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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Computerized tomography of the head was done in 5021 patients aged 21 to 81 years from various neurological, neurosurgical and neurotraumatological indications. Brain atrophy as an only finding (primary) was noted in 11.5%- and in 5.4% of cases it was associated with other changes. The neurological-radiological correlations were established in 200 cases of primary strophy. History data included: headaches in 54.5%, dizziness in 15.0%, epilepsy in 24.5%. Objective examination showed: slight hemiparesis in 37.5%, spastic-atactic gait disturbances in 31.5%, isolated damage to the corticospinal tracts with signs limited to one side of the body was more frequent in cortical atrophy, and these signs associated with ataxia were more frequent in subcortional atrophy. The authors explain this as a loss of cortical cells or damage to the paraventricularly coursing nerve fibres. A probable aetiology of "primary" atrophy was established in 405% of cases (hypertension, atherosclerosis, minor craniocerebral trauma). No signs or neurological syndromes were observed which could be regarded as more or less characteristic of brain atrophy.
Neurol Neurochir Pol
PMID:[Brain atrophy: radiological-neurological correlations]. 213 53

A number of current issues regarding methods of primary and periodical medical examinations were discussed in view of application of research results in practical activities of the occupational health service. The review of tests employed on detection of deficiency or peculiarity of biochemical susceptibility to given chemical factors revealed objective causes limiting and delaying, to a certain extent, of practical application of scientific progress in health surveillance. Tests facilitating detection of susceptibility to emphysemagenic factors, genetic markers of atherosclerosis, neoplasm (especially neoplasm of the urinary bladder and lung cancer) were discussed. According to the opinions presented, further advancement of research, as well as application of new methods should, during a relatively short time, dispel existing doubts and accomplish standardization of methods. The usefulness of psychological tests, now being introduced to health surveillance, was also discussed. It was found that tests may enrich considerably certification of physical fitness for those jobs with high stress levels and requiring a high level of reliability. They are extremely useful in individual assessment of work load, and they allow the detection of early disorders in the central and peripheral nervous system, preceding evident pathology produced by working environment factors. The most common obstacles in the wide application of the discussed methods include: inadequate post-graduate education of psychologists; the rare combination of two specialisations (psychology of labour and clinical psychology); and a shortage of test methods which have been verified in the conditions of a given country. This work also raises questions about the health effects of exposure to electromagnetic radiation, complex exposure to toxic substances, health condition and periodical examinations in workers of advanced age.
Pol J Occup Med 1990
PMID:The strategy of targetted health surveillance. II. Genetically determined susceptibility to chemical substances and other issues related to health surveillance. 213 19

In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, as well as the density of nuclei of myocytes. The values of all histometric parameters correlated well with the LV weight up to 350 g. In heavier hearts these parameters were approximately at the same magnitude. The number of myocytes was significantly higher in hearts with LV weight above 250 g than in hearts below 250 g: 5.53 x 10(9) vs 4.31 x 10(9), p less than 0.001. The influence of coronary artery diameters, degree of atherosclerosis, weight and percent of fibrous tissue and age on LV weight were evaluated as well. Only coronary artery diameters significantly influenced on LV weight. On the basis of linear discriminant function, three classes of hearts were separated: 1) LV weight 250 g - absence of hyperplasia, only hypertrophy 2) LV weight 251-350 g - hypertrophy + signs of hyperplasia 3) LV weight 350 g - marked signs of hyperplasia Among 18 patients with the LV weight above 350 g (all patients with congestive heart failure), 11 suffered from valvular disease, 3 were postinfarction patients, 2 suffered from primary hypertension and 2 from primary congestive cardiomyopathy. It indicates that, irrespective to the etiologic factor, hyperplasia is a simple result of the cardiac muscle mass increase.
Kardiol Pol 1990
PMID:[Myocardial structure in various forms of hypertrophy. II. Myocyte hypertrophy or hyperplasia? Results of the study]. 215 Jun 80

Between 1984 and 1987 1000 consecutive patients with stated or suspected ischemic heart disease underwent selective coronarography and left ventriculography. Patient's age ranged from 23 to 70 years (mean - 47 yrs). Atherosclerotic lesions in three main coronary arteries: left anterior descending, circumflex and right coronary artery were assessed. Stenosis exceeding 50% of a vessel lumen was considered as a significant one. Changes were evaluated in the whole group of patients and in two subgroups in relation to patients age (younger and older than 40 years). Besides assessment of atherosclerotic changes in coronary arteries a presence of IHD risk factors, family occurrence, disease progress and methods of further therapy were analyzed. 60.9% of patients had a documented history of myocardial infarction in the post. Unchanged coronary arteries were found in 77 patients (7.7%), one isolated coronary artery stenosis in 145, single coronary artery stenosis with nonsignificant atherosclerotic lesions in other arteries in 328. Two significantly narrowed arteries were found in 285 patients and 101 subjects had significant changes in three coronary arteries. Analysis of further therapy revealed following results: 520 patients underwent PTCA or CABG (270 - PTCA and 250 - CABG), 439 were conservatively treated and only 41 did not need further cardiological care. Comparing atherosclerotic changes in patients younger and older than 40 years, a statistically significant correlation between patient's age and a number of coronary artery stenosis was stated. Diffuse coronary atherosclerosis more frequently occurred in patients more than 40 years. In youngers changes mainly concern a single coronary artery.(ABSTRACT TRUNCATED AT 250 WORDS)
Kardiol Pol 1990 Feb
PMID:[Coronarography in 1000 consecutive patients--clinical aspects]. 227 89

A 7-month experiment was carried out on guinea pigs to elucidate the effect of height-cholesterol diet containing various fats on the levels of ascorbic acid and to tocopherol in the organism. In the guinea pigs with experimentally induced atherosclerosis the retention of ascorbic acid and tocopherol was found to be greater than that in the control animals.
Acta Physiol Pol
PMID:Ascorbic acid and tocopherol levels in the organs and serum of guinea pigs with experimentally induced atherosclerosis. 248 53

Radioimmunoassay of serum thyroid hormones (T3 and T4), testosterone, estradiol, insulin and cortisol of rabbits fed on a high-fat diet (coconut oil, cholesterol, cholic acid) for three months and developing experimental atherosclerosis (confirmed by biochemical tests and morphological changes in the aorta) have revealed an increase in the content of estradiol and insulin, and a decline in the level of thyroid hormones and testosterone.
Pol J Pharmacol Pharm
PMID:Endocrine functions in atherosclerotic rabbits. 259 77

Medical histories of 310 patients of a pulmonary department were analysed. All were older than 60 years. They made up 41.6% of treated patients during this time. More than two diseases were present in 79.3%. Most often the following disorders were found: chronic obstructive lung disease, pneumonias, pleuritis, circulatory insufficiency, atherosclerosis, disrhythmias, acute coronary diseases. In 68.2% good results of therapy were observed clinical improvement and complete resolution of changes were however seen in only 5.2%. Therapeutical side effects were seen in 29.7%. During hospitalization 10.9% of the patients died. The most common cause of death was atherosclerosis and malignancy. Mean hospital stay was 36.5 days and was 6 days longer in comparison with younger patients.
Pneumonol Pol 1989 Mar
PMID:[Elderly patients at the Pulmonary Disease Department]. 262 28

Current evidence indicates that the non-selective beta-blocker propranolol reduces the severity of experimental atherosclerosis in animal model. We studied the effect of propranolol on cholesterol ester synthesis and storage in mouse peritoneal macrophages in vitro. Propranolol in concentrations found in the plasma of patients treated with it (150 ng/ml) decreased by 20-30% beta-VLDL-stimulated synthesis of cholesterol esters with (14C)-oleate. A similar effect was observed also on this synthesis stimulated by acetyl-LDL. In a similar degree the accumulation of cholesteryl esters in the cells was decreased during the 48-hour incubation with lipoproteins in the presence of propranolol. No effect of the drug was observed on the uptake and degradation of beta-VLDL or acetyl-LDL. These observations suggest that propranolol may inhibit cholesteryl ester accumulation in macrophages at the point subsequent to lipoprotein uptake. This may have an impact on the treatment or prevention of atherosclerosis.
Mater Med Pol
PMID:Propranolol decreases cholesteryl ester accumulation in mouse peritoneal macrophage in vitro. 263 14

Two stage low-calorie diet (1000 kcal/day for 3 weeks in the hospital and assumed 1000 kcal/day for 4 weeks at home) was applied in a group of 40 children aged 7 to 17 years with obesity 25-99%. The beneficial effect of the diet in the form of a decrease of cholesterol level has been found. Treatment with low-calorie diet of children with simple obesity has an essential significance in the prevention of atherosclerosis appearing at the later stage of life.
Pediatr Pol
PMID:[Lipid metabolism in obese school-age children. II. The changes occurring after the treatment with low-calorie diet]. 264 13

Occurrence of atherosclerosis risk factors was analyzed in 16 women aged 26-45 with myocardial infarction. The control group consisted of women of the same age and profession. Stated risk factors were in order: hypertension, diabetes mellitus, positive family history, fat metabolism disturbances, stress and cigarette smoking. The most hazardous association was fat metabolism disturbances connected with hypertension, positive family history or hypertension or excess sensibility to stress were also frequently observed. Authors stated three, four, five and even six risk factors together in 64.3% of women after myocardial infarction.
Kardiol Pol 1989
PMID:[Occurrence of risk factors for atherosclerosis in young women with myocardial infarction]. 281 Oct 20


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