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Query: UMLS:C0004352 (autism)
 32,579 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors review the clinical features and behavioral characteristics of autism; differential diagnosis of the syndrome; clinical, neurophysiological, and biochemical research; and its medical management and treatment. They conclude that autism is a behaviorally defined, specific syndrome that is manifested at birth or shortly thereafter. Its symptoms are expressive of an underlying neuropathophysiological process that affects developmental rate; modulation of perception; language, cognitive, and intellectual development; and the ability to relate. The long-term prognosis is guarded; almost all patients manifest severe symptomatology throughout their lives. Further basic research into the neuropathophysiological process underlying the syndrome is necessary in order to reach the ultimate goal of developing etiologically specific treatment programs.
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PMID:The syndrome of autism: a critical review. 5 60

Serum creatine phosphokinase (CPK) levels were studied in individuals: 40 psychotic children suffering from childhood autism, atypical personality development, and childhood schizophrenia; five children with childhood aphasia; 22 children with severe personality disorders; 29 normal children and normal siblings of psychotic children; and 14 normal parents of psychotic children. Creatine phosphokinase levels from the entire population of adults and children were normally disturbed, and the mean CPK levels for the eight diagnostic groups were within normal limits. Those 22 children with personality disorders had significantly higher CPK levels than the other diagnostic groups. This relatively higher level of CPK may be related to vulnerability to later development of schizophrenic spectrum disorders. There was no apparent relationship between CPK levels and motor activity, nor was there any change in the level of CPK during a trial of psychoactive medication. Creatine phosphokinase levels remained relatively stable on test-retest determination.
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PMID:Creatine phosphokinase levels in children with severe developmental disturbances. 5 82

The authors discusses some unclear and insufficiently studied problems related to early infantile autism, regress of development and underdevelopment of schizophrenic children. The basis of early infantile autism is most likely a peculiar disturbance of development due to constitutional, organic and psychogenic factors. In most of the cases this syndrome is connected with the schizophrenic process. The majority of psychiatrists in the Soviet Union consider lowering to a more early level of development as a regress of development in child schizophrenia symptoms. The clinical picture of retarded development in childhood schizophrenia depends upon the age of the onset of the disease and the degree of progressiveness of the process. Depending upon these criteria it is possible to distinguish retarded development, resembling oligophrenia and phenomena of psychophysical infantilism.
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PMID:[Several developmental disorders in children with schizophrenia]. 6 1

The purpose of this study was to evaluate the use of operant conditioning techniques to toilet train children in an autism ward of a hospital for developmentally disturbed children. Five profoundly retarded males with clear clinical manifestations of autism were selected as subjects. Records of the urination behavior of these subjects were kept during a baseline period and throughout the application of procedures. Appropriate urination behavior was immediately followed by positive reinforcers, such as candy, verbal praise, and physical affection. Inappropriate urination behavior was immediately followed by negative reinforces, verbal as well as physical. The results of this study show that operant conditioning techniques can be used to change the urination behavior of profoundly retarded autistic children even where other methods have failed. Factors requiring further investigation for their possible impact on the effectiveness of these procedures in toilet training autistic children are also discussed.
J Autism Child Schizophr 1977 Jun
PMID:Training autistic children to urinate in the toilet through operant conditioning techniques. 6 52

A sample of 74 young autistic children was selected and defined by direct observation of specific behaviors and clinical assessment of the presence or absence of associated pathological conditions. Retrospective developmental data on these children and 38 age-matched normal children were gathered by means of a written inventory completed by the parents when the children were relatively young (mean age less than 4 years). The autistic children were reported to have had significant delays in the development of motor abilities, speech, communication, comprehension, and, to a lesser extent, perception during their 1st and 2nd years.
J Autism Child Schizophr 1977 Sep
PMID:The early development of autistic children. 7 Dec 92

The concept of developmental disabilities as a group of problems with origins in the stages of human development has been broadened by recent legislation to include mental retardation, cerebral palsy, epilepsy, autism, dyslexia, and other neurological impairments. The debate continues on whether or not specific disability categories should be named, but the functional aspects of the problems seem to be generally accepted. Potential implications of this legislation for occupational therapy are discussed in this paper. Numerous programs supported by a variety of governmental units and private agencies will need qualified professionals. This paper concludes with a brief list of six developmental disability programs of the University of Michigan University Affiliated Facility and an outline of three models of field placement in developmental disabilities for occupational therapy students.
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PMID:Developmental disabilities. 7 85

Previous research suggests that verbal deficits among psychotic children may be paralleled by deficits in nonverbal pantomime. However, certain questions such as the level of pantomime exhibited by psychotic children, its susceptibility to modification, and its relation to other symbolic functions have not been systematically examined. To investigate these issues, 24 psychotic children were required to represent absent objects (e.g., toothbrush) via pantomime after receiving verbal instructions or instructions accompanied by a model demonstrating the pantomime. Also, measures of receptive and expressive speech, human figure drawings, and pretend play were obtained. The findings indicated very few complete failures in pantomime; higher pantomime performance when a model was provided although even in this condition most responses consisted of low-level substitutions of a body part in place of the absent object; and significant relationships between pantomime and measures of receptive vocabulary, echolalia, drawing, and play. The relationship of the findings to symbolic functioning in normal children and their relevance to understanding symbolic deficits in psychotic children are discussed.
J Autism Child Schizophr 1978 Jun
PMID:Pantomimic representation in psychotic children. 7 26


J Autism Dev Disord 1979 Mar
PMID:Journal of Autism and Childhood Schizophrenia. Change of journal scope and title. 8 33

Three biotelemetric examinations and a whole night sleep recording were carried out in an 8-year-old child whose behaviour alternated between excitation and autism with stereotypes. The EEG showed 5 c/sec temporo-parietal sharp wave discharges lasting from 1 sec to 20 min. These discharges were at times unilateral and predominantly right sided, at other times bilateral, without any clinical sign of epilepsy. The chronological distribution of right, left and bilateral discharges during the successive 1 min epochs was computed and related to corresponding 'behavioural states' of the child. The paroxysmal discharges predominated when the child was awake but not involved in any relational activity; during sleep, they mostly appeared during light NREM sleep (stage I) and paradoxical sleep. The significance of these paroxysmal discharges is discussed in relation to stereotyped behaviour, vigilance and early disorganization of biological rhythms.
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PMID:Long duration EEG studies in the case of a psychotic child. 8 47

This study (1) examined whether a self-monitoring procedure taught in a laboratory setting would increase independent on-task behavior there and would generalize without further teaching to a classroom setting, and (2) analyzed the durability of the training effects over the course of 5 months for one subject and 10 months for two other subjects. Two multiple-baseline designs, one across three normal and the other across three deviant children, showed that self-monitoring of academic task-completions facilitated on-task responding for all subjects in the generalization (classroom) setting. A subsequent reversal design showed that these effects were durable, in two of the three subjects still available, at least as much as 1 year after commencement of training. This latter design also suggested that one subject who was not maintained by self-monitoring could be supported in on-task behavior by a peer who was maintained by self-monitoring.
J Autism Dev Disord 1979 Dec
PMID:Facilitating generalization of on-task behavior through self-monitoring of academic tasks. 9 6


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