Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the past, studies have been conducted to determine dental and dental hygiene students' attitudes toward the disabled following their clinical experience. The purpose of this study was to identify how dental hygiene students' attitudes toward treating clients with disabilities changed between the start and the end of their didactic and clinical rotation. Earlier research had examined dental hygiene students' attitudes toward individuals with disabilities following either a limited didactic and clinical course addressing disabilities or at the completion of their dental hygiene education. Few investigations had examined students' attitudes prior to and at the completion of a long-term course on clients with disabilities. The aim of this investigation was to determine if a one-year clinical and didactic course addressing various disabilities would result in a significant change in the students' attitudes and comfort level when treating clients with disabilities. The survey researched the attitudes of 18 senior dental hygiene students in the special care clinic at Baylor College of Dentistry, Texas. The students received a pre- and post-modified survey of the "Dental Students' Attitudes Toward the Handicapped Scale" and were asked to rank their responses from strongly agree (5) to strongly disagree (1). The following areas were assessed: Group 1 (Positive Perceptions of Educational Training); Group 2 (Negative Attitude Toward Treating Persons with Disabilities); Group 3 (Providing Dental Services); Group 4 (Negative Perceptions of Educational Training); and Group 5 (Comfort Level when Treating Persons with Disabilities). There was a significant improvement in the students' attitudes in Groups 1, 2 and 4 with p-values for the questions in these groups ranging between p < 0.001 to p < 0.05. In Group 3, only two out of the five questions yielded a significant change in attitude, p < 0.001 to p < 0.01. Following the rotation, when asked about their comfort level in treating clients with disabilities (Group 5), the students reported being comfortable treating persons with autism p < 0.01, cerebral palsy p < 0.05, quadriplegia and paraplegia p < 0.05.
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PMID:Dental hygiene students' attitudes toward treating individuals with disabilities. 961 52

GluD2 receptor belongs to the orphan delta family of glutamate receptor ion channels. These receptors play key roles in synaptogenesis and synaptic plasticity and are associated with multiple neuronal disorders like schizophrenia, autism spectrum disorder, cerebellar ataxia, intellectual disability, paraplegia, retinal dystrophy, etc. Despite the importance of these receptors in CNS, insights into full-length GluD2 receptor structure is missing till-date. Here we report cryo-electron microscopy structure of the rat GluD2 receptor in the presence of calcium ions and the ligand 7-chlorokynurenic acid, elucidating its 3D architecture. The structure reveals a non-swapped architecture at the extracellular amino-terminal (ATD), and ligand-binding domain (LBD) interface similar to that observed in GluD1; however, the organization and arrangement of the ATD and LBD domains in GluD2 are unique. While our results demonstrate that non-swapped architecture is conserved in the delta receptor family, they also highlight the differences that exist between the two member receptors; GluD1 and GluD2.
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PMID:The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. 3251 55