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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnostic criteria for autism have been refined and made more objective since Kanner first described the syndrome, so there is now reasonable consistency in how this diagnosis is applied. However, many children do not meet these criteria, yet show some of the features of autism. Where language development is impaired, such children tend to be classed as cases of developmental dysphasia (or specific language impairment) whereas those who learn to talk at the normal age may be diagnosed as having Asperger's syndrome. It is argued that rather than thinking in terms of rigid diagnostic categories, we should recognise that the core syndrome of autism shades into other milder forms of disorder in which language or non-verbal behaviour may be disproportionately impaired.
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PMID:Autism, Asperger's syndrome and semantic-pragmatic disorder: where are the boundaries? 269 Sep 15

The term Asperger's Syndrome (AS) refers to a clinical picture characterized by social isolation in combination with odd and eccentric behaviour. While the syndrome has been recognized for some time, diagnostic criteria for the disorder have not yet been established or evaluated. The objective of this paper is to describe some of the clinical features of AS. Twenty-eight children and adolescents with AS were compared to a group of psychiatric outpatients (matched on age and sex) who were also socially impaired. The AS subjects showed a range of social impairments essentially different than those seen in the control group. The sex ratio, family history, and presence of neurologic disease in some AS cases, suggest that the etiology of the disorder is similar to that in autism. The methodological limitations of the study are discussed, and a revised set of diagnostic criteria are proposed for AS.
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PMID:Asperger's syndrome: a review of clinical features. 276 9

Attempts to explain infantile autism in terms of just one underlying neurological or psychological deficit may be misguided. As in the case of many neurological syndromes, autism may involve multiple functional deficits due to multiple coexistent neurological deficits. Comparison with Asperger's syndrome and the developmental dysphasias suggests that the autistic syndrome results from the coexistence of at least two distinct constellations of functional impairments: deficits in mechanical language skills, as in the developmental dysphasias; and deficits in social relatedness, play, and nonverbal communication, as in Asperger's syndrome. Possible neurological underpinnings are considered, including the relative contribution of the two cerebral hemispheres. Implications for etiology and research are discussed.
J Autism Dev Disord 1989 Sep
PMID:Infantile autism: a syndrome of multiple primary deficits? 279 86

Sixty-six psychotic children aged between two and 20 years, examined by the same child psychiatrist and diagnosed according to strict criteria as suffering from infantile autism, other psychoses and Asperger's syndrome, were examined with chromosomal cultures in folic-acid deficient medium. 47 per cent of the children showed major or minor chromosomal aberrations. The infantile autistic group comprised a total population of autistic children. The fra(X)(q27) marker was seen in 25 per cent of autistic boys. A subgroup of children with the fra(X)(q27) abnormality, infantile autism, psychomotor epilepsy and brainstem dysfunction was identified. Other chromosome markers and abnormalities occurring in several cases included long Y chromosomes, fra(X)(p22), fra(16)(q23) and fra(6)(q26). The results are discussed and correlated with certain clinical characteristics.
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PMID:Chromosome abnormalities in infantile autism and other childhood psychoses: a population study of 66 cases. 316 Jun 21

There is considerable disagreement on the classification of Asperger's syndrome and its relationship to autism. Unlike autism, Asperger's is not usually recognised before 30 months of age, and speech delay is not typical. However, if a child exhibits all the symptoms of autism apart from these two features, are these sufficient grounds for withholding a diagnosis of autism? This paper describes four boys and their father who, by presenting at various points on the autistic/Asperger spectrum, embody this dilemma for the diagnostician. The implications for research and clinical practice are discussed.
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PMID:Asperger's syndrome and autism: the case for a connection. 316 73

The etiology of infantile autism is not known. To assess the possible role of familial psychopathology, we investigated a group of autistic subjects subgrouped by level of language function. Family histories were obtained by the family history method. Neurological status was assessed by neurological diagnostic examination and prenatal and perinatal history. The results showed a high incidence of Asperger's syndrome in family members of high-functioning autistic subjects only. The rate of bipolar affective disorder in family members was 4.2%, higher than in the general population; it was significantly higher in families with Asperger's syndrome, suggesting an etiological link between Asperger's syndrome and manic depression. Positive neurological findings were concentrated in the low-functioning subgroup. These findings imply different etiologies for high- versus low-functioning autism, with high-functioning autism related to familial factors, especially Asperger's syndrome.
J Autism Dev Disord 1988 Dec
PMID:Correlation of family history with specific autistic subgroups: Asperger's syndrome and bipolar affective disease. 321 85

Asperger's Syndrome is assumed to be closely related to autism. A case of a 21-yr-old man with Asperger's Syndrome who is frequently violent to his 71-yr-old girlfriend is presented. According to a social-cognitive model of autism, this man is predicted to be markedly impoverished in his appreciation of his victim's thoughts and feelings. Interview-based assessments confirm this deficit, and this is discussed as an important factor in the maintenance of his violence.
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PMID:An assessment of violence in a young man with Asperger's syndrome. 341 10

An 18-year-old male, originally diagnosed as suffering from infantile autism but with a developmental history and clinical picture in keeping with Asperger's syndrome, and showing current signs of impairment of higher cerebral functioning, is presented. The subject and several males of his family present behavioural disturbances of an enduring type. An aminoaciduria was discovered in the subject and his father. A possible relationship between the metabolic disturbance and the neurological and behavioural disturbance is raised. Mechanisms for this relationship are discussed, including sporadic hyperlysinaemia.
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PMID:Asperger's syndrome and aminoaciduria: a case example. 366 13

Seventeen children with classical Kanner autism and three children with Asperger syndrome, all of whom had Full-scale IQs above 65, were subjected to a neurobiological assessment, including CAT scan, auditory brainstem response, EEG, chromosomal cultures, cerebrospinal fluid, blood and urine examinations and a thorough physical examination. 15 of the 20 children had 'definite abnormalities' on at least one of these examinations. It is concluded that the number of cases of 'non-organic' autism, even among children with relatively higher intelligence, dwindles rapidly as our neurobiological assessment methods become increasingly sophisticated.
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PMID:Neurobiological findings in 20 relatively gifted children with Kanner-type autism or Asperger syndrome. 366 27

Asperger's syndrome is an autistic-like disorder, probably neuropsychiatric in character, which fits with DSM-III criteria for Atypical Pervasive Development Disorder. Because the abnormality is less pervasive than Autistic Disorder, it may be misdiagnosed as Personality Disorder in the adolescent, and the author presents an illustrative case in this respect. The condition is sometimes associated with Tourette's Syndrome, though not in this particular patient. Treatment remains speculative.
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PMID:A possible case of Asperger's syndrome. 369 Apr 75


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