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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fragile X chromosome is an important factor in inherited mental retardation in males. It has also been reported that infantile autism is associated with fragile X. Recently, an article reported an examination of a small sample of autistic children in whom the fragile X chromosome was not found. Its authors concluded that if an association between fragile X and autism exists, it is infrequent. In the present study of 144 autistic male subjects, 18 were found to have the fragile X chromosome, supporting other (epidemiological) findings that the association between fragile X and autism occurs relatively frequently.
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PMID:Autism and the fragile X syndrome. 345 2

Fragile X syndrome is a recently identified form of mental retardation that is associated with a chromosomal abnormality and inherited in an X-linked manner. Previous studies have suggested that distinctive speech and language characteristics are associated with the syndrome. Twelve adult male residents of an institution for the retarded (aged 23 to 51 years) were compared on a series of speech and language measures to 12 adult males with nonspecific forms of MR who were residents of the same institution and were matched on age and IQ. A second contrast group consisted of similarly matched autistic men. Results revealed that there were no significant differences among the groups' performance, with the exception of increased rates of echolalia in the autistic group. A nonsignificant trend toward poorer performance on expressive measures on the part of the fragile X group was noted. The implications of these findings for further research on the syndrome are discussed.
J Autism Dev Disord 1987 Dec
PMID:A comparison of language characteristics of mentally retarded adults with fragile X syndrome and those with nonspecific mental retardation and autism. 347 23

There are reports of sex chromosomal abnormalities including XXY, XYY, and fragile X karyotypes in autistic individuals, but structural autosomal defects have rarely been reported. This paper presents four patients with autism, mental retardation, minor dysmorphic features, and structural autosomal defects. These patients shared autistic features including fascination with inanimate objects, catastrophic reactions to changes in their environment or their daily routine, echolalia, and poor relatedness; IQ scores indicate mild to severe retardation. Their autosomal abnormalities included inversion/duplications of 3p and 16q, 5p+, and 17p-. Parental chromosomes were all normal. Chromosomal analysis should be performed on mentally retarded, autistic individuals, especially those with minor physical anomalies and no specific etiology for their retardation.
J Autism Dev Disord 1986 Dec
PMID:Autism, mental retardation, and chromosomal abnormalities. 354 57

A brief account of the main diagnostic distinctions between autism and mental retardation is provided, which serves as the basis for reviewing available evidence on possible commonalities and differences in the developmental backgrounds of these two groups of children. Systematic comparisons in the histories of the two groups have rarely been undertaken, yet they are crucial for understanding the agents and processes uniquely associated with the genesis of each condition. Specific suggestions are made on some fruitful avenues for such comparative research undertakings.
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PMID:Early developmental backgrounds of autistic and mentally retarded children. Future research directions. 354 89

Delay in language development may be associated with an underlying anatomical, neurosensory, or psychological disorder such as: deafness, cerebral palsy, cleft palate, autism, or mental retardation. A condition called specific developmental language delay may occur in children devoid of any other identifiable disorder or developmental delay. Language delay associated with early onset, severe-to-profound hearing impairment has been well documented. Controversial studies have also appeared in the communicative disorders' literature suggesting that fluctuating conductive hearing loss in early childhood can significantly affect the development of language and related academic skills. Some authors have claimed that these deleterious effects can be irreversible. This study focuses on 3 groups of preschool children, in whom hearing acuity has been documented: One group with recurrent otitis and language delay; a second group with an equally well documented otitis history but without language delay; and a third group with documented language delay in the absence of any known predisposing conditions, including early-onset, recurrent otitis media. Prenatal, birth and developmental histories of the children in each group were compared in detail to identify any factors which may enhance or ameliorate the effects of fluctuating conductive hearing loss on language development. In a population of 1864 children (ages 9-59 months) referred for otolaryngologic and/or communicative evaluation, 480 otherwise normal children (67.6% males; 32.4% females) were found to have a history of early-onset, recurrent otitis media and/or delayed speech and language development on the basis of an extensive evaluation battery. This population was further subdivided into 3 groups (I = otitis-positive/normal language; II = otitis-positive/language delay; and III = otitis-free/language delay). Among the 329 children with positive histories for early otitis media (Groups I & II), a significantly higher percentage of those demonstrating language delay were from homes in the lower socio-economic category. Race and sex showed no significant relationship to language delay among the otitis-positive groups, although males were twice as numerous as females in the over-all study population. Articulation errors on speech measures and borderline delays in other developmental milestones (standing, walking, and toilet training) were also significantly greater in the language-delayed group when compared with otitis-positive children whose language was age-appropriate.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Medical profile of the language-delayed child: otitis-prone versus otitis-free. 358 81

Talking was increased in an 11-year-old girl who recently had stopped talking to anyone in any setting, despite the absence of biological factors, mental retardation, and autism. Productive labeling (correctly naming picture cards) and functional language (talking about picture cards in the absence of such pictures) were interspersed with a series of treatment packages (including verbal instructions, imitation, tokens, and praise). Interventions for productive labeling were programmed in a changing-criterion design. Interventions for functional language were programmed in an ABC design. Higher levels of productive labeling and functional language were noted with the introduction of the particular package, in comparison to baseline. The results also showed the generalization of the procedures to the shaping of functional language in the absence of picture cards.
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PMID:Labeling and functional language in a case of psychological mutism. 366 55

A diagnostic questionnaire was used to study the abnormalities that parents first noticed, the ages at which parents first noticed these early symptoms, and the main problems the parents complained about in the first consultation. In this study, parents of 141 autistic children below the age of 12 were employed. Approximately 71% of the parents noticed abnormalities in their autistic children by the age of 2 1/2 years. Parents of older autistic children tended more often to report symptoms of mental retardation, ritualistic behavior, and self-injury. This study showed that the Japanese peak of abnormal social behavior, including autistic symptoms as reported by parents, was from the ages of 3 years to approximately 9 years, compared with the U.S. and European peak of 3 to 6 years.
J Autism Dev Disord 1987 Dec
PMID:Parental perception of behavioral symptoms in Japanese autistic children. 368 Jan 55

Infantile autism is a developmental disability characterized by onset of disturbances in social and language development before the age of 30 months. It must be distinguished from several disorders, including mental retardation and schizophrenia. Most evidence supports an organic basis for the syndrome. Treatment consists of training in language and communication skills, behavioral modification and, occasionally, chemotherapy. Supportive counseling and education for parents are vital to treatment. The prognosis for achieving a life of complete independence is poor.
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PMID:Infantile autism. 371 67

The Rimland E2 questionnaire was applied to three groups of children for whom clinical diagnoses of Infantile Autism, Autism with Associated Symptoms, and Mental Retardation had been made, as well as to normal controls. The results confirm that the Rimland scale is accurate in differentiating autistic from nonautistic children. But the scale does not appear to permit clear differentiation of infantile autism from autism with associated symptoms, and the more typical autistic children (diagnosed as Kanner's EIA) did not all yield high scores. Several possible explanations for this fact are put forward.
J Autism Dev Disord 1986 Jun
PMID:Comparison of clinical diagnoses and Rimland E2 scores in severely disturbed children. 372 19

The pervasive developmental disorders (PDD), as exemplified by infantile autism, are a group of severe childhood neuropsychiatric disorders of early onset in which multiple areas of social, communicative, and cognitive development are disturbed. Although these disorders often are associated with some degree of mental retardation and various medical and neurological abnormalities, they are distinctive in their course and outcome, and in the patterns of development deficit. These conditions, which are expressed as the final behavioral syndrome, probably have many different causes. Whereas organic factors clearly are implicated, no precise etiological mechanisms have been established. Management of these disorders includes appropriate educational and behavioral intervention. Efforts are needed to define these disorders more precisely, and to identify relevant subgroups, to further studies of pathophysiology.
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PMID:Current concepts: infantile autism and the pervasive developmental disorders. 377 7


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