Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cardiovascular eicosanoids are of significance in relation to regulation of hemostasis and flow under healthy and pathological conditions. In healthy subjects, TxA2 and PGI2 participate in the maintenance of vascular integrity in relation to vascular injury. In this respect, vascular eicosanoids can be regarded as constituents of a balancing system which favours platelet deaggregation in intact vessels but platelet aggregation in a injured vessel. Degenerative arterial disease, like e.g. atherosclerosis, disturbs the balance and favours platelet activation and adhesion to vascular surfaces. This may promote the development of platelets thrombi in the absence of vascular injury and lead to thrombosis.
Acta Physiol Pol
PMID:Role of eicosanoids in the cardiovascular system. 307 7

The method of vascular casts was used for investigation of the cerebral vessels in subjects with atherosclerosis. The studied material comprised 35 brains taken from patients aged 70-85 years who died after strokes and 5 brains of patients aged 21-30 years who died after traffic accidents as a control group. It was found that small vessels in the atherosclerotic brains were tortuous and had numerous narrowings, they appeared elongated, and their course differed from that in young subjects. The casting method provided oval-shaped impressions of endothelial cell nuclei which could not have been visualized so clearly with the previously used histological methods.
Neurol Neurochir Pol
PMID:[Postmortem study of the cerebral vascular system by the method of vascular casts in patients with ischemic cerebral infarction]. 326 34

In a group of 1621 patients with vascular brain lesions (849 males, 772 females) the authors found seizures in 108 cases (56 males, 52 females): in 26 cases of subarachnoid haemorrhage (aneurysms), 6 cerebral haemorrhages, 24 cerebral arterial thromboses, 18 atherosclerosis of brain vessels, 13 cases of embolia, 4 cases of transient cerebral ischaemia, 4 cases of vertebrobasilar insufficiency, 4 cases of cerebrocardiac syndromes, 2 cases of cerebral form of the Winiwarter-Buerger disease and 1 cases each of cerebellar haemorrhage and aortic arch syndrome. In 8 cases family history of epilepsy was elicited. The authors suggest administration of anticonvulsants in justified cases.
Neurol Neurochir Pol
PMID:[Epileptic seizures in patients with vascular brain lesions]. 358 13

The effect of colchicine on the course of experimental atherosclerosis was investigated in rabbits receiving for 3 months a high-lipid diet (HLD) in addition to the basal diet. Colchicine was given in a dose of 0.2 mg/kg ip twice a week. An evident antiatherosclerotic action of colchicine was demonstrated both by macroscopic and microscopic investigation of the aorta. The level of blood total lipids was significantly depressed, and the level of triglycerides was back to normal. The content of total lipids in liver homogenates was similar to that in the controls. A significant decline in the fibrinogen concentration in the blood of rabbits receiving colchicine was also found.
Pol J Pharmacol Pharm
PMID:The effect of colchicine on the development of experimental atherosclerosis in rabbits. 377 28

The mechanism of antiplatelet potency of prostanoids and pharmacological methods that regulate their endogenous release are discussed. In addition the role of antiaggregatory prostanoids in atherosclerosis and some clinical trials with prostanoids are reviewed.
Acta Physiol Pol
PMID:Anti-aggregatory prostanoids. Part II. 391 32

Sulocton effect was evaluated in 33 patients with symptoms of brain ischaemia during atherosclerosis. Thirty patients received the drug orally for 2 months in doses of 100 mg thrice daily. Three patients discontinued the treatment earlier (two of them discontinued it because of side effects). After two months of treatment a significant improvement was observed in such disturbances important for wellbeing and social contacts as: anxiety and fear, mood depression, disequilibrium of emotion, motivation and initiative. In many patients headaches, dizziness and gait disturbances disappeared or diminished. Sulocton was useful in the treatment of patients with cerebral atherosclerosis.
Neurol Neurochir Pol
PMID:[Evaluation of sulocton action in patients with atherosclerotic brain ischemia]. 629 59

A case of segmental spinal necrosis is described involving the area of supply of the sulcocommissural artery. The location of the necrosis and recurrent course of the disease suggest a vasogenic mechanism of the disease in the patient with atherosclerosis and hypertension.
Neurol Neurochir Pol
PMID:[A case of segmental spinal cord necrosis in the area supplied by the sulcocommissural artery]. 672 8

The report is based on 315 patients with subacute and chronic cerebral circulatory disturbances caused mostly by atherosclerosis aged 30 to 82 years, treated for 1-6 months. In 90 cases Piracetam (Nootropil) was given, 107 received Piritinol (Encephabol, Enerbol), 77 Piriditol, 41 Centrophenoxin. The patients were allocated randomly to these groups. In the treated patients improvement was achieved in a considerable proportion of cases (44-82%) treated with different drugs. This improvement manifested itself as regression or decreased intensity of neurotic complaints, labyrinthine-cerebellar signs, pyramidal signs, anxiety and fears, improvement of recent memory, attention, psychomotor activity. The best results were obtained with Nootropil, moderately good with Centrophenoxin, Encephabol, and poor with Piriditol. Drug tolerance was best with Encephabol, while that of other drugs was slightly worse. The only disquieting symptoms was activation of epileptic seizures in several patients treated with Nootropil or Centrophenoxin. The best way of administration was giving the drugs in two doses in the morning hours and at noon. The authors regard as useful the treatment of patients with subacute and chronic cerebral circulatory failure with psychoenergizing drugs.
Neurol Neurochir Pol
PMID:[Comparative evaluation of psychoactive drugs used in patients with subacute and chronic cerebrovascular disorders]. 679 48

The authors analysed the effectiveness of Lipanthyl treatment in 38 patients after stroke undergoing rehabilitation treatment. The effects of the drug were evaluated on the general condition, neurological and psychic status, progression of motor rehabilitation, and on lipid metabolism parameters. A statistically significant improvement was obtained in the subjective and psychic condition, and the results of motor rehabilitation were slightly better than in the compared groups of patients. Lipid metabolism was normalized only in part (cholesterol, chylomicrons). In the conclusions the authors state that it is useful to give this drug to patients with cerebral atherosclerosis only if disturbances of lipid metabolism coexist with this disease and are refractory to dietetic treatment.
Neurol Neurochir Pol
PMID:[Changes in blood lipids after stroke in patients treated with lipanthyl]. 687

In the paper the author summarized the results of investigations of vasoactive preparations of various action in patients with ischaemic cerebral circulatory disturbances due to hypertension and atherosclerosis. After clinico-rheographie correlations it was concluded that each vasoactive agent should be used taking into account the pathogenetic mechanisms of cerebral circulatory disturbances. Better results were obtained treating patients with preparations with antihypoxic properties and those influencing cerebral metabolism.
Neurol Neurochir Pol
PMID:[Current treatment of cerebrovascular disorder with vasoactive drugs]. 689 79


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