Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A combined informant questionnaire and interview survey of self-injurious behavior (SIB) at a large state facility for the retarded was conducted independently three times over a 3-year period. Prevalence consistently was about 10% of the population. SIB cases tended to be younger and institutionalized longer than the rest of the population. Severe cases had a longer history of chronic SIB. SIB cases had more seizure disorders, severe language handicaps, visual impairments, and severe or profound retardation than the rest of the population. They appeared to fulfill most of the Rutter (1966) criteria for autism. But unlike the severely autistic, there was little relation of sex to incidence of SIB. Over 90% of SIB cases changed status over 3 years, suggesting that SIB was amenable to behavior modification in most cases (94%). Psychotropic behavior control medications helped in some intervention programs (32%). SIB remitted spontaneously in 21% of SIB cases where there had been no behavioral or drug intervention.
J Autism Child Schizophr 1978 Sep
PMID:Prevalence of self-injurious behaviors in a large state facility for the retarded: a three-year follow-up study. 2 30

The current status of pharmacological treatments of self-injurious behavior (SIB) and aggression in persons with mental retardation and autism was reviewed in the literature. Much of the existing literature is derived from anecdotal clinical experience, with a relative lack of well-controlled studies to determine the efficacy of different treatments. Although all psychotropics have been used to manage SIB and aggression, particularly promising are the data on the use of opioid antagonists like naltrexone. Beta-blockers may also have some role, but more controlled, systematic studies are needed. Use of neuroleptics is on the decline because of their adverse effects, such as tardive dyskinesia and possible impairment of cognitive functions. We assert that the behavioral problems of SIB and aggression are at times manifestations of different psychiatric syndromes. They present in a modified, atypical form in the developmentally disabled population because of cognitive limitations. Further understanding and classification of the psychopathology associated with this behavior is essential for its successful treatment.
 ...
PMID:Self-injurious behavior in the developmentally disabled: pharmacologic treatment. 129 22

Eight young adults who were diagnosed with autism were given the opiate antagonist naltrexone to control self-injurious behavior and maladaptive idiosyncratic mannerisms. The drug and placebo were administered in a double-blind crossover design over 17 weeks. Although one subject appeared to have partial decreases in maladaptive behaviors associated with naltrexone use, the drugs, as administered in this study, did not reduce the self-injurious and other maladaptive behaviors of the subjects.
 ...
PMID:Clinical effects of naltrexone on autistic behavior. 149 64

The endogenous opiate release theory of self-injurious behavior (SIB) was investigated through double-blind placebo-controlled administration of naltrexone hydrochloride (Trexan) to a 14-year-old autistic and mentally retarded male for treatment of severe SIB. Results yielded a marked decrease in SIB during two phases of active drug treatment, though SIB did not revert to originally observed placebo levels during a second placebo phase. An increase in social relatedness also was observed during phases of active drug treatment. Opiate theories of self-injury and the possible interrelationship of self-injury with pituitary-adrenal arousal and with social relatedness are discussed.
J Autism Dev Disord 1990 Jun
PMID:A case report of naltrexone treatment of self-injury and social withdrawal in autism. 218 67

Autism is a severe form of childhood psychopathology first described by Leo Kanner in 1943. While over the years there has been substantial controversy about many features of the syndrome, there is today some consensus as to the behavioral characteristics associated with the diagnosis. These include onset of the disorder in the early preschool years, severe and pervasive deficits in social behavior and attachments, deficits in speech and language, insistence for the preservation of sameness, unusual responsiveness to the sensory environment, self-stimulation, self-injurious behavior, isolated skill areas, and inappropriate affect. Another associated feature of many cases of autism is mental retardation. The present article describes these behavioral features as well as the application of the diagnosis and differentiation of autism from other disorders including primary mental retardation, childhood schizophrenia, developmental aphasia, and pervasive developmental disorder.
 ...
PMID:Diagnostic features of autism. 305 87

Reliability and validity data are reported for an instrument designed to identify variables maintaining self-injurious behavior. The Motivation Assessment Scale (MAS) is a 16-item questionnaire that addresses the situational determinants of self-injurious behavior in persons with autism and other developmental disorders. The reliability study indicated that teachers of 50 developmentally disabled persons could agree on the variables presumably maintaining their student's self-injury (interrater reliability), and that they would be in agreement again 30 days later (test-retest reliability). The validity study indicated that teacher's ratings on the MAS of 8 subjects' self-injury predicted how their students would behave in analogue situations. Specifically, the MAS predicted the subjects' self-injurious behavior in situations with decreased adult attention, with increased academic demands, with restricted access to tangibles, and in unstructured settings. The MAS is presented as an alternative or adjunct to more formal functional analyses in efforts to identify the variables controlling self-injurious behavior.
J Autism Dev Disord 1988 Mar
PMID:Identifying the variables maintaining self-injurious behavior. 337 62

This study examined (a) how parents of autistic children, parents of other handicapped children, and parents of nonhandicapped children rate, as a whole, acceptability of time-out, differential reinforcement, overcorrection, and shock as treatments for self-injurious behavior, and (b) whether these parents show differences, as groups, in ratings of these treatments. On the Treatment Evaluation Inventory, all groups consistently rated differential reinforcement, time-out, and overcorrection as acceptable and shock as unacceptable. Differential reinforcement was consistently rated as the most acceptable, but the groups differed in ratings of acceptability of other treatments. On the Semantic Differential, ratings of differential reinforcement, overcorrection, and time-out did not differ. However, shock was consistently rated as the most potent and active of treatments as well as the most unacceptable. The implications of these findings for treatment of autistic and other handicapped children are discussed.
J Autism Dev Disord 1985 Sep
PMID:Parental ratings of treatments of self-injurious behavior. 403 Jun 63

The paper is a theoretical analysis of the evolution of the concepts related primarily to the definition and to the antecedents of self-injurious behavior (SIB). It was found that the definition of SIB as currently used contains surplus meanings unrelated to its scientific utility. At present, a restricted definition of SIB is not warranted because its basic parameters have not been studied adequately. Analysis of SIB taxonomies suggests two subclasses of SIB: social and nonsocial. Epidemiological studies of SIB suggest chronic and acute subsamples that differ in organicity, chronicity, and length of institutionalization. Ecological analysis suggests that a variety of antecedent conditions affect rates and topographies of SIB, e.g., ambient environmental conditions, background settings, situational demands, self-restraint, and type of daily routine activity. Implications were drawn for the organization of therapeutic environments, the study of covariation among collateral topographies, the dynamics of SIB responding, and sequential dependencies among SIB and related topographies.
J Autism Dev Disord 1980 Dec
PMID:The definition, taxonomy, epidemiology, and ecology of self-injurious behavior. 698 54

The effects of haloperidol and a mild punishment on the severe self-injurious behavior and several collateral behaviors of a 17-year-old profoundly retarded male were assessed. A 12-month analysis using a withdrawal design suggested that neither the medication nor the behavioral intervention alone was effective in significantly reducing the frequency of self-injurious behavior. When combined, however, these interventions produced dramatic reductions in the subject's self-injurious behavior. The haloperidol may have acted as a "setting event" for the successful use of the punishment. Suppression of this behavior was maintained at 6 months and 1 year following the end of the analysis. The collateral behaviors were differentially affected by the behavioral and pharmacological interventions. Time spent in bed and the appearance of drooling increased with the introduction of the haloperidol, while percent correct on a fine-motor task increased only when the interventions were applied simultaneously. The results point out the importance of a careful behavioral analysis for both pharmacological and behavioral interventions and their possible combined actions.
J Autism Dev Disord 1982 Sep
PMID:A behavioral/pharmacological intervention for the treatment of severe self-injurious behavior. 715 99

At present, although autism has become accepted as a pervasive developmental disorder, renewed attention is being turned upon the relationship between autism and childhood schizophrenia in recent years. Likewise, the relationship among Heller's syndrome, autism, and childhood schizophrenia has also become a focus of clinical interest. The author presents a case in which discrimination among autism, Heller's syndrome, and childhood schizophrenia is difficult, supplementing discussion from the nosological standpoint. The subject is a male, who was 7 years old at first presentation. Early signs of disorder other than a delay in verbal development were not recognized. At around age 3, a tendency to become isolated at nursery school, and a rambling speech without cohesion was noted at home. Also around this time, the subject was seen to take an obsessive interest in written characters and maps. However, a drastic increase in the severity of symptoms occurred at about 1 week after entering 1st grade with the sudden appearance of hyperactive tendency, accompanied by anxiety at night and loss of control over both urinary and bowel functions. This was followed by the appearance of severe self-injurious behavior, for which the subject came under the care of the author. Subsequently, the author has been involved with the subject therapeutically for about 10 years. In that interval, although a tendency of improvement has been noted in his condition, no substantial change has been recognized in terms of the fundamental disease picture.
 ...
PMID:A case in which diagnosis between autism, Heller's syndrome and childhood schizophrenia is difficult. 789 25


1 2 3 4 5 6 7 8 9 10 Next >>