by pediatricians imperative. Yet, despite promising treatment advances in education, communication technology, behavior treatments, and pharmacology, the prognosis for these disorders remains guarded.
 ...
PMID:Autism and pervasive developmental disorders. 849 66

The neurological, neurochemical, and neurotransmitter level differences as well as genetic influences associated with autism have been studied extensively in the last two decades. The varied findings from research offer hope for better understanding, effective treatment, and, perhaps, cure of this pervasive developmental disorder.
 ...
PMID:Psychophysiological aspects of autistic disorders: overview. 863 5


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>